Tag Archives: epilepsy

A way to bring peace of mind — and sleep — to parents whose children suffer seizures wins Microsoft Hackathon

For most parents, sleep is a sacrifice they accept during the earliest part of their child’s life. But for Francesca Fedeli and Roberto D’Angelo, sleep deprivation has been a constant for five years as they’ve taken turns in overnight co-sleeping vigils for their 8-year-old son, Mario, who has suffered potentially life-threatening seizures since he was 3. (more…)

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New technique could revolutionise surgical treatment of epilepsy

Scientists at the University of Exeter have developed a pioneering new technique that could revolutionise the surgical treatment of epilepsy.

The team of scientists, led by Dr Marc Goodfellow and Professor John Terry, have developed the ground-breaking new method that can identify the specific regions of the brain that trigger seizures in people with epilepsy.

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Why we embrace the ritual of Valentine’s Day: Q&A with a Yale sociologist

Whether you’re a die-hard romantic or a callous cynic, there’s no escaping the millions of couples cozying up this Feb. 14 to celebrate Valentine’s Day.  

The origins of our only holiday devoted to love are somewhat murky. It is thought to have its beginnings in the Roman festival of Lupercalia, which was celebrated in mid-February. The fertility ritual included animal sacrifice, nude men, women flogged with animal hides, and a matchmaking lottery akin to a 1970s key party. (more…)

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UCLA to develop ‘brain prosthesis’ to help brain-injured patients recover memory

As part of a major federal initiative, UCLA has been awarded $15M to create a wireless, implantable device that could restore memory to millions

UCLA has been tapped by the Defense Advanced Research Projects Agency to spearhead an innovative project aimed at developing a wireless, implantable brain device that could help restore lost memory function in individuals who have suffered debilitating brain injuries and other disorders. (more…)

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UA Geneticists Find Causes for Severe Childhood Epilepsies

Using a state-of-the-art DNA sequencing technique, UA researchers have discovered genetic mutations underlying seizure disorders in previously undiagnosed children.

Researchers at the University of Arizona have successfully determined the genetic mutations causing severe epilepsies in seven out of 10 children for whom the cause of the disorder could not be determined clinically or by conventional genetic testing.

Instead of sequencing each gene one at a time, the team used a technique called whole-exome sequencing: Rather than combing through all of the roughly 3 billion base pairs of an individual’s entire genome, whole-exome-sequencing deciphers only actual genes, and nearly all of them simultaneously. (more…)

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Misregulated genes may have big autism role

A genetic pathway involving proteins in the endosomes of cells appears to be misregulated in the brains of children with autism, according to a newly published statistical analysis in the journal Molecular Psychiatry. Previously the genes were shown to cause rare forms of the disease but the new study suggests they have a wider role.

PROVIDENCE, R.I. [Brown University] — A new study finds that two genes individually associated with rare autism-related disorders are also jointly linked to more general forms of autism. The finding suggests a new genetic pathway to investigate in general autism research. (more…)

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Peer support shows promise in epilepsy fight

Peer support groups show promise for combating the debilitating stigma that surrounds epilepsy in much of the developing world, according to a new study led by a Michigan State University medical student.

The researchers report in the journal Epilepsy and Behavior that young people with the disease felt significantly less stigmatized after meeting regularly to discuss their illness. (more…)

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Genome-wide Atlas of Gene Enhancers in the Brain On-line

Collaboration Led by Berkeley Lab Researchers Creates High-Resolution Map of Gene Regulatory Elements in the Brain

Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas, developed by a team led by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) is a publicly accessible Web-based collection of data that identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.

“Understanding how the brain develops and functions, and how it malfunctions in neurological disorders, remains one of the most daunting challenges in contemporary science,” says Axel Visel, a geneticist with Berkeley Lab’s Genomics Division. “We’ve created a genome-wide digital atlas of gene enhancers in the human brain – the switches that tell genes when and where they need to be switched on or off. This enhancer atlas will enable other scientists to study in more detail how individual genes are regulated during development of the brain, and how genetic mutations may impact human neurological disorders.” (more…)

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