Tag Archives: gene

Genome-wide Atlas of Gene Enhancers in the Brain On-line

By Guest PostFebruary 6, 2013Scienceautism, axel visel, basal ganglia, berkeley lab, biological functions, brain on line, cerebral cortex, cerebrum, chip seq studies, chromatin immunoprecipitation, cognition, collection of data, dalit may, dna basepairs, dna elements, embryonic forebrain, emotion, epilepsy, evolution, gene, gene enhancers, gene regulating elements, gene regulatory functions, genetic mutations, genome wide atlas, gray matter, hani girgis, human brain, human diseases, junk dna, leila taher, molecular toolbox, motor functions, neurological disorders, non coding mutation, olga golonzhka, protein coding genes, schizophrenia, sequences of dna, telencephalon

Collaboration Led by Berkeley Lab Researchers Creates High-Resolution Map of Gene Regulatory Elements in the Brain

Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas, developed by a team led by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) is a publicly accessible Web-based collection of data that identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.

“Understanding how the brain develops and functions, and how it malfunctions in neurological disorders, remains one of the most daunting challenges in contemporary science,” says Axel Visel, a geneticist with Berkeley Lab’s Genomics Division. “We’ve created a genome-wide digital atlas of gene enhancers in the human brain – the switches that tell genes when and where they need to be switched on or off. This enhancer atlas will enable other scientists to study in more detail how individual genes are regulated during development of the brain, and how genetic mutations may impact human neurological disorders.” (more…)

Lack of Key Enzyme in the Metabolism of Folic Acid Leads to Birth Defects

By Guest PostJanuary 23, 2013Healthanencephaly, austin, birth defects, dean appling, developing embryos, folic acid, folic acid enzyme, formate, gene, human gene, jessica momb, jordan lewandowski, joshua bryant, key enzyme, lack, metabolic pathway, metabolism, mthfd1l, mutation, neural tube defects, point mutation, pregnancy, rebecca fitch, researcher deborah surman, spina bifida, steven vokes, university of texas

AUSTIN, Texas — Researchers at The University of Texas at Austin have discovered that the lack of a critical enzyme in the folic acid metabolic pathway leads to neural tube birth defects in developing embryos.

It has been known for several decades that folic acid supplementation dramatically reduces the incidence of neural tube defects, such as spina bifida and anencephaly, which are among the most common birth defects. In some populations, folic acid supplementation has decreased neural tube defects by as much as 70 percent. (more…)

Born to Lead? Leadership Can be an Inherited Trait, Study Finds

By Guest PostJanuary 18, 2013Politics, Scienceassessment, Barack Obama, born to lead, child, de neve, democratic primary, dna sequence, economic, framingham heart study, garfld986, gene, genetic difference, genetic discrimination, genetic trait, genotype, harvard, hillary clinton, inherited trait, jan emmanuel, leadership, leadership behaviour, leadership position, leadership skills, learning environment, new hampshire, nyu, political outcomes, professor john antonakis, rs4950, selection, tendency, ucl, unite for change, united states, university college london, university of california, variation, workplace

Genetic differences are significantly associated with the likelihood that people take on managerial responsibilities, according to new research from UCL (University College London).

The study, published online in Leadership Quarterly, is the first to identify a specific DNA sequence associated with the tendency for individuals to occupy a leadership position. Using a large twin sample, the international research team, which included academics from Harvard, NYU, and the University of California, estimate that a quarter of the observed variation in leadership behaviour between individuals can be explained by genes passed down from their parents. (more…)

Better Way to Understand Plasmid Cloning from AddGene

By Guest PostJanuary 17, 2013Scienceaddgene, ailments, backbone vector, biologically engineered, chromosomes, circular fragments, cloning process, cloning vital organs, digestion, dna strands, double stranded dna, first successful cloning, gel purification, gene, manipulating genes, medical research, molecular cloning, molecular level, molecule cloning, molly the sheep, non profit repository, original chromosomal dna, pcr, plasmid cloning, plasmid land, plasmids, prolong human life, red, red cloning, repository, restriction enzyme digest, restructure diseases, scottish lambs, sub cloning, vector

Medical research has been studying molecular cloning for centuries. While many remember the Scottish lambs as the first successful cloning, there have been countless medical advances since then. Many of them are not as evident or dramatic as Molly the sheep, they have been blazing the trail for cloning vital organs, DNA strands and chromosomes in hopes of curtailing or even curing the maladies that plague the human race. Plasmids are at the forefront of this research in hopes they can learn how to insert DNA strands and restructure diseases or ailments on a molecular level.

It is difficult to describe what Plasmid is exactly. Plasmid is a biologically engineered DNA strands that are meant to be used in existing organisms as well as creating new ones. There are many aspects of it used in different ways from molecule cloning, manipulating genes or advancing medical research. Plasmids are circular fragments of double-stranded DNA. Plasmids are used in DNA strands and they can be replicated independently of original chromosomal DNA that created them. While they are mainly used for studying purposes at the moment in biological laboratories, they are meant to advance medical research and hopefully be used to prolong human life. (more…)

Previous Studies on Toxic Effects of BPA Couldn’t be Reproduced, says MU Research Team

By Guest PostJanuary 9, 2013Environmentagouti, agouti signaling protein, animal numbers, asip, bpa, cheryl rosenfeld, controversial chemical, dietary supplement, equal ratios, estrogenic compound, exposure, famine, fat tissue, frederick vomsaal, gene, genistein, humans, metabolic disorders, mice, obesity, obesity related disease, offspring, pancreas, plants, plastic bottles, replicate, reproduce, soy beans, thrifty genotype, type 2 diabetes, university of missouri, uterine environments, womb, yellow coat color

The MU study is not claiming that BPA is safe, but that the previous series of studies are not reproducible.

COLUMBIA, Mo. — Following a three-year study using more than 2,800 mice, a University of Missouri researcher was not able to replicate a series of previous studies by another research group investigating the controversial chemical BPA. The MU study is not claiming that BPA is safe, but that the previous series of studies are not reproducible. The MU study, published in the Proceedings of the National Academy of Sciences, also investigated an estrogenic compound found in plants, genistein, in the same three-year study.

“Our findings don’t say anything about the positive or negative effects of BPA or genistein,” said Cheryl Rosenfeld, associate professor of biomedical sciences in MU’s Bond Life Science Center. “Rather, our series of experiments did not detect the same findings as reported by another group on the potential developmental effects of BPA and genistein when exposure of young occurs in the womb.” (more…)

How Do Cells Tell Time? Scientists Develop Single-Cell Imaging to Watch the Cell Clock

By Guest PostNovember 18, 2012Science24 hour, activity, biological noise, cell, cell division, circadian clock, cyclic gene, cyclic protein, cyclical behavior, embryonic segmentation, embryonic segments, emilie delaune, gene, gene activation, life, lifespan, mesoderm, mitosis, molecular clock, muscle, nathan shih, nervous system, notch signaling pathway, oscillating pattern, oscillation, paul françois, phase, protein, sharon amacher, signal, signal reception, single cell, somites, synchronization, tissue segments, vasculature, vertebrae, visualization, visualize, zebrafish embryos

COLUMBUS, Ohio – A new way to visualize single-cell activity in living zebrafish embryos has allowed scientists to clarify how cells line up in the right place at the right time to receive signals about the next phase of their life.

Scientists developed the imaging tool in single living cells by fusing a protein defining the cells’ cyclical behavior to a yellow fluorescent protein that allows for visualization. Zebrafish embryos are already transparent, but with this closer microscopic look at the earliest stages of life, the researchers have answered two long-standing questions about how cells cooperate to form embryonic segments that later become muscle and vertebrae. (more…)

A Better Route to Xylan

By Guest PostNovember 13, 2012Sciencealex schultink, aromatic compound, atmosphere, biofuel, biofuel generation, biomass, carbon, cell wall, cellulose, cellulosic biofuel, component, coumaric acid, dawn chiniquy, dwarf phenotype, earth, extraction, ferulic, gene, glycosyltransferases, gt61 enzymes, henrik scheller, jbei, lignin, material, metric tons, pamela ronald, plant, rice, saccharification, solar energy, store, sugar, vaishali sharma, xax1, xax1 mutant, xylan, xylan chain

Joint BioEnergy Institute Researchers Find New Access to Abundant Biomass for Advanced Biofuels

After cellulose, xylan is the most abundant biomass material on Earth, and therefore represents an enormous potential source of stored solar energy for the production of advance biofuels. A major roadblock, however, has been extracting xylan from plant cell walls. Researchers with the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) have taken a significant step towards removing this roadblock by identifying a gene in rice plants whose suppression improves both the extraction of xylan and the overall release of the sugars needed to make biofuels.

The newly identified gene – dubbed XAX1 – acts to make xylan less extractable from plant cell walls. JBEI researchers, working with a mutant variety of rice plant – dubbed xax1 – in which the XAX1 gene has been “knocked-out” found that not only was xylan more extractable, but saccharification – the breakdown of carbohydrates into releasable sugars – also improved by better than 60-percent. Increased saccharification is key to more efficient production of advanced biofuels. (more…)

PTSD Consortium

By Guest PostNovember 1, 2012Healthadult, afghanistan, americans, bad experience, behavior, behavioral epigenetic, brain, brain imaging, cambridge, car accident, cardiovascular disease, chemical change, combat troops, david diamond, delaware, diagnose, disorder, DNA, dna methylation, draper laboratory, gene, hormone level, Iraq, military, molecular change, molecular modification, objective biomarker, panic attack, posttraumatic, ptsd, rate, rodent model, south florida, stress, stress disorder, tania roth, trauma, university, victim, violent crime, war

Researchers seek better ways to diagnose, treat disorder

Tania Roth studies what happens to the brain when stress occurs early in life, seeking to pinpoint how those kinds of bad experiences can cause molecular changes to DNA.

Now, by participating in a national consortium of researchers, the assistant professor of psychology at the University of Delaware is hoping to use her expertise to contribute to a better understanding of posttraumatic stress disorder (PTSD). (more…)