Tag Archives: DNA

Yale Team Finds Order Amidst the Chaos Within the Human Genome; Mom and Dad’s Contributions Counted and Fossil DNA Not Dead After All

By Guest PostSeptember 6, 2012Sciencebiochemically, bottleneck, chao cheng, data mining, DNA, ekta khurana, elements, encode, encyclopedia, evolutionary remnant, fossil dna, gender specific, gene expression, genome, genome dynamic, human genome, joel rozowsky, junk, key function, koon kiu yan, mark gerstein, marker, middle manager, military, model organism, molecular interaction, non coding, protein, pseudogenes, regulation, rnas, social network, statistical model, worm, yale, yale researcher

The Encyclopedia of DNA Elements (ENCODE) project is the effort of hundreds of scientists to describe the workings of the human genome. Their research, outlined in 30 papers published in multiple journals Sept. 5, has confirmed our genome is far more complex than originally thought. Regions that contain instructions for making proteins, which carry out life’s functions, account for only about 1 percent of our genome. ENCODE has shed light on the other 99%. Almost 80 percent of the genome is biochemically active, much of it involved in some sort of regulation of genes. Vast regions of our DNA once considered “junk” contain some 400,000 regulators called enhancers, which play a key role activating or silencing genes despite residing far away from the gene itself. Yale University researchers played a key role ENCODE, helping to author 9 of the 30 papers published in four journals on Sept. 5. Some of their work is described below.

The massive Encyclopedia of DNA Elements (ENCODE) unveiled Sept. 5 reveals a human genome vastly more rich and complex than envisioned even a decade ago. In a key supporting paper published in the journal Nature, the lab of Yale’s Mark Gerstein, the Albert L. Williams Professor of Biomedical Informatics, has found order amidst the seeming chaos of trillions of potential molecular interactions. (more…)

Researchers Share Surprising Discovery about Coral Reef Ecology

By Guest PostSeptember 4, 2012Environment, Natureacidification, algae, algal symbionts, american samoa, climate change, coastal development, coral reef, coral species, coral tissue, david garrison, DNA, ecology, endosymbionts, environment disturbance, environmental change, environmental stress, french polynesia, functional ecosystem, future, generalists, global stressors, hawaii, himb, hollie putnam, host, manoa, moorea, nsf, ocean acidification, photosynthesis, pollution, prediction, reef corals, ruth gates, skeletal growth, skeletons, soest, stresss, symbiodinium, taiwan, temperatures, theory, threat, tissue sample

Researchers at the UH Manoa School of Ocean and Earth Science and Technology (SOEST) made a discovery that challenges a major theory in the field of coral reef ecology.

The general assumption has been that the more flexible corals are, regarding which species of single-celled algae (Symbiodinium) they host in coral tissues, the greater ability corals will have to survive environmental stress. In their paper published August 29, 2012, however, scientists at the Hawaii Institute of Marine Biology (HIMB) at SOEST and colleagues documented that the more flexible corals are, the more sensitive to environment disturbances they are. (more…)

Microbes Help Hyenas Communicate via Scent

By Guest PostSeptember 2, 2012Natureage, animal, animal behavior, bacteria, beneficial relationship, chemical signature, communication, communication system, diversity, DNA, hyena, hyena clan, kay holekamp, kenyan plains, kevin theis, key controller, mammal, michigan state university, microbial community, reproductive status, scent gland, sex, symbiotic bacteria, trait

EAST LANSING, Mich. — Bacteria in hyenas’ scent glands may be the key controllers of communication.

The results, featured in the current issue of Scientific Reports, show a clear relationship between the diversity of hyena clans and the distinct microbial communities that reside in their scent glands, said Kevin Theis, the paper’s lead author and Michigan State University postdoctoral researcher.

“A critical component of every animal’s behavioral repertoire is an effective communication system,” said Theis, who co-authored the study with Kay Holekamp, MSU zoologist. “It is possible that without their bacteria, many animals couldn’t ‘say’ much at all.” (more…)

More Sophisticated Wiring, Not Just a Bigger Brain, Helped Humans Evolve Beyond Chimps

By Guest PostAugust 26, 2012Scienceamino acids, autism, bipolar syndrome, brain disease, brain region, brain tissue, cellular protein, chimp, chimp brain, chimpanzee, circadian rhythm, clock, daniel geschwind, DNA, expression, foxp1, foxp2, frontal cortex, frontal lobe, function, gene manufacture, genevieve konopka, genome, hippocampus, human, human brain, human evolution, human gene, hypothesis, jeremy davis turak, kellen winden, plasticity, schizophrenia, striatum, tara friedrich, ucla

Human and chimp brains look anatomically similar because both evolved from the same ancestor millions of years ago. But where does the chimp brain end and the human brain begin?

A new UCLA study pinpoints uniquely human patterns of gene activity in the brain that could shed light on how we evolved differently than our closest relative. The identification of these genes could improve understanding of human brain diseases like autism and schizophrenia, as well as learning disorders and addictions.

The research appears Aug. 22 in the advance online edition of the journal Neuron. (more…)

Two New Owls Discovered in the Philippines

By Guest PostAugust 22, 2012Natureasian ornithology, birdlife international, birdtour asia, camiguin hawk owl, camiguin sur, cebu, cebu hawk owl, deforestation, discovery, DNA, forest, forktail, island, mammalogy, michigan state university, mindanao, new owls, ninox hawk owls, oriental bird club, pam rasmussen, Philippines, species of owls, vocalization

EAST LANSING, Mich. — Two new species of owls have been discovered in the Philippines, and a Michigan State University researcher played a key role in confirming their existence.

The discovery, which is featured in the current issue of Forktail, the Journal of Asian Ornithology, took years to confirm, but it was well worth the effort, said the paper’s lead author Pam Rasmussen, MSU assistant professor of zoology and assistant curator of mammalogy and ornithology at the MSU Museum.

“More than 15 years ago, we realized that new subspecies of Ninox hawk-owls existed in the Philippines,” she said. “But it wasn’t until last year that we obtained enough recordings that we could confirm that they were not just subspecies, but two new species of owls.” (more…)

Diagnostic Technique Uses Immune Cell DNA

By Guest PostJuly 10, 2012Scienceafrican american, bladder cancer, blood samples, brock christensen, brown university, carmen marsit, cd4, cell carcinoma, cell membrane, chemical alteration, devin koestler, DNA, granulocyte leukocytes, immune cell, karl kelsey, leukocytes, methylation, ovarian cancer, t lymphocytes

By looking at signature chemical differences in the DNA of various immune cells called leukocytes, scientists have developed a way to determine their relative abundance in blood samples. The relative abundance turns out to correlate with specific cancers and other diseases, making the technique, described in two recent papers, potentially valuable not only for research but also for diagnostics and treatment monitoring.

PROVIDENCE, R.I. [Brown University] — When a person is sick, there is a tell-tale sign in their blood: a different mix of the various types of immune cells called leukocytes. A group of scientists at several institutions including Brown University has discovered a way to determine that mix from the DNA in archival or fresh blood samples, potentially providing a practical new technology not only for medical research but also for clinical diagnosis and treatment monitoring of ailments including some cancers. (more…)

Jekyll and Hyde Bacteria Aids or Kills, Depending on Chance

By Guest PostJuly 10, 2012Sciencealex martin, alexander martin, anthony heidt, bacteria, chronic infection, deadly killer, DNA, function, jekyll and hyde, kwi suk kim, michigan state university, microbe, microbiome, microorganism, molecular genetics, pathogen, reproduction, rudolph sloup, todd ciche

EAST LANSING, Mich. — Living in the guts of worms are seemingly innocuous bacteria that contribute to their survival. With a flip of a switch, however, these same bacteria transform from harmless microbes into deadly insecticides.

In the current issue of Science, Michigan State University researchers led a study that revealed how a bacteria flips a DNA switch to go from an upstanding community member in the gut microbiome to deadly killer in insect blood.

Todd Ciche, assistant professor of microbiology and molecular genetics, has seen variants like this emerge sometimes by chance resulting in drastically different properties, such as being lethal to the host or existing in a state of mutual harmony. Even though human guts are more complex and these interactions are harder to detect, the revelation certainly offers new insight that could lead to medical breakthroughs, he said. (more…)

A SMART(er) Way to Track Influenza

By Guest PostJune 12, 2012Scienceaartik sarma, amplification, andrew artenstein, anubhav tripathi, biological debris, brown assay, brown university, carmichael ong, DNA, first aid kit, flu detection test, genetic sequence, H1N1, hiv, influenza rna, influenza rna sequence, iPhone, magnetics, memorial hospital, microfluidics, nasba, nucleic acid sequence, pigs, polymerase chain reaction, prototype, rhode island, rna partners, rna probe, rna strand, smart, smart detector, stephanie mccalla, steven opal, swine flu, tb, tracking of influenza, tuberculosis, united states, virus in mexico

Brown University researchers have created a reliable and fast flu-detection test that can be carried in a first-aid kit. The novel prototype device isolates influenza RNA using a combination of magnetics and microfluidics, then amplifies and detects probes bound to the RNA. The technology could lead to real-time tracking of influenza. Results are published in the Journal of Molecular Diagnostics.

PROVIDENCE, R.I. [Brown University] — In April 2009, the world took notice as reports surfaced of a virus in Mexico that had mutated from pigs and was being passed from human to human. The H1N1 “swine flu,” as the virus was named, circulated worldwide, killing more than 18,000 people, according to the World Health Organization. The Centers for Disease Control and Prevention in the United States said it was the first global pandemic in more than four decades. (more…)