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Researchers Create Flexible, Nanoscale ‘Bed of Nails’ for Possible Drug Delivery

Researchers at North Carolina State University have come up with a technique to embed needle-like carbon nanofibers in an elastic membrane, creating a flexible “bed of nails” on the nanoscale that opens the door to development of new drug-delivery systems.

The research community is interested in finding new ways to deliver precise doses of drugs to specific targets, such as regions of the brain. One idea is to create balloons embedded with nanoscale spikes that are coated with the relevant drug. Theoretically, the deflated balloon could be inserted into the target area and then inflated, allowing the spikes on the balloon’s surface to pierce the surrounding cell walls and deliver the drug. The balloon could then be deflated and withdrawn. (more…)

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Researchers Find Gold Nanoparticles Capable of ‘Unzipping’ DNA

New research from North Carolina State University finds that gold nanoparticles with a slight positive charge work collectively to unravel DNA’s double helix. This finding has ramifications for gene therapy research and the emerging field of DNA-based electronics.

“We began this work with the goal of improving methods of packaging genetic material for use in gene therapy,” says Dr. Anatoli Melechko, an associate professor of materials science and engineering at NC State and co-author of a paper describing the research. Gene therapy is an approach for addressing certain medical conditions by modifying the DNA in relevant cells. (more…)

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