Tag Archives: x-chromosome

Engineered Flies Spill Secret of Seizures

Scientists have observed the neurological mechanism behind temperature-dependent — febrile — seizures by genetically engineering fruit flies to harbor a mutation analogous to one that causes epileptic seizures in people. In addition to contributing the insight on epilepsy, their new study highlights the first use of genetic engineering to swap a human genetic disease mutation into a directly analogous gene in a fly.

PROVIDENCE, R.I. [Brown University] — In a newly reported set of experiments that show the value of a particularly precise but difficult genetic engineering technique, researchers at Brown University and the University of California–Irvine have created a Drosophila fruit fly model of epilepsy to discern the mechanism by which temperature-dependent seizures happen.

The researchers used a technique called homologous recombination — a more precise and sophisticated technique than transgenic gene engineering — to give flies a disease-causing mutation that is a direct analogue of the mutation that leads to febrile epileptic seizures in humans. They observed the temperature-dependent seizures in whole flies and also observed the process in their brains. What they discovered is that the mutation leads to a breakdown in the ability of certain cells that normally inhibit brain overactivity to properly regulate their electrochemical behavior. (more…)

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Evolution’s Gift May Also be at The Root of a Form of Autism

A recently evolved pattern of gene activity in the language and decision-making centers of the human brain is missing in a disorder associated with autism and learning disabilities, a new study by Yale University researchers shows.

“This is the cost of being human,” said Nenad Sestan, associate professor of neurobiology, researcher at Yale’s Kavli Institute for Neuroscience, and senior author of the paper. “The same evolutionary mechanisms that may have gifted our species with amazing cognitive abilities have also made us more susceptible to psychiatric disorders such as autism.” (more…)

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Boy ohh Boy, and your ‘Warrior gene’

You read it good. The English word ‘Warrior’ is someway, all the way, related to some kind of ‘fighting’. And those who are now attributed to this ‘Warrior’ group are boys. 

But who are these boys. 😉

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