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Genome-wide Atlas of Gene Enhancers in the Brain On-line

By Guest PostFebruary 6, 2013Scienceautism, axel visel, basal ganglia, berkeley lab, biological functions, brain on line, cerebral cortex, cerebrum, chip seq studies, chromatin immunoprecipitation, cognition, collection of data, dalit may, dna basepairs, dna elements, embryonic forebrain, emotion, epilepsy, evolution, gene, gene enhancers, gene regulating elements, gene regulatory functions, genetic mutations, genome wide atlas, gray matter, hani girgis, human brain, human diseases, junk dna, leila taher, molecular toolbox, motor functions, neurological disorders, non coding mutation, olga golonzhka, protein coding genes, schizophrenia, sequences of dna, telencephalon

Collaboration Led by Berkeley Lab Researchers Creates High-Resolution Map of Gene Regulatory Elements in the Brain

Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas, developed by a team led by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) is a publicly accessible Web-based collection of data that identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.

“Understanding how the brain develops and functions, and how it malfunctions in neurological disorders, remains one of the most daunting challenges in contemporary science,” says Axel Visel, a geneticist with Berkeley Lab’s Genomics Division. “We’ve created a genome-wide digital atlas of gene enhancers in the human brain – the switches that tell genes when and where they need to be switched on or off. This enhancer atlas will enable other scientists to study in more detail how individual genes are regulated during development of the brain, and how genetic mutations may impact human neurological disorders.” (more…)

A Bird’s Song May Teach Us About Human Speech Disorders

By Guest PostMarch 7, 2012Nature, Sciencearea x, austin hilliard, autism, basal ganglia, bat species, biostatistics, brain, cortex, disorder, dolphins, elephants, elizabeth fraley, England, flying and perching, foxp2, genes, genetic equivalent, human genetics, human stuttering, julie miller, language, male zebra finches, master gene, neuroscience, sexually mature, small bird, social network, song, songbird, speech, stephanie white, steve horvath, stroke, stuart wolpert, tissue, vocalization, zebra finch

*UCLA scientists identify 2,000 important genes*

Can the song of a small bird provide valuable insights into human stuttering and speech-related disorders and conditions, including autism and stroke? New research by UCLA life scientists and colleagues provides reason for optimism.

The scientists discovered that some 2,000 genes in a region of the male zebra finch’s brain known as “Area X” are significantly linked to singing. More than 1,500 genes in this region, a critical part of the bird’s song circuitry, are being reported for the first time. Previously, a group of scientists including the UCLA team had identified some 400 genes in Area X. All the genes’ levels of expression change when the bird sings. (more…)

New Study to Test Unusual Hypothesis on Beta Brainwaves

By Guest PostDecember 4, 2011Sciencebasal ganglia, beta, beta brainwaves, beta oscillations, brown university, christopher moore, cortex, david orenstein, hypothesis, key brain circuit, model, moore and jones, neurons, neuroscientists, optogenetics, parkinsonian symptoms, parkinsons disease, physical brain, predictions, sensory information, somatosensory system, stephanie jones, thalamocortical circuit, thalamus, touch, touch perception circuit

Beta oscillations are tightly linked to Parkinson’s disease and the ability to process sensory information, such as touch. Two neuroscientists have brought their collaboration to Brown University and won funding from the National Science Foundation to see if they can finally provide a definitive, if unorthodox, explanation for beta brainwaves.

Before she could seek to convince the world that her computer model of a key brain circuit explains a fundamental, 80-year-old mystery of neuroscience with potential relevance to Parkinson’s disease, Stephanie Jones sought to convince Christopher Moore. The new Brown neuroscience professors are now close collaborators, but when they first started talking about the beta oscillations of the cortex, Moore thought Jones was plain wrong, if not a bit nuts. (more…)

Brain Imaging Technique: New Hope for Understanding Parkinson’s Disease

By Guest PostMarch 2, 2011Health, Sciencebasal ganglia, biomedical engineering, brain imaging technique, brain oscillations, disease progression, l dopa, medication, mri, neural oscillations, neurology, parkinsons disease, patients, placebo pill, rachael seidler, radiology, ripple in the pond, scott peltier, symptoms, treatment, youngbin kwak

ANN ARBOR, Mich.— A non-invasive brain imaging technique gives new hope to patients with Parkinson’s disease in finding new and better treatment plans and tracking the disease progression, a new University of Michigan study shows.

The technique uses an MRI to measure resting state brain activity oscillations, said Rachael Seidler, associate professor in the School of Kinesiology and the Department of Psychology, and study author. (more…)

Tag Archives: basal ganglia

Genome-wide Atlas of Gene Enhancers in the Brain On-line

A Bird’s Song May Teach Us About Human Speech Disorders

New Study to Test Unusual Hypothesis on Beta Brainwaves

Brain Imaging Technique: New Hope for Understanding Parkinson’s Disease