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Genome-wide Atlas of Gene Enhancers in the Brain On-line

By Guest PostFebruary 6, 2013Scienceautism, axel visel, basal ganglia, berkeley lab, biological functions, brain on line, cerebral cortex, cerebrum, chip seq studies, chromatin immunoprecipitation, cognition, collection of data, dalit may, dna basepairs, dna elements, embryonic forebrain, emotion, epilepsy, evolution, gene, gene enhancers, gene regulating elements, gene regulatory functions, genetic mutations, genome wide atlas, gray matter, hani girgis, human brain, human diseases, junk dna, leila taher, molecular toolbox, motor functions, neurological disorders, non coding mutation, olga golonzhka, protein coding genes, schizophrenia, sequences of dna, telencephalon

Collaboration Led by Berkeley Lab Researchers Creates High-Resolution Map of Gene Regulatory Elements in the Brain

Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas, developed by a team led by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) is a publicly accessible Web-based collection of data that identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.

“Understanding how the brain develops and functions, and how it malfunctions in neurological disorders, remains one of the most daunting challenges in contemporary science,” says Axel Visel, a geneticist with Berkeley Lab’s Genomics Division. “We’ve created a genome-wide digital atlas of gene enhancers in the human brain – the switches that tell genes when and where they need to be switched on or off. This enhancer atlas will enable other scientists to study in more detail how individual genes are regulated during development of the brain, and how genetic mutations may impact human neurological disorders.” (more…)

One Tiny Electron Could be Key to Future Drugs That Repair Sunburn

By Guest PostJuly 30, 2011Scienceatoms in the dna molecule, aziz sancar, biological functions, cancer, cells of plants, chuang tan, cyclobutane pyrimidine dimer, cyclobutane ring, damaged dna, dongping zhong, electron, enzyme, enzyme photolyase, genetic mutations, key biological molecules, ohio state, ohio state university, proteins, repair of sunburn, source of energy, sun damaged dna, ultraviolet light, zheyun liu

COLUMBUS, Ohio – Researchers who have been working for nearly a decade to piece together the process by which an enzyme repairs sun-damaged DNA have finally witnessed the entire process in full detail in the laboratory.

What they saw contradicts fundamental notions of how key biological molecules break up during the repair of sunburn – and that knowledge could someday lead to drugs or even lotions that could heal sunburn in humans. (more…)

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Genome-wide Atlas of Gene Enhancers in the Brain On-line

One Tiny Electron Could be Key to Future Drugs That Repair Sunburn