Tag Archives: DNA

Parasitic DNA proliferates in aging tissues

By Guest PostJanuary 5, 2014Healthaging tissues, cancerous tissue, cancerous tumors, cell culture, DNA, fruit fly drosophila, hepatocellular carcinoma, jill kreiling, john sedivy, journal aging, lymphoma, marco dececco, normal tissues, parasitic dna, replicative senescence, retrotransposable elements, robert reenan, rtes, stephen helfand

As mice age, cells in tissues such as the liver and skeletal muscle lose control over rogue sequences of DNA called “retrotransposable elements,” according to new research in the journal Aging. The elements, which may undermine health, could proliferate in old mice and were also abundant in cancerous tissue. A low-calorie diet, however, restrained their advance.

PROVIDENCE, R.I. [Brown University] — The genomes of organisms from humans to corn are replete with “parasitic” strands of DNA that, when not suppressed, copy themselves and spread throughout the genome, potentially affecting health. Earlier this year Brown University researchers found that these “retrotransposable elements” (RTE’s) were increasingly able to break free of the genome’s control in cultures of human cells. Now in a new paper in the journal Aging, they show that RTEs were increasingly able to break free and copy themselves in the tissues of mice as the animals aged. In further experiments the biologists showed that this activity was readily apparent in cancerous tumors, but that it also could be reduced by restricting calories. (more…)

SOFS Take to Water

By Guest PostJanuary 5, 2014Science2d honeycomb, aka chemistry, berkeley lab, chemical signals, DNA, double helix, emergence of nanotechnology, force, metal organic frameworks, mofs, molecule, non covalent bonds, saxs, sofs, solubility in water, supramolecular chemistry, supramolecular organic frameworks, van der waals, xin zhao, yi liu, zhan ting li

Researchers at Berkeley Lab’s Molecular Foundry Create First Soluble 2D Supramolecular Organic Frameworks

Supramolecular chemistry, aka chemistry beyond the molecule, in which molecules and molecular complexes are held together by non-covalent bonds, is just beginning to come into its own with the emergence of nanotechnology. Metal-organic frameworks (MOFs) are commanding much of the attention because of their appetite for greenhouse gases, but a new player has joined the field – supramolecular organic frameworks (SOFs). Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have unveiled the first two-dimensional SOFs that self-assemble in solution, an important breakthrough that holds implications for sensing and separation technologies, energy sciences, and, perhaps most importantly, biomimetics. (more…)

IBM Reveals Five Innovations That Will Change Our Lives within Five Years

By Guest PostDecember 17, 2013Education, Science, Technologyattack the cancer, big data analytics, breakthroughs, cancer treatment plans, change our lives, cloud computing, cognitive experience lab, cognitive systems, computing, dario gil, digital guardian, DNA, five innovations, ibm, ibm scientists, incidence of cancer, learning technologies, new era, stolen identity, uganda, unicef, vital information, within five years

IBM Predicts – in Five Years Everything will Learn

ARMONK, N.Y. – 17 Dec 2013: Today IBM unveiled the eighth annual “IBM 5 in 5“ (#ibm5in5) – a list of innovations that have the potential to change the way people work, live and interact during the next five years.

This year’s IBM 5 in 5 explores the idea that everything will learn – driven by a new era of cognitive systems where machines will learn, reason and engage with us in a more natural and personalized way. These innovations are beginning to emerge enabled by cloud computing, big data analytics and learning technologies all coming together, with the appropriate privacy and security considerations, for consumers, citizens, students and patients. (more…)

Staphylococcus aureus bacteria turns immune system against itself

By Guest PostDecember 6, 2013Healthadenosine synthase a, adsa gene, antibiotic resistant strain, bloodstream, dado, deoxyadenosine, destroy, DNA, dominique m missiakas, human function, immune defense mechanism, immune system, kevin jiang, macrophage, mrsa, mutation, nets, neutrophil extracellular traps, nuc, olaf schneewind, protein, s. aureus, staphylococcal nuclease, staphylococcus aureus bacteria, university of chicago, vilasack thammavongsa, white blood cells

Around 20 percent of all humans are persistently colonized with Staphylococcus aureus bacteria, a leading cause of skin infections and one of the major sources of hospital-acquired infections, including the antibiotic-resistant strain MRSA.

University of Chicago scientists have recently discovered one of the keys to the immense success of S. aureus—the ability to hijack a primary human immune defense mechanism and use it to destroy white blood cells. The study was published Nov. 15 in Science. (more…)

Cause of genetic disorder found in “dark matter” of DNA

By Guest PostNovember 18, 2013Healthblood, cause, cell, dark matter, disease, DNA, genetic disorder, glucose, junk dna, mike weedon, pancreatic agenesis, pancreatic beta cells, professor andrew hattersley, ptf1a regulatory region, regulating level, sugar, type 1 diabetes, university of exeter

For the first time, scientists have used new technology which analyses the whole genome to find the cause of a genetic disease in what was previously referred to as “junk DNA”.

Pancreatic agenesis results in babies being born without a pancreas, leaving them with a lifetime of diabetes and problems digesting food.

In a breakthrough for genetic research, teams led by the University of Exeter Medical School and Imperial College London found that the condition is most commonly caused by mutations in a newly identified gene regulatory element in a remote part of the genome, which can now be explored thanks to advances in genetic sequencing. (more…)

Nice genes! What makes you genetically compatible with your partner?

By Guest PostSeptember 8, 2013Scienceankylosing spondylitis, anthony nolan trust, australia, auto immune disease, bbc breakfast, compatibility gene, DNA, eastern europe, Europe, genetic make up, hiv, human genes, India, penguin, problems in pregnancy, professor daniel davis, second world war, swiss zoologist, uk charity, wife katie

Professor Daniel Davis and his wife Katie’s experience is documented in The Compatibility Gene, published by Penguin, which discusses how our crucial compatibility genes may influence finding a life partner as well as our health and individuality.

Professor Davis said: “We each possess a similar set of around 25,000 human genes. Some of our genes vary from person to person, like those that give us a particular eye or hair colour. But my book is about the few genes – our compatibility genes – that vary the most between each of us. First and foremost these are immune system genes; they control how we combat disease. But recent research shows that they may be even more important than we once thought – there is evidence that they can influence how our brains are wired, how attractive we are, even how likely we are to reproduce.’’ (more…)

Mystery of the mutant polyomavirus

By Guest PostJuly 7, 2013Health, Scienceaaron derdowski, astrocytes, bethany ohara, brain glial cells, brown university, carbohydrate, crystal structure, DNA, gretchen gee, infectious, jc polyomavirus, lstc, luisa ströh, melissa maginnis, mutant form, mutant polyomavirus, myelin, mystery, non infection, oligodendrocytes, pathogen, pml, progressive multifocal leukoencephalopathy, thilo stehle, university of tübingen, ursula neu, vanderbilt university, virus, walter atwood, wild type, xray crystallography

A new study shows that common mutant forms of the deadly JC polyomavirus are not responsible for the pathogen’s main attack, which causes a brain-damaging disease in immunocompromised patients called progressive multifocal leukoencephalopathy. But that finding raises the ominous question of what the mutants might be up to instead.

PROVIDENCE, R.I. [Brown University] — The JC polyomavirus is clearly opportunistic. It infects half the population but lethally destroys brain tissue only in immunocompromised patients — and it may be outright sneaky, too. Even as a new research paper allays fears that common mutant forms of the virus are the ones directly responsible for the disease’s main attack, that same finding raises new questions about what the mutants are doing instead. (more…)

The rhythm of everything

By Guest PostJune 21, 2013General, Health, Scienceadolescents, approximately a day, automobile accidents, blood pressure, body temperature, breast cancer rates, brown university, cancer epidemiology, chronic insomnia, chronobiology international, circa diem, circadian cycle, circadian gene, circadian rhythms, clock, DNA, electric lights, epigenetic changes, estrogen level, feedback loop, habitual fatigue, heart rate, human body, jet lag, key issue, kidneys, logic, molecular autoregulatory, mutation, mysterious, natural processes, physiological phenomena, probably carcinogenic, regulatory genes, rhythm of everything. biological changes, richard g stevens, scientists, seasonal affective disorder, transcriptional activators, ultraviolet light, winter blues, yong zhu

Dawn triggers basic biological changes in the waking human body. As the sun rises, so does heart rate, blood pressure and body temperature. The liver, the kidneys and many natural processes also begin shifting from idle into high gear. Then as daylight wanes and darkness descends, these processes likewise begin to subside, returning to their lowest levels again as we sleep.

These internal biological patterns are tightly linked to an external cosmic pattern: the earth’s rotation around the sun once every 24 hours. This endless loop of light and darkness and the corresponding synchrony of internal and external clocks, are called circadian rhythms, from “circa diem,” Latin for “approximately a day.” Circadian rhythms influence almost all living organisms, from bacteria to algae, insects, birds and, as is increasingly understood by science, humans beings. (more…)