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Forcing the Molecular Bond Issue

By Guest PostSeptember 6, 2012Scienceadsorb, aerosol droplets, aleksandr noy, antibody, berkeley lab, binding free energy, biosensing assay, data, dfs, dynamic force spectroscopy, energy barrier, force spectra, formation, interaction, intermolecular bond, jim deyoreo, material, molecular bond, molecular foundry, molecular system, molecule, nanoscience center, nonlinear force, property, raymond friddle, rupture, single bond model, standard model, synthetic analogue, synthetic polymer, torsional force

New and Improved Model of Molecular Bonding from Researchers at Berkeley Lab’s Molecular Foundry

Material properties and interactions are largely determined by the binding and unbinding of their constituent molecules, but the standard model used to interpret data on the formation and rupturing of molecular bonds suffers from inconsistencies. A collaboration of researchers led by a scientist at the U.S Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a first-of-its-kind model for providing a comprehensive description of the way in which molecular bonds form and rupture. This model enables researchers to predict the “binding free energy” of a given molecular system, which is key to predicting how that molecule will interact with other molecules.

“Molecular binding and unbinding events are much simpler than we have been led to believe from the standard model over the past decade,” says Jim DeYoreo, a scientist with the Molecular Foundry, a DOE nanoscience center at Berkeley Lab who was one of the leaders of this research. “With our new model, we now have a clear means for measuring one of the most important parameters governing how materials and molecules bind together.” (more…)

Yale Team Finds Order Amidst the Chaos Within the Human Genome; Mom and Dad’s Contributions Counted and Fossil DNA Not Dead After All

By Guest PostSeptember 6, 2012Sciencebiochemically, bottleneck, chao cheng, data mining, DNA, ekta khurana, elements, encode, encyclopedia, evolutionary remnant, fossil dna, gender specific, gene expression, genome, genome dynamic, human genome, joel rozowsky, junk, key function, koon kiu yan, mark gerstein, marker, middle manager, military, model organism, molecular interaction, non coding, protein, pseudogenes, regulation, rnas, social network, statistical model, worm, yale, yale researcher

The Encyclopedia of DNA Elements (ENCODE) project is the effort of hundreds of scientists to describe the workings of the human genome. Their research, outlined in 30 papers published in multiple journals Sept. 5, has confirmed our genome is far more complex than originally thought. Regions that contain instructions for making proteins, which carry out life’s functions, account for only about 1 percent of our genome. ENCODE has shed light on the other 99%. Almost 80 percent of the genome is biochemically active, much of it involved in some sort of regulation of genes. Vast regions of our DNA once considered “junk” contain some 400,000 regulators called enhancers, which play a key role activating or silencing genes despite residing far away from the gene itself. Yale University researchers played a key role ENCODE, helping to author 9 of the 30 papers published in four journals on Sept. 5. Some of their work is described below.

The massive Encyclopedia of DNA Elements (ENCODE) unveiled Sept. 5 reveals a human genome vastly more rich and complex than envisioned even a decade ago. In a key supporting paper published in the journal Nature, the lab of Yale’s Mark Gerstein, the Albert L. Williams Professor of Biomedical Informatics, has found order amidst the seeming chaos of trillions of potential molecular interactions. (more…)

UCLA Scientists Discover ‘Missing Link’ Between Blood Stem Cells, Immune System

By Guest PostSeptember 5, 2012Health, Scienceblood, blood lineage, bone marrow, cell, diseases, gay crooks, gene, haystack, human, immune deficiency, immune function, immune system, infection, leukemia, lisa kohn, lymphocytes, missing link, needle, platelets, post natal life, progenitors, red blood cell, researcher, set, stem cell, type, ucla

UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.

The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)

Synchronized Lasers Measure How Light Changes Matter

By Guest PostSeptember 4, 2012Scienceatomic scale, effects of light, light changes matter, optical pulse, sum frequency generation, synchronized lasers

Berkeley Lab scientists and their colleagues have successfully probed the effects of light at the atomic scale by mixing x-ray and optical light waves at the Linac Coherent Light Source

Light changes matter in ways that shape our world. Photons trigger changes in proteins in the eye to enable vision; sunlight splits water into hydrogen and oxygen and creates chemicals through photosynthesis; light causes electrons to flow in the semiconductors that make up solar cells; and new devices for consumers, industry, and medicine operate with photons instead of electrons. But directly measuring how light manipulates matter on the atomic scale has never been possible, until now. (more…)

Storm-chasing Spacecraft

By Guest PostSeptember 3, 2012Scienceintensity of radiation, radiation belt, radiation belt particles, soviet nuclear test, van allen belts

A U-led experiment flies on a NASA mission to Earth’s radiation belts

The story goes that when Earth’s Van Allen Radiation Belts were first discovered, scientists were so amazed by the intensity of radiation, they thought they’d stumbled onto a Soviet nuclear test. (more…)

NASA, Texas Astronomers Find First Multi-Planet System Around a Binary Star

By Guest PostSeptember 3, 2012Scienceaustin, bill cochran, binary star, caroline caldwell, faint star, giant magellan telescope, habitable zone, harlan j smith, het, hobby eberly telescope, jerome orosz, kepler 47, kepler mission, largest telescope, m dwarf star, mcdonald observatory, michael endl, multi planet, NASA, one system, planet, primary star, san diego, secondary star, solar system, space telescope, state university, stellar eclipse, sun, tatooine, telescope, texas, transit, university, west texas, william welsh, world

FORT DAVIS, Texas — NASA’s Kepler mission has found the first multi-planet solar system orbiting a binary star, characterized in large part by University of Texas at Austin astronomers using two telescopes at the university’s McDonald Observatory in West Texas. The finding, which proves that whole planetary systems can form in a disk around a binary star, is published in today’s issue of the journal Science.

“It’s Tatooine, right?” said McDonald Observatory astronomer Michael Endl. “But this was not shown in Star Wars,” he said, referring to the periodic changes in the amount of daylight falling on a planet with two suns. Measurements of the star’s orbits showed that daylight on the planets would vary by a large margin over the 7.4-Earth-day period as the two stars completed their mutual orbits, each moving closer to, then farther from, the planets (which are themselves moving). (more…)

Researchers Develop New, Less Expensive Nanolithography Technique

By Guest PostSeptember 3, 2012Scienceabsorb, albena ivanisevic, approach, biomedical application, chapel hill, humidity, marcus a kramer, micron, nanolithography, nanoscale, north Carolina, polymer, silicon strip, spore, state university, substrate surface, surface, technique, water

Researchers from North Carolina State University have developed a new nanolithography technique that is less expensive than other approaches and can be used to create technologies with biomedical applications.

“Among other things, this type of lithography can be used to manufacture chips for use in biological sensors that can identify target molecules, such as proteins or genetic material associated with specific medical conditions,” says Dr. Albena Ivanisevic, co-author of a paper describing the research. Ivanisevic is an associate professor of materials science and engineering at NC State and associate professor of the joint biomedical engineering program at NC State and the University of North Carolina at Chapel Hill. Nanolithography is a way of printing patterns at the nanoscale. (more…)

Finding Faults

By Guest PostSeptember 2, 2012Environment, Sciencecalvert formation, delaware, dgs, earthquake, eocene, evidence, fault surface, fault zone, finding faults, geologic record, geological survey, grooves and steps, magnitude, miocene, new castle, northern delaware, occurrence, parallel grooves, past earthquake, piney point formation, scott andres, sediment sample, slickensides, smyrna, university of delaware, virginia, well drilling, wildlife area, woodland beach

Delaware Geological Survey discovers evidence of past earthquakes

Delaware Geological Survey (DGS) scientists have uncovered hard proof of faults in northern Delaware, indicating the occurrence of earthquakes millions of years ago.

The geologic evidence turned up in sediment samples removed during a well-drilling project this summer from depths ranging 137 to 251 feet down in Smyrna and the Woodland Beach Wildlife Area.

“People have postulated that there are faults in this area,” DGS Senior Scientist Scott Andres said. “Now we have evidence of it.” (more…)

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