A genetic finding could help to explain why influenza becomes a life-threatening disease for some people, and yet has only a mild effect on others. Collaborative research led by scientists at UCL and the Wellcome Trust Sanger Institute found that people who carry a particular variant of the IFITM3 gene are significantly more likely to be hospitalised when they fall ill with influenza than those who carry other variants.
The gene plays a critical role in protecting the body against infection with influenza and a rare version of it appears to make people more susceptible to severe forms of the disease. The results are published in the journal Nature. (more…)
*Study implicates “arms race” between genes and germs*
Biologists have found new evidence of why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs–even though some of those genes make vertebrate animals susceptible to infections and to autoimmune diseases.
“Major histocompatibility complex” (MHC) proteins are found on the surfaces of most cells in vertebrate animals. They distinguish proteins like themselves from foreign proteins, and trigger an immune response against these foreign invaders. (more…)
*Blood test for dogs could lead to similar human test; severe infections kill more than half of patients*
COLUMBIA, Mo. – In pets and people, the time it takes to diagnose an infection may mean life or death. Now, a University of Missouri veterinarian is identifying ways to diagnose pet infections in approximately a third of the current diagnosis time. The resulting test could be used eventually for humans.
“Infections can be difficult to diagnose, and many veterinarians have to send samples to a lab and wait three days or more as the lab attempts to grow a culture,” said Amy DeClue, assistant professor of veterinary internal medicine in the MU College of Veterinary Medicine. “Meanwhile, the infection continues to spread each day that veterinarians wait on lab results, which is detrimental to the patient. In extreme infections, called sepsis, more than half of patients die. My group has been evaluating different blood biomarkers that could give a quick and accurate indication of infection, and we believe we’ve found a biomarker that will only require a simple blood test.” (more…)
If Dr. Laura Niklason has her way, vascular surgeons will someday be able to pull human veins off a shelf, whenever they want, to save lives.
Niklason is a pioneer in the science — and art — of tissue-engineered replacement of human body components. Last year, she led a research team that successfully implanted tissue-engineered lungs, cultured in vitro, in adult rats. For short intervals of time, the engineered lungs exchanged oxygen and carbon dioxide similarly to natural lungs. (more…)
In the early years of the AIDS epidemic, being infected with the virus that causes the disease was considered a virtual death sentence. But with the development of antiretroviral therapy, many with HIV are now living much longer. In fact, it is estimated that by 2015, about half of all HIV-positive individuals will be older than 50. (more…)
ANN ARBOR, Mich.—There are hundreds of millions of new cases of malaria annually, but much of what scientists believe about preventing the spread of malaria in urban settings is mistaken, a new University of Michigan study suggests.
