Tag Archives: immune system

Immune Systems of ‘Bubble Babies’ Restored by Gene Therapy, UCLA Researchers Find

UCLA stem cell researchers have found that a gene therapy regimen can safely restore immune systems to children with so-called “bubble boy” disease, a life-threatening condition that if left untreated can be fatal within one to two years.

In the 11-year study, researchers were able to test two therapy regimens for 10 children with ADA-deficient severe combined immunodeficiency (SCID), which has come to be known as “bubble boy” disease because some of its victims have been forced to live in sterile environments. (more…)

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UCLA Scientists Discover ‘Missing Link’ Between Blood Stem Cells, Immune System

UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.

The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)

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Meditation Reduces Loneliness

UCLA study also finds that mindfulness technique benefits immune system

Many elderly people spend their last years alone. Spouses pass and children scatter. But being lonely is much more than a silent house and a lack of companionship. Over time, loneliness not only takes a toll on the psyche but can have a serious physical impact as well.

Feeling lonely has been linked to an increased risk of heart disease, Alzheimer’s disease, depression and even premature death. Developing effective treatments to reduce loneliness in older adults is essential, but previous treatment efforts have had limited success. (more…)

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Stay Healthy In A Polluted World

Pollution is an unfortunate by-product of our ever-changing society. Air, water and even noise pollution can take a toll on any person’s body, without their knowledge. Fortunately, there ARE ways to fight the effects of pollution in your body, in order to maintain a healthy lifestyle. There are also helpful tips to decrease the toxins that are invading your body, which could potentially cause harmful consequences later in life. Here’s what you need to know!

The Consequences of Pollution

Impure surroundings affect the lungs, heart, cardiovascular system, immune system, and organs when dangerous toxins are inhaled, consumed or absorbed by the skin or airways. Respiratory ailments, such as colds, flu, pneumonia, emphysema and bronchitis occur often because of these. The chances of contracting asthma and COPD or Chronic Obstructive Pulmonary Disease are also more likely. Tainted environments also contribute to allergies, headaches, migraines, and skin disorders such as eczema, acne, melanoma cancer and premature aging. (more…)

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When Cells Hit the Wall: UCLA Engineers Put The Squeeze on Cells to Diagnose Disease

If you throw a rubber balloon filled with water against a wall, it will spread out and deform on impact, while the same balloon filled with honey, which is more viscous, will deform much less. If the balloon’s elastic rubber was stiffer, an even smaller change in shape would be observed.

By simply analyzing how much a balloon changes shape upon hitting a wall, you can uncover information about its physical properties.

Although cells are not simple sacks of fluid, they also contain viscous and elastic properties related to the membranes that surround them; their internal structural elements, such as organelles; and the packed DNA arrangement in their nuclei. Because variations in these properties can provide information about cells’ state of activity and can be indicative of diseases such as cancer, they are important to measure. (more…)

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Why Bad Immunity Genes Survive

*Study implicates “arms race” between genes and germs*

Biologists have found new evidence of why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs–even though some of those genes make vertebrate animals susceptible to infections and to autoimmune diseases.

“Major histocompatibility complex” (MHC) proteins are found on the surfaces of most cells in vertebrate animals. They distinguish proteins like themselves from foreign proteins, and trigger an immune response against these foreign invaders. (more…)

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Gene Research Sheds Light on Timing of Menopause

An international team of researchers has discovered 13 new regions of the genome associated with the timing of menopause.

These genes shed light on the biological pathways involved in reproductive lifespan and will provide insights into conditions connected to menopause, such as breast cancer and heart disease.

Menopause  is a major hormonal change that affects most women when they are in their early 50s. The timing of menopause can have a huge impact on fertility, as well as influencing the risk of a range of common diseases such as breast cancer. It has been known for some time that genetic factors influenced the onset of menopause, however until recently very few genes had been identified.

In the new study, published in the journal Nature Genetics on 22 January 2012, Dr Anna Murray, University of Exeter, Peninsula College of Medicine and Dentistry (PCMD) Dr John Perry, PCMD and WTCHG, University of Oxford, and dozens of international collaborators, examined the genomes of over 50,000 women. They identified 13 novel gene regions associated with menopause onset, and confirmed four previously identified. Most of the 17 regions include genes related to DNA damage/repair or the immune system, whilst others are linked to hormonal regulation. (more…)

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