Tag Archives: berkeley lab

Berkeley Lab Scientists Develop New Tool for the Study of Spatial Patterns in Living Cells

By Guest PostNovember 2, 2011Scienceartificial membranes, berkeley lab, biology is a game of nanometers, breast cancer cells, cancer and the immune system, cancer metastasis, cellular molecules, chemical signals, chemist, fluid bilayer of lipid molecules, football, game of inches, geoff o donoghue, gold nanoparticles, golden membranes, hhmi, howard hughes medical institute, impact of spatial patterns on living cells, jay groves, lawrence berkeley national laboratory, mda mb 231, michael coyle, nanoparticles, natural lipid bilayer membranes, qian xu, sara triffo, spacing of proteins, substrate of solid silica, t cell immunology, theobald lohmuller

*Golden Membranes Pave the Way for a Better Understanding of Cancer and the Immune System*

Football has often been called “a game of inches,” but biology is a game of nanometers, where spatial differences of only a few nanometers can determine the fate of a cell – whether it lives or dies, remains normal or turns cancerous. Scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a new and better way to study the impact of spatial patterns on living cells.

Berkeley Lab chemist Jay Groves led a study in which artificial membranes made up of a fluid bilayer of lipid molecules were embedded with fixed arrays of gold nanoparticles to control the spacing of proteins and other cellular molecules placed on the membranes. This provided the researchers with an unprecedented opportunity to study how the spatial patterns of chemical and physical properties on membrane surfaces influence the behavior of cells. (more…)

Shaken, not Stirred: Berkeley Lab Scientists Spy Molecular Maneuvers

By Guest PostOctober 24, 2011Scienceandrew cho, atomic precision, babak sanii, berkeley lab, biomimetic materials, catalyze a reaction, development of peptoids, gloria olivier, james bond, langmuir blodgett trough, lawrence berkeley national laboratory, liquid, membrane for filtration, misfolded proteins, molecules, nanomaterials, nanoscale ropes, nanosheet, neeraja venkateswaran, peptoid nanosheets, peptoids, protein like structures, romas kudirka, ron zuckermann, shake, synthetic polymers, two dimensional nanomaterials

Stir this clear liquid in a glass vial and nothing happens. Shake this liquid, and free-floating sheets of protein-like structures emerge, ready to detect molecules or catalyze a reaction. This isn’t the latest gadget from James Bond’s arsenal—rather, the latest research from the U. S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) scientists unveiling how slim sheets of protein-like structures self-assemble. This “shaken, not stirred” mechanism provides a way to scale up production of these two-dimensional nanosheets for a wide range of applications, such as platforms for sensing, filtration and templating growth of other nanostructures.

“Our findings tell us how to engineer two-dimensional, biomimetic materials with atomic precision in water,” said Ron Zuckermann, Director of the Biological Nanostructures Facility at the Molecular Foundry, a DOE nanoscience user facility at Berkeley Lab. “What’s more, we can produce these materials for specific applications, such as a platform for sensing molecules or a membrane for filtration.” (more…)

Close Up Look at a Microbial Vaccination Program

By Guest PostOctober 3, 2011Health, Sciencebacterium, berkeley lab, blake wiedenheft, casa, casb, case, cells, clustered regularly interspaced short palindromic repea, complex of proteins, crispr, cryo electron microscopy, e coli, escherichia coli, eva nogales, gabriel lander, human pathogens, immune system, infections by bacteria, invading pathogens, jennifer doudna, john van der oost, kaihong zhou, microbe, microbial, microbial immune systems, microbiome, perturbations, protein complex called cascade, seahorse, short interfering rnas, sirnas, symbioses, toxins, unit of dna, viruses

*Berkeley Lab Researchers Resolve Sub-nanometer Structure of Cascade, an Ally for Human Immune System*

A complex of proteins in the bacterium E.coli that plays a critical role in defending the microbe from viruses and other invaders has been discovered to have the shape of a seahorse by researchers with the U.S Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). This discovery holds far more implications for your own health than you might think.

In its never-ending battle to protect you from infections by bacteria, viruses, toxins and other invasive elements, your immune system has an important ally – many allies in fact. By the time you reach adulthood, some 90-percent of the cells in your body are microbial. These microbes – collectively known as the microbiome – play a critical role in preserving the health of their human host. (more…)

Get the Light, Beat the Heat

By Guest PostSeptember 11, 2011Scienceandre anders, anna llordes, berkeley lab, breakthrough technology, carbon emissions in the united states, coloration efficiency, delia milliron, department of energy, doe, dynamic window coatings, electric charge, electrochromic materials, evan runnerstrom, guillermo garcia, lawrence berkeley national laboratory, near infrared frequency range, raffaella buonsanti, rueben mendelsberg, semiconductor nanocrystal coating material, semiconductor nanocrystals, smart window, thomas richardson

*Berkeley Lab Researchers Develop New Infrared Coating for Windows*

Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have unveiled a semiconductor nanocrystal coating material capable of controlling heat from the sun while remaining transparent. Based on electrochromic materials, which use a jolt of electric charge to tint a clear window, this breakthrough technology is the first to selectively control the amount of near infrared radiation. This radiation, which leads to heating, passes through the film without affecting its visible transmittance. Such a dynamic system could add a critical energy-saving dimension to “smart window” coatings. (more…)

The Brittleness of Aging Bones – More than a Loss of Bone Mass

By Guest PostSeptember 3, 2011Scienceadvanced light source, age related structural changes in human cortical bone, als, berkeley lab, biological aging, björn busse, bone strength and fracture toughness, bones, brittle, calcium, collagen molecules, concentric rings of lamellae plates, department of energy, doe, elizabeth zimmermann, eric schaible, fracturing, ha, holly barth, hrishikesh bale, human cortical or compact bone, hydroxyapatite, joel ager, lawrence berkeley national laboratory, loss of mass, macroscopic fracture testing, molecular level, nanocrystals, nanoscale, older bones fracturing, peter reichert, robert ritchie, simon tang, tamara alliston, uc, university of california, young human bone

*Berkeley Lab Researchers Show How Loss of Bone Quality Also a Major Factor*

It is a well-established fact that as we grow older our bones become more brittle and prone to fracturing. It is also well established that loss of mass is a major reason for older bones fracturing more readily than younger bones, hence medical treatments have focused on slowing down this loss. However, new research from scientists at the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) shows that at microscopic dimensions, the age-related loss of bone quality can be every bit as important as the loss of quantity in the susceptibility of bone to fracturing. (more…)

Thawing Permafrost Could Release Vast Amounts of Carbon and Accelerate Climate Change by the end of this Century

By Guest PostAugust 27, 2011Environmentalternative energies and atomic energy commission, amount of soil carbon, atmosphere, berkeley lab, boreal and arctic land ecosystems, canada, carbon, carbon dioxide, charles koven, climate changes, combine, computer modeling, energy, European Union, france, frozen soils, global warming, high latitude permafrost, intergovernmental panel on climate change, land surface ecosystem model, lawrence berkeley national laboratory, methane emissions, orchidee, organic matter, plant growth, project, rate of soil carbon decomposition, simulation, supercomputing facility, temperature, united kingdom

*New computer modeling study, led by a Berkeley Lab scientist, could help revise understanding of permafrost’s role in global warming*

Billions of tons of carbon trapped in high-latitude permafrost may be released into the atmosphere by the end of this century as the Earth’s climate changes, further accelerating global warming, a new computer modeling study indicates.

The study also found that soil in high-latitude regions could shift from being a sink to a source of carbon dioxide by the end of the 21^st century as the soil warms in response to climate change. (more…)

First Data from Daya Bay: Closing in on a Neutrino Mystery

By Guest PostAugust 16, 2011Scienceantineutrinos, basic physics, berkeley lab, big bang, China, china guangdong nuclear power group, cosmic rays, daya bay reactor neutrino experiment, dubbed θ13, electron, evolution of basic kinds of matter, flavors of neutrinos, hong kong, kam biu luk, lawrence berkeley national laboratory, liquid scintillator, mixing angles, muon, neutrinos, nuclear reactors, photomultiplier tubes, russia, southern china, taiwan, tau neutrinos, the czech republic, theta one three, united states, william edwards

*Berkeley Lab researchers are leaders in an international effort to close in on neutrino mass*

Some of the most intriguing questions in basic physics focus on neutrinos. How much do the different kinds weigh and which is the heaviest? The answers lie in how the three “flavors” of neutrinos – electron, muon, and tau neutrinos – oscillate or mix, changing from one to another as they race virtually without interruption through unbounded reaches of matter and space.

Three mathematical terms known as “mixing angles” described the process, and the Daya Bay Reactor Neutrino Experiment has just begun taking data to establish the last, least-known mixing angle to unprecedented precision. China and the United States lead the international Daya Bay Collaboration, including participants from Russia, the Czech Republic, Hong Kong, and Taiwan. U.S. participation is led by the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). (more…)

Berkeley Scientists Pioneer Nanoscale Nuclear Materials Testing Capability

By Guest PostJuly 2, 2011Environment, Scienceandrew minor, berkeley lab, clean energy future, compression tests of copper specimens, crystal structure, daniel kiener, dislocations, electricity, emission free sources, fukushima disaster, irradiated materials, Japan, lifetime of a nuclear reactor, macroscale materials strength properties, medical industry, nanoscale testing technique, national center for electron microscopy, ncem, nuclear materials, nuclear plants, nuclear power, operation and safety, peter hosemann, power generation, production of radioisotopes, renewable, safer nuclear technologies, stress tests, stuart maloy, sub nanoscale resolution, Technology, united states

Nuclear power is a major component of our nation’s long-term clean-energy future, but the technology has come under increased scrutiny in the wake of Japan’s recent Fukushima disaster. Indeed, many nations have called for checks and “stress tests” to ensure nuclear plants are operating safely.

In the United States, about 20 percent of our electricity and almost 70 percent of the electricity from emission-free sources, including renewable technologies and hydroelectric power plants, is supplied by nuclear power. Along with power generation, many of the world’s nuclear facilities are used for research, materials testing, or the production of radioisotopes for the medical industry. The service life of structural and functional material components in these facilities is therefore crucial for ensuring reliable operation and safety. (more…)