Tag Archives: type 1 diabetes

Cause of genetic disorder found in “dark matter” of DNA

For the first time, scientists have used new technology which analyses the whole genome to find the cause of a genetic disease in what was previously referred to as “junk DNA”.

Pancreatic agenesis results in babies being born without a pancreas, leaving them with a lifetime of diabetes and problems digesting food. 

In a breakthrough for genetic research, teams led by the University of Exeter Medical School and Imperial College London found that the condition is most commonly caused by mutations in a newly identified gene regulatory element in a remote part of the genome, which can now be explored thanks to advances in genetic sequencing. (more…)

Read More

Injectable Nano-Network Controls Blood Sugar in Diabetics for Days at a Time

In a promising development for diabetes treatment, researchers have developed a network of nanoscale particles that can be injected into the body and release insulin when blood-sugar levels rise, maintaining normal blood sugar levels for more than a week in animal-based laboratory tests. The work was done by researchers at North Carolina State University, the University of North Carolina at Chapel Hill, the Massachusetts Institute of Technology and Children’s Hospital Boston.

“We’ve created a ‘smart’ system that is injected into the body and responds to changes in blood sugar by releasing insulin, effectively controlling blood-sugar levels,” says Dr. Zhen Gu, lead author of a paper describing the work and an assistant professor in the joint biomedical engineering program at NC State and UNC Chapel Hill. “We’ve tested the technology in mice, and one injection was able to maintain blood sugar levels in the normal range for up to 10 days.” (more…)

Read More

Despite free health care, household income affects chronic disease control in kids

Researchers at the University of Montreal have found that the glycated hemoglobin levels of children with type 1 diabetes followed at its affiliated Sainte-Justine Mother and Child University Hospital (CHU Sainte-Justine) is correlated linearly and negatively with household income. Glycated hemoglobin is the binding of sugar to blood molecules – over time, high blood sugar levels lead to high levels of glycated hemoglobin, which means that it can be used to assess whether a patient properly controls his or her blood glucose level. “Our study highlights a marked disparity between the rich and the poor in an important health outcome for children with type 1 diabetes, despite free access to health care”, explained Dr. Johnny Deladoëy, who led the study. (more…)

Read More

Youth with diabetes at greater risk following transition from pediatric to adult care

Type 1 diabetes is a condition in which the body does not produce insulin and cannot convert sugar, starches and other food into energy. Generally diagnosed during childhood or adolescence, the disease requires lifelong access to medical care and intensive daily self-management.

As children with Type 1 diabetes grow into young adults, they must leave their pediatric health care providers for adult providers. But the timing of this process and its impact on the young people’s health had not been fully explored. (more…)

Read More

Building Healthy Bones Takes Guts

In what could be an early step toward new treatments for people with osteoporosis, scientists at Michigan State University report that a natural probiotic supplement can help male mice produce healthier bones.

Interestingly, the same can’t be said for female mice, the researchers report in the Journal of Cellular Physiology.

“We know that inflammation in the gut can cause bone loss, though it’s unclear exactly why,” said lead author Laura McCabe, a professor in MSU’s departments of Physiology and Radiology. “The neat thing we found is that a probiotic can enhance bone density.” (more…)

Read More

Researchers Examine New Treatment for Type 1 Diabetes

*Researchers at UM’s Brehm Center for Diabetes Research examines immunotherapy for treatment of ever-increasing cases of type 1 diabetes* 

ANN ARBOR, Mich. – Researchers at the University of Michigan’s Brehm Center for Diabetes Research have received a $3.3 million grant from the National Institutes of Health that could lead to new drug targets for early treatment of type 1 diabetes.

(more…)

Read More