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Two Genetic Variations Predict Second Cancers after Radiation Treatment for Children with Hodgkin’s

By Guest PostJuly 28, 2011Health, Scienceandrew skol, apoptosis, cancer types, cells, differentiation, fundamental cellular processes, gene, genetic variations, hodgkins lymphoma, hodgkins survivors, kenan onel, nature medicine, prdm1, prmd1 gene, proliferation, radiation and chemotherapy, radiation induced second cancers, radiation therapy, sarah jackson, single nucleotide polymorphisms, timothy best, treatable cancers

A genome-wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin’s lymphoma are most likely to develop radiation-induced second cancers years after treatment. Knowing in advance who is at risk could help physicians tailor treatment to reduce the risks for patients who are most susceptible to long-term damage.

Hodgkin’s lymphoma is one of the most treatable cancers, with more than 90 percent of patients surviving after a combination of radiation and chemotherapy. But nearly 20 percent of patients treated as children develop a second cancer within 30 years. The younger the patients are when treated and the higher the radiation dose, the greater the risk. This late side effect of treatment is the second leading cause of death for long-term Hodgkin’s survivors. (more…)

For Longer-Life, Disease-Free Roses, NC State Researchers Insert Celery Gene

By Guest PostFebruary 12, 2011Sciencealcohol, botrytis, bryon sosinski, celery, Colombia, disease, ecuador, environmental factors, fungal pathogens, gene, george allen, grocery stores, john dole, john williamson, lettuce, mannitol, petal blight, plant diseases, post harvest diseases, rose, rose plants, valentine day, vase life

A rose by any other name would smell … like celery?

North Carolina State University research intended to extend the “vase life” of roses inserts a gene from celery inside rose plants to help fight off botrytis, or petal blight, one of the rose’s major post-harvest diseases.

Some fungal pathogens, the bad guys that infect plants, produce a sugar alcohol called mannitol that interferes with the plant’s ability to block disease like petal blight, which produces wilty, mushy petals – an effect similar to what happens to lettuce when it’s been in the crisper too long. (more…)

Why Coffee Protects Against Diabetes

By Guest PostJanuary 13, 2011Health, Scienceamerican diabetes association, biological activity, body, brian chen, cancer, cardiovascular disease, coffee, coffee consumption, david geffen, decaffeinated coffee, diabetes, estrogen, gene, julie buring, molecular mechanism, morning elixir, mutation, non coffee drinkers, plasma levels, protective effect, protein, sex hormone binding globulin, sex hormones, shbg, simin liu, testosterone, tolerance to insulin, type 2 diabetes

*Researchers discover molecular mechanism behind drink’s prophylactic effect*

Coffee, that morning elixir, may give us an early jump-start to the day, but numerous studies have shown that it also may be protective against type 2 diabetes. Yet no one has really understood why.

Now, researchers at UCLA have discovered a possible molecular mechanism behind coffee’s protective effect. A protein called sex hormone–binding globulin (SHBG) regulates the biological activity of the body’s sex hormones, testosterone and estrogen, which have long been thought to play a role in the development of type 2 diabetes. And coffee consumption, it turns out, increases plasma levels of SHBG. (more…)

UCLA Researchers Identify Molecular Program for Brain Repair Following Stroke

By Guest PostNovember 13, 20101 commentHealth, Scienceadult brain, atrx, axons, brain, brain stroke, carmichael, cells, DNA, drug, gene, giovanni coppola, healing process, molecular cascade, mouse, neurons, peri infarct tissue, s thomas carmichael, stroke

Mouse Stroke. An MRI of a mouse brain after stroke. The mouse section has been stained to show cell bodies. Image credit: University of California

A stroke wreaks havoc in the brain, destroying its cells and the connections between them. Depending on its severity and location, a stroke can impact someone’s life forever, affecting motor activity, speech, memories, and more.

The brain makes an attempt to rally by itself, sprouting a few new connections, called axons, that reconnect some areas of the brain. But the process is weak, and the older the brain, the poorer the repair. Still, understanding the cascade of molecular events that drive even this weak attempt could lead to developing drugs to boost and accelerate this healing process.

Now researchers at UCLA have achieved a promising first step. Reporting in the current online edition of the journal Nature Neuroscience, senior author Dr. S. Thomas Carmichael, a UCLA associate professor of neurology, and colleagues have, for the first time, identified in the mouse the molecular cascade that drives the process of reconnection or sprouting in the adult brain after stroke. (more…)

Is Breast Cancer No. 1 Killer of Women?

By PravdaJune 19, 2010Healthaids, brca1, brca2, breast cancer, cardiovascular diseases, estrogen, gene, ilona milova, la fornarina, mastectomy, menopause, olga budiakova, oncologist, pneumonia, portrait of a young woman, raffaello sanzio

The issue of breast cancer avoidance concerns many women. Opinion polls reveal that 98% of them overestimate the threat. Olga Budiakova, a breast physician, talked to “MedPulse.ru” to dispel certain myths about breast cancer.

(more…)

Good that ‘chimps’ can’t talk

By ShamsNovember 16, 2009Scienceamino-acid composition, cheetah, chimpanzee, dna code, forkhead box P2, foxp2, gene, human lineage, molecular evolution, tarzan, wolfgang enard

Of course you remember well ‘Cheeta’, Tarzan’s Chimpanzee. He amused millions of Tarzan’s fans, and remained as the closest companion of the ‘Jungle Lord’.

(more…)

Boy ohh Boy, and your ‘Warrior gene’

By ShamsJune 22, 20092 commentsSciencebiosocial, criminologist, florida state university, florida state’s college of criminology and criminal jus, gangs, gangsters, gene, Kevin m. beaver, maoa, monoamine oxidase a, variants, warrior gene, x-chromosome, y-chromosome

You read it good. The English word ‘Warrior’ is someway, all the way, related to some kind of ‘fighting’. And those who are now attributed to this ‘Warrior’ group are boys.

But who are these boys. 😉

(more…)

Tag Archives: gene

Two Genetic Variations Predict Second Cancers after Radiation Treatment for Children with Hodgkin’s

For Longer-Life, Disease-Free Roses, NC State Researchers Insert Celery Gene

Why Coffee Protects Against Diabetes

UCLA Researchers Identify Molecular Program for Brain Repair Following Stroke

Is Breast Cancer No. 1 Killer of Women?

Good that ‘chimps’ can’t talk

Boy ohh Boy, and your ‘Warrior gene’