The real killer behind cancer
This story is short. Not much is known about metastasis.
And that’s the point. (more…)
Tag Archives: immune system
IRCM scientists find a novel research model for the study of auto-immune diseases
A team of researchers at the IRCM, led by Dr. Javier M. Di Noia in the Immunity and Viral Infections research division, discovered a novel research model for the study of auto-immune diseases. The Montréal scientists are the first to find a way to separate two important mechanisms that improve the quality of antibodies. This study was featured in a recent issue of The Journal of Immunology. (more…)
Scientists Reveal Quirky Feature of Lyme Disease Bacteria
Unlike most organisms, they don’t need iron, but they crave manganese
Scientists have confirmed that the pathogen that causes Lyme Disease—unlike any other known organism—can exist without iron, a metal that all other life needs to make proteins and enzymes. Instead of iron, the bacteria substitute manganese to make an essential enzyme, thus eluding immune system defenses that protect the body by starving pathogens of iron.
To cause disease, Borrelia burgdorferi requires unusually high levels of manganese, scientists at Johns Hopkins University (JHU), Woods Hole Oceanographic Institution (WHOI), and the University of Texas reported. Their study, published March 22, 2013, in The Journal of Biological Chemistry, may explain some mysteries about why Lyme Disease is slow-growing and hard to detect and treat. The findings also open the door to search for new therapies to thwart the bacterium by targeting manganese. (more…)
Building Healthy Bones Takes Guts
In what could be an early step toward new treatments for people with osteoporosis, scientists at Michigan State University report that a natural probiotic supplement can help male mice produce healthier bones.
Interestingly, the same can’t be said for female mice, the researchers report in the Journal of Cellular Physiology.
“We know that inflammation in the gut can cause bone loss, though it’s unclear exactly why,” said lead author Laura McCabe, a professor in MSU’s departments of Physiology and Radiology. “The neat thing we found is that a probiotic can enhance bone density.” (more…)
New Details on the Molecular Machinery of Cancer
Berkeley Lab Researchers Resolve EGFR Activation Mystery
Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.
“The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer,” says chemist Jay Groves, one of the leaders of this research. “Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we’ve determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand.” (more…)
Vitamin D, Omega-3 May Help Clear Amyloid Plaques Found in Alzheimer’s
A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system’s ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer’s disease.
In a small pilot study published in the Feb. 5 issue of the Journal of Alzheimer’s Disease, the scientists identified key genes and signaling networks regulated by vitamin D3 and the omega-3 fatty acid DHA (docosahexaenoic acid) that may help control inflammation and improve plaque clearance. (more…)
Native Delaware: Parenting’s toll
Stewart studies birds to understand trade-offs between reproduction, immunity
Does parenting take a toll on the immune system?
If you’ve ever been the parent of a newborn who demanded to be fed every three to four hours, your gut instinct tells you the answer is an absolute, unequivocal yes.
University of Delaware post-doctoral researcher Ian Stewart is conducting research to answer this question a bit more scientifically. His subjects – tree swallows – make human parents look like slouches. Both the mother and father tree swallow feed their hatchlings every five minutes, 12 hours a day. (It should be noted, though, that their parenting gig is much shorter than ours — after 17 or 18 days the young leave the nest.) (more…)
Studies: Pigs Look Healthy But Test Positive for Flu at Fairs; Flu Transmission Seen Between Pigs and Humans
COLUMBUS, Ohio – More than 80 percent of pigs that tested positive for influenza A virus at Ohio county fairs between 2009 and 2011 showed no signs of illness, according to a new study.
Ohio State University researchers tested 20 pigs each at 53 fair events over those three summers and found at least one flu-positive pig at 12 fairs – almost a quarter of fairs tested. (more…)