There is no approved medicine to treat polyomaviruses, which afflict people with weakened immune systems, but scientists have found that a chemical compound called Retro-2 is able to reduce significantly the infectivity and spread of the viruses in lab cell cultures. Now they are working to improve it.
PROVIDENCE, R.I. [Brown University] — A team of scientists reports that a small-molecule compound showed significant success in controlling the infectivity and spread of three polyomaviruses in human cell cultures. To date there has been no medicine approved to treat such viruses, which prey on transplant recipients, people with HIV, and others whose immune systems have been weakened. (more…)
One in 2,000 people in the UK are estimated to be carrying variant Creutzfeldt-Jakob disease (vCJD) proteins, according to a study led by Professor Sebastian Brandner (UCL Institute of Neurology).
The research, published in this week’s BMJ, is based on samples from more than 32,000 people and provides the most robust prevalence measure to date. (more…)
Environmental conditions have a much stronger influence on the mix of microbes living in various parts of your body than does competition between species. Instead of excluding each other, microbes that fiercely compete for similar resources are more likely to cohabit in the same individual.
This phenomenon was discovered in a recent study of the human microbiome – the vast collection of our resident bacteria, fungi, and other tiny organisms. (more…)
New Microsoft-commissioned study also highlights dangers for those that use counterfeit software.
REDMOND, Wash. — Although some computer users may actively seek pirated software in hopes of saving money, the chances of infection by unexpected malware are one in three for consumers and three in 10 for businesses, according to a new study commissioned by Microsoft Corp. and conducted by IDC. As a result of these infections, the research shows that consumers will spend 1.5 billion hours and US$22 billion identifying, repairing and recovering from the impact of malware, while global enterprises will spend US$114 billion to deal with the impact of a malware-induced cyberattack.
The global study analyzed 270 websites and peer-to-peer networks, 108 software downloads, and 155 CDs or DVDs, and it interviewed 2,077 consumers and 258 IT managers or chief information officers in Brazil, China, Germany, India, Mexico, Poland, Russia, Thailand, the United Kingdom and the United States. Researchers found that of counterfeit software that does not come with the computer, 45 percent comes from the Internet, and 78 percent of this software downloaded from websites or peer-to-peer networks included some type of spyware, while 36 percent contained Trojans and adware. (more…)
In what could be an early step toward new treatments for people with osteoporosis, scientists at Michigan State University report that a natural probiotic supplement can help male mice produce healthier bones.
Interestingly, the same can’t be said for female mice, the researchers report in the Journal of Cellular Physiology.
“We know that inflammation in the gut can cause bone loss, though it’s unclear exactly why,” said lead author Laura McCabe, a professor in MSU’s departments of Physiology and Radiology. “The neat thing we found is that a probiotic can enhance bone density.” (more…)
UCLA researchers, in a finding that runs counter to conventional wisdom, have discovered for the first time that a gene thought to express a stress-response protein in all cells that come under stress instead expresses the protein only in specific cell types.
The research team, from the Jules Stein Eye Institute at UCLA and the UCLA Division of Pulmonary and Critical Care Medicine, focused on αB-Crystallin, one of a class of molecules known as heat shock proteins, which are involved in the folding and unfolding of other proteins, helping them recover from stress so they can do their job. (more…)
About the video: watch an animation showing the changes in the structure of a T7 virus as it infects an E. coli bacterium.
AUSTIN, Texas — The detailed changes in the structure of a virus as it infects an E. coli bacterium have been observed for the first time, report researchers from The University of Texas at Austin and The University of Texas Health Science Center at Houston (UT Health) Medical School this week in Science Express. (more…)
Misguided killer T cells may be the missing link in sustained tissue damage in the brains and spines of people with multiple sclerosis, findings from the University of Washington reveal. Cytoxic T cells, also known as CD8+ T cells, are white blood cells that normally are in the body’s arsenal to fight disease.
Multiple sclerosis is characterized by inflamed lesions that damage the insulation surrounding nerve fibers and destroy the axons, electrical impulse conductors that look like long, branching projections. Affected nerves fail to transmit signals effectively. (more…)
