COLUMBUS, Ohio – Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer’s disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer’s disease.
That is the most dramatic reduction in this compound reported to date in published research.
The compounds are amyloid beta, or A-beta peptides; peptides are proteins, but are shorter in length. When A-beta peptides accumulate in excessive amounts in the brain, they can form plaques, which are a hallmark of Alzheimer’s disease. (more…)
Berkeley Lab-led Observations of Electron Hopping in Iron Oxide Hold Consequences for Environment and Energy
Rust – iron oxide – is a poor conductor of electricity, which is why an electronic device with a rusted battery usually won’t work. Despite this poor conductivity, an electron transferred to a particle of rust will use thermal energy to continually move or “hop” from one atom of iron to the next. Electron mobility in iron oxide can hold huge significance for a broad range of environment- and energy-related reactions, including reactions pertaining to uranium in groundwater and reactions pertaining to low-cost solar energy devices. (more…)
The most-studied mass extinction in Earth history happened 65 million years ago and is widely thought to have wiped out the dinosaurs. New University of Washington research indicates that a separate extinction came shortly before that, triggered by volcanic eruptions that warmed the planet and killed life on the ocean floor.
The well-known second event is believed to have been triggered by an asteroid at least 6 miles in diameter slamming into Mexico’s Yucatán Peninsula. But new evidence shows that by the time of the asteroid impact, life on the seafloor – mostly species of clams and snails – was already perishing because of the effects of huge volcanic eruptions on the Deccan Plateau in what is now India. (more…)
New and Improved Model of Molecular Bonding from Researchers at Berkeley Lab’s Molecular Foundry
Material properties and interactions are largely determined by the binding and unbinding of their constituent molecules, but the standard model used to interpret data on the formation and rupturing of molecular bonds suffers from inconsistencies. A collaboration of researchers led by a scientist at the U.S Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a first-of-its-kind model for providing a comprehensive description of the way in which molecular bonds form and rupture. This model enables researchers to predict the “binding free energy” of a given molecular system, which is key to predicting how that molecule will interact with other molecules.
“Molecular binding and unbinding events are much simpler than we have been led to believe from the standard model over the past decade,” says Jim DeYoreo, a scientist with the Molecular Foundry, a DOE nanoscience center at Berkeley Lab who was one of the leaders of this research. “With our new model, we now have a clear means for measuring one of the most important parameters governing how materials and molecules bind together.” (more…)
The Encyclopedia of DNA Elements (ENCODE) project is the effort of hundreds of scientists to describe the workings of the human genome. Their research, outlined in 30 papers published in multiple journals Sept. 5, has confirmed our genome is far more complex than originally thought. Regions that contain instructions for making proteins, which carry out life’s functions, account for only about 1 percent of our genome. ENCODE has shed light on the other 99%. Almost 80 percent of the genome is biochemically active, much of it involved in some sort of regulation of genes. Vast regions of our DNA once considered “junk” contain some 400,000 regulators called enhancers, which play a key role activating or silencing genes despite residing far away from the gene itself. Yale University researchers played a key role ENCODE, helping to author 9 of the 30 papers published in four journals on Sept. 5. Some of their work is described below.
The massive Encyclopedia of DNA Elements (ENCODE) unveiled Sept. 5 reveals a human genome vastly more rich and complex than envisioned even a decade ago. In a key supporting paper published in the journal Nature, the lab of Yale’s Mark Gerstein, the Albert L. Williams Professor of Biomedical Informatics, has found order amidst the seeming chaos of trillions of potential molecular interactions. (more…)
UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.
The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)
The Pink Double Dandy peony, the Double Peppermint petunia, the Doubled Strawberry Vanilla lily and nearly all roses are varieties cultivated for their double flowers.
The blossoms of these and other such plants are lush with extra petals in place of the parts of the flower needed for sexual reproduction and seed production, meaning double flowers – though beautiful – are mutants and usually sterile.
The genetic interruption that causes that mutation helped scientists in the 1990s pinpoint the genes responsible for normal development of sexual organs stamens and carpels in the plant Arabidopsis thaliana, long used as a plant model by biologists. (more…)
Berkeley Lab scientists and their colleagues have successfully probed the effects of light at the atomic scale by mixing x-ray and optical light waves at the Linac Coherent Light Source
Light changes matter in ways that shape our world. Photons trigger changes in proteins in the eye to enable vision; sunlight splits water into hydrogen and oxygen and creates chemicals through photosynthesis; light causes electrons to flow in the semiconductors that make up solar cells; and new devices for consumers, industry, and medicine operate with photons instead of electrons. But directly measuring how light manipulates matter on the atomic scale has never been possible, until now.(more…)
