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Testing Artificial Photosynthesis

By Guest PostJuly 3, 2013Scienceanode, artificial photosynthesis, atmospheric carbon dioxide, berkeley lab, caltech, camilo diaz botia, cathode, charge carriers, diesel, earth abundant elements, energy conversion, fossil fuel energy, gasoline, h2, hydrocarbon, hydrogen, jcap, jcap north, jcap south, joel ager, mean concentration, membrane cap, micro scale, microfluidic test bed, miguel modestino, o2, optimization, rachel segalman, rafael gomez sjoberg, sophia haussener

Berkeley Lab Researchers Develop Fully Integrated Microfluidic Test-bed for Solar-driven Electrochemical Energy Conversion Systems

With the daily mean concentrations of atmospheric carbon dioxide having reached 400 parts-per-million for the first time in human history, the need for carbon-neutral alternatives to fossil fuel energy has never been more compelling. With enough energy in one hour’s worth of global sunlight to meet all human needs for a year, solar technologies are an ideal solution. However, a major challenge is to develop efficient ways to convert solar energy into electrochemical energy on a massive-scale. A key to meeting this challenge may lie in the ability to test such energy conversion schemes on the micro-scale.

Berkeley Lab researchers, working at the Joint Center for Artificial Photosynthesis (JCAP), have developed the first fully integrated microfluidic test-bed for evaluating and optimizing solar-driven electrochemical energy conversion systems. This test-bed system has already been used to study schemes for photovoltaic electrolysis of water, and can be readily adapted to study proposed artificial photosynthesis and fuel cell technologies. (more…)

Molecular Spectroscopy Tracks Living Mammalian Cells in Real Time as They Differentiate

By Guest PostMay 2, 2012Scienceals, alzheimer's disease, amino acid residues, apoptosis, bacteria, berkeley lab, carbohydrates, cell change, cell death, children, diabetes, fibroblasts, fluorescent dyes, fourier transform infrared, ftir, function, hans bechtel, hoi ying, hyperspectromicroscopy, ir, kevin loutherback, liang chen, lipids, macular degeneration, michael martin, mitochondrial diseases, pc12, phosphorylation, phosphorylation process, power plant, protein, rafael gomez sjoberg, retina, san diego, serine, spectromicroscopy, threonine, tyrosine, ultraviolet, university of california, zhao hao

Berkeley Lab scientists demonstrate the promise of synchrotron infrared spectroscopy of living cells for medical applications

Knowing how a living cell works means knowing how the chemistry inside the cell changes as the functions of the cell change. Protein phosphorylation, for example, controls everything from cell proliferation to differentiation to metabolism to signaling, and even programmed cell death (apoptosis), in cells from bacteria to humans. It’s a chemical process that has long been intensively studied, not least in hopes of treating or eliminating a wide range of diseases. But until now the close-up view – watching phosphorylation work at the molecular level as individual cells change over time – has been impossible without damaging the cells or interfering with the very processes that are being examined.

“To look into phosphorylation, researchers have labeled specific phosphorylated proteins with antibodies that carry fluorescent dyes,” says Hoi-Ying Holman of the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). “That gives you a great image, but you have to know exactly what to label before you can even begin.” (more…)

New Take on Impacts of Low Dose Radiation

By Guest PostDecember 24, 2011Health, Scienceatomic bomb blasts, berkeley lab, biological damage, breast cell line, broken dna, cancer risks, christopher pham, dna damage response, dna repair mechanisms, Environment, epidemiological data, extrapolation, gy of radiation, human breast cells, human tissue, ionizing radiation, Japan, joel swenson, lawrence berkeley national laboratory, levels of ionizing radiation, linear no threshold hypothesis, lnt, low dose radiation, mammogram, mathematical modeling, mcf10a, mina bissell, primary breast epithelial cells, radiation induced foci, rafael gomez sjoberg, repair, rif, standard model, survivors, sylvain costes, teresa neumaier, time lapse imaging, world war II, xray microbeam

*Berkeley Lab Researchers Find Evidence Suggesting Risk May Not Be Proportional to Dose at Low Dose Levels*

Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab), through a combination of time-lapse live imaging and mathematical modeling of a special line of human breast cells, have found evidence to suggest that for low dose levels of ionizing radiation, cancer risks may not be directly proportional to dose. This contradicts the standard model for predicting biological damage from ionizing radiation – the linear-no-threshold hypothesis or LNT – which holds that risk is directly proportional to dose at all levels of irradiation.

“Our data show that at lower doses of ionizing radiation, DNA repair mechanisms work much better than at higher doses,” says Mina Bissell, a world-renowned breast cancer researcher with Berkeley Lab’s Life Sciences Division. “This non-linear DNA damage response casts doubt on the general assumption that any amount of ionizing radiation is harmful and additive.” (more…)

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Testing Artificial Photosynthesis

Molecular Spectroscopy Tracks Living Mammalian Cells in Real Time as They Differentiate

New Take on Impacts of Low Dose Radiation