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Researchers Create Flexible, Nanoscale ‘Bed of Nails’ for Possible Drug Delivery

Researchers at North Carolina State University have come up with a technique to embed needle-like carbon nanofibers in an elastic membrane, creating a flexible “bed of nails” on the nanoscale that opens the door to development of new drug-delivery systems.

The research community is interested in finding new ways to deliver precise doses of drugs to specific targets, such as regions of the brain. One idea is to create balloons embedded with nanoscale spikes that are coated with the relevant drug. Theoretically, the deflated balloon could be inserted into the target area and then inflated, allowing the spikes on the balloon’s surface to pierce the surrounding cell walls and deliver the drug. The balloon could then be deflated and withdrawn. (more…)

When Cells Hit the Wall: UCLA Engineers Put The Squeeze on Cells to Diagnose Disease

By Guest PostMay 6, 2012Health, Scienceaids, amander clark, balloon, cancer, cells, chemical tags, chronic inflammation, cytopathologist, daniel gossett, deformability cytometer, diagnose disease, dino di carlo, dna arrangement, elastic properties, extract information, henry tse, honey, immune disorder, immune system, infection, jian yu rao, mesothelial cells, microfluidic chip, nuclei, rubber balloon, shape, software, steven chu, Technology, ucla engineers, viscous, white blood cells

If you throw a rubber balloon filled with water against a wall, it will spread out and deform on impact, while the same balloon filled with honey, which is more viscous, will deform much less. If the balloon’s elastic rubber was stiffer, an even smaller change in shape would be observed.

By simply analyzing how much a balloon changes shape upon hitting a wall, you can uncover information about its physical properties.

Although cells are not simple sacks of fluid, they also contain viscous and elastic properties related to the membranes that surround them; their internal structural elements, such as organelles; and the packed DNA arrangement in their nuclei. Because variations in these properties can provide information about cells’ state of activity and can be indicative of diseases such as cancer, they are important to measure. (more…)

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Researchers Create Flexible, Nanoscale ‘Bed of Nails’ for Possible Drug Delivery

When Cells Hit the Wall: UCLA Engineers Put The Squeeze on Cells to Diagnose Disease