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A Bug Like a Russian Doll

By Guest PostAugust 20, 2011Scienceanimal metabolism, bacteria, bacterial symbiont, bacterium, carol von dohlen, cytoplasm, dual symbiont systems, human gut, immune system, john mccutcheon, lyle buss, metabolic pathways, moranella, nested symbiosis of mealybugs, relationships between bacteria and citrus mealybugs, relationships between organisms, tremblaya

*A former UA postdoctoral fellow has discovered amazing relationships between organisms: a bacterium living inside a bacterium living inside an insect. Evolving together, the organisms depend on each other for survival, and each contributes a subset of the enzymes needed in shared metabolic pathways.*

Sure, many bacteria cause disease, but most people don’t realize how beneficial they can be. The human gut, for example, brims with bacteria that play critical roles in everything from immune system development and extracting energy from food to providing necessary nutrients.

They get a nice comfy home living inside people, and in return they help us. It’s a symbiotic relationship. However, these beneficial partnerships are nothing compared to the complex relationships between bacteria and citrus mealybugs recently discovered by a team of biologists led by former UA researcher John McCutcheon, who recently took a position as an assistant professor at the University of Montana. (more…)

Is Meditation the Push-up for the Brain?

By Guest PostJuly 16, 2011Health, Scienceage related brain atrophy, amygdale, anterior corpus callosum, axonal demyelination, brain imaging, brain regions, brain stem, brains, bundles of neurons, cerebral cortex, corticospinal tract, diffusion tensor imaging, dti, eileen luders, electrical signals in the brain, frontal cortex, hippocampus, immune system, kristi clark, limbic system, meditation, meditators, mental exercise, micro anatomical level, occipital lobes, physical structure of the brain, shamatha, spinal cord, superior longitudinal fasciculus, uncinate fasciculus, vipassana, white matter, zazen

*Study shows practice may have potential to change brain’s physical structure*

Two years ago, researchers at UCLA found that specific regions in the brains of long-term meditators were larger and had more gray matter than the brains of individuals in a control group. This suggested that meditation may indeed be good for all of us since, alas, our brains shrink naturally with age.

Now, a follow-up study suggests that people who meditate also have stronger connections between brain regions and show less age-related brain atrophy. Having stronger connections influences the ability to rapidly relay electrical signals in the brain. And significantly, these effects are evident throughout the entire brain, not just in specific areas. (more…)

Researchers Discover Way to ‘Amp Up’ Power of Killer T Cells in Immune System

By Guest PostMay 22, 2011Healthanti tumor effector, cancer killing power, immune system, killer cells, toll like receptors

Researchers at UCLA’s Jonsson Comprehensive Cancer Center have discovered a way to “amp up” the power of killer T cells known as CD8 cells in the immune system, making them more functional for longer periods of time and boosting their ability to multiply and expand within the body to fight melanoma. (more…)

It Takes a Community of Soil Microbes to Protect Plants From Disease

By Guest PostMay 15, 2011Environment, Scienceactinobacteria, archaea, bacteria, berkeley lab, burkholderia, complex microbial network, coral reefs, deepwater horizon spill, disease, dna sequences, dutch scientists, environmental mysteries, gary andersen, gulf of mexico, immune system, mammals, pathogens, phylochip, plants, potato, psuedomonas, puerto rico, rathmann family foundation, rhizoctonia solani, rice, root fungus, soil, soil microbes, sugar beet, todd desantis, types of bacteria, vegetables, xanthomonas, yvette piceno

*Berkeley Lab scientists decipher immune system for plants beneath our feet*

Those vegetables you had for dinner may have once been protected by an immune system akin to the one that helps you fight disease. Scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the Netherland’s Wageningen University found that plants rely on a complex community of soil microbes to defend themselves against pathogens, much the way mammals harbor a raft of microbes to avoid infections.

The scientists deciphered, for the first time, the group of microbes that enables a patch of soil to suppress a plant-killing pathogen. Previous research on the phenomenon of disease-suppressive soil had identified one or two pathogen-fighting microbes at work. (more…)

Polluted Air Leads To Disease by Promoting Widespread Inflammation

By Guest PostApril 20, 2011Environment, Healthanimal model, cellular activity, chronic inhalation, enzyme, exposure to pollution, il-12, immune system, inflammation, inflammatory monocytes, interleukin-12, mcp-1, monocyte chemoattractant protein, monocytes, nadph oxidase, ohio state university, polluted air, protein, sanjay rajagopalan, thomas kampfrath, tlr4, tnfa, toll-like receptor 4, tumor necrosis factor alpha, white blood cells

COLUMBUS, Ohio – Chronic inhalation of polluted air appears to activate a protein that triggers the release of white blood cells, setting off events that lead to widespread inflammation, according to new research in an animal model.

This finding narrows the gap in researchers’ understanding of how prolonged exposure to pollution can increase the risk for cardiovascular problems and other diseases. (more…)

Berkeley Lab Scientists Find That Normal Breast Cells Help Kill Cancer Cells

By Guest PostApril 20, 20111 commentHealth, Scienceberkeley lab, breast cancer cells, cytostatic, cytotoxic, dna mutations, extracellular matrix culture, healthy cells, human body, il25, immune system, inflammation, interleukin 25, malignant phenotype, mammary epithelial cells, microenvironmental factors, mina bissell, natural defense mechanism against cancer, pathogens, protein, saori furuta, treatment of breast cancer, tumor cells, tumor surveillance system

It is well known that the human body has a highly developed immune system to detect and destroy invading pathogens and tumor cells. Now, researchers at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have shown that the body has a second line of defense against cancer – healthy cells. A new study shows that normal mammary epithelial cells, as they are developing, secrete interleukin 25, a protein known for its role in the immune system’s response to inflammation, for the express purpose of killing nearby breast cancer cells.

“We found that normal breast cells provide an innate defense mechanism against cancer by producing interleukin 25 (IL25) to actively and specifically kill breast cancer cells,” says breast cancer authority Mina Bissell, of Berkeley Lab’s Life Sciences Division, who led this research. “This suggests that IL25 receptor signaling may provide a new therapeutic target for the treatment of breast cancer.” (more…)

UF Researchers Suspect Bacterial Changes in Mouth Promote Oral Disease in People With HIV

By Guest PostMarch 19, 2011Healthbacterial communities, chronic periodontitis, clay walker, gary wang, hiv infected patients, immune system, microbial signature, oral biota, oral microorganisms

GAINESVILLE, Fla. — Oral disease occurs commonly and progresses rapidly among people who have HIV, but the process is poorly understood. Researchers suspect that the culprit is a change in the makeup of bacterial communities that live in the mouth. (more…)

Antibiotic Use in Infancy May Increase Risk of Childhood Asthma

By Guest PostJanuary 9, 20111 commentHealth, Scienceantibiotic use, antibiotics, childhood asthma, children, developing asthma, genetic predisposition, hygiene hypothesis, immune system, kari risnes, kathleen belanger, low risk children, michael b bracken, microbial exposure, risk of asthma, william murk, yale study

Children who receive antibiotics within the first six months of life are at a significantly increased risk of developing asthma and allergies by 6 years of age, even without a genetic predisposition, new research by the Yale School of Public Health suggests. The findings are reported online in the American Journal of Epidemiology. (more…)

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