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Study in Mice Raises Question: Could PTSD Involve Immune Cell Response to Stress?

By Guest PostMarch 8, 2014Scienceanxiety, anxiety like behavior, behavioral marker, behavioral terms, cellular component, central nervous system, chronic stress, immune cell response, inflammation, inflammatory immune response, john sheridan, jonathan godbout, monocytes, monocytes in brain, mood disorders, ohio state university, post traumatic, pro inflammatory proteins, ptsd, single acute stressor, stress, stress disorder, study in mice, symptom

After chronic stress, primed immune cells in spleen lead to excessive reaction to later event

COLUMBUS, Ohio – Chronic stress that produces inflammation and anxiety in mice appears to prime their immune systems for a prolonged fight, causing the animals to have an excessive reaction to a single acute stressor weeks later, new research suggests.

After the mice recovered from the effects of chronic stress, a single stressful event 24 days later quickly returned them to a chronically stressed state in biological and behavioral terms. Mice that had not experienced the chronic stress were unaffected by the single acute stressor. (more…)

Scientists Identify Novel Pathway for T Cell Activation in Leprosy

By Guest PostApril 2, 2012Sciencecell signaling molecule, delphine j lee, dendritic cells, immune cells, infection, interleukin 32, lepromatous leprosy, leprosy, leprosy pathogen, mirjam schenk, monocytes, mycobacteria, mycobacterium leprae, nod2, peter a sieling, protein, robert modlin, skin, stephan r krutzik, t cells, tlr2, tuberloid leprosy, white blood cell

*Findings may help lead to new treatments for infectious diseases, cancer*

UCLA researchers have pinpointed a new mechanism that potently activates T cells, the group of white blood cells that plays a major role in fighting infections.

The team specifically studied how dendritic cells, immune cells located at the site of an infection, become more specialized to fight the leprosy pathogen known as Mycobacterium leprae. Dendritic cells, like scouts in the field of a military operation, deliver key information about an invading pathogen that helps activate the T cells in launching a more effective attack. (more…)

Polluted Air Leads To Disease by Promoting Widespread Inflammation

By Guest PostApril 20, 2011Environment, Healthanimal model, cellular activity, chronic inhalation, enzyme, exposure to pollution, il-12, immune system, inflammation, inflammatory monocytes, interleukin-12, mcp-1, monocyte chemoattractant protein, monocytes, nadph oxidase, ohio state university, polluted air, protein, sanjay rajagopalan, thomas kampfrath, tlr4, tnfa, toll-like receptor 4, tumor necrosis factor alpha, white blood cells

COLUMBUS, Ohio – Chronic inhalation of polluted air appears to activate a protein that triggers the release of white blood cells, setting off events that lead to widespread inflammation, according to new research in an animal model.

This finding narrows the gap in researchers’ understanding of how prolonged exposure to pollution can increase the risk for cardiovascular problems and other diseases. (more…)

Tag Archives: monocytes

Study in Mice Raises Question: Could PTSD Involve Immune Cell Response to Stress?

Scientists Identify Novel Pathway for T Cell Activation in Leprosy

Polluted Air Leads To Disease by Promoting Widespread Inflammation