Paper describes new method to understand sources of noise in gene-expression
Abhyudai Singh, assistant professor of electrical and computer engineering at the University of Delaware, describes a new method to understand sources of “noise” in gene-expression that create variability in protein levels in a paper published in Molecular Systems Biology, a publication of Nature, on Aug. 28.
This noise is expressed as variability in the levels of proteins/mRNAs in a cell. (more…)
In a new study, Brown University researchers demonstrate a new tool for visually tracking in real-time the transformation of a living population of stem cells into cells of a specific tissue. The “molecular beacons,” which could advance tissue engineering research, light up when certain genes are expressed and don’t interfere with the development or operation of the stem cells.
PROVIDENCE, R.I. [Brown University] — A novel set of custom-designed “molecular beacons” allows scientists to monitor gene expression in living populations of stem cells as they turn into a specific tissue in real-time. The technology, which Brown University researchers describe in a new study, provides tissue engineers with a potentially powerful tool to discover what it may take to make stem cells transform into desired tissue cells more often and more quickly. That’s a key goal in improving regenerative medicine treatments. (more…)
UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.
The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)
COLUMBUS, Ohio – Some RNA molecules spend time in a restful state akin to hibernation rather than automatically carrying out their established job of delivering protein-building instructions in cells, new research suggests.
And instead of being a fluke or a mistake, the research suggests that this restful period appears to be a programmed step for RNA produced by certain types of genes, including some that control cell division and decide where proteins will work in a cell to sustain the cell’s life.
This could mean that protein production in cells is not as clear-cut as biology textbooks suggest, scientists say. (more…)
A recent review of research co-authored by Rose McDermott highlights the role that genes play in political preferences, an area of study that began to draw significant attention in the last decade. McDermott speaks with Courtney Coelho about this growing field of research, its evolutionary roots, and whether it means anything for the prediction of future election results.
The connection between biology and political science is relatively new, but it’s one that has grown rapidly, with a boom in research linking genetics and political preferences in the last decade. Rose McDermott, professor of political science, has done research on this topic and recently co-authored a review, published in Trends in Genetics, of studies in recent years. (more…)
EAST LANSING, Mich. — Mechanisms that protect plants from freezing are placed in storage during the summer and wisely unpacked when days get shorter.
In the current issue of the Proceedings of the National Academy of Sciences, Michael Thomashow, University Distinguished Professor of molecular genetics, demonstrates how the CBF (C-repeat binding factor) cold response pathway is inactive during warmer months when days are long, and how it’s triggered by waning sunlight to prepare plants for freezing temperatures. (more…)
Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs — a single genetic switch that triggers loss of brain connections in humans and depression in animal models.
The findings, reported in the Aug. 12 issue of the journal Nature Medicine, show that the genetic switch known as a transcription factor represses the expression of several genes that are necessary for the formation of synaptic connections between brain cells, which in turn could contribute to loss of brain mass in the prefrontal cortex. (more…)
UD’s Schmidt studies genome of crocodile family in evolution research
University of Delaware scientist Carl Schmidt is working to identify genes in crocodiles, alligators and gharials as he searches for links between the creatures that could give clues as to how they evolved over the years in relation to one another.
Schmidt’s effort is part of a National Science Foundation-funded project being conducted by a team of researchers assembled by David Ray, an evolutionary biologist at Mississippi State University. (more…)
