Berkeley Lab Facility Provides Unique Capabilities for the Synthesis of New Crystals and Materials
Talk with material scientist Edith Bourret-Courchesne about what it takes to grow and develop useful crystals and a word you will hear repeated often is “patience.” As the leader of a unique crystal growth facility at Lawrence Berkeley National Laboratory (Berkeley Lab) dedicated to the synthesis of crystals and new materials, patience is more than a virtue, it’s a necessity.
“The growth of every crystal is unique, like the formation of a snowflake, and since we work with compounds that have never before been crystallized the processes by which we grow our crystals are also unique,” she says. “As a result, a lot of our research is aimed at understanding why something didn’t work.” (more…)
One of the world’s first working circular particle accelerators returns to Berkeley Lab—75 years later.
Seventy-five years after one of the world’s first working cyclotrons was handed to the London Science Museum, it has returned to its birthplace in the Berkeley hills, where the man who invented it, Ernest O. Lawrence, helped launch the field of modern particle physics as well as the national laboratory that would bear his name, Lawrence Berkeley National Laboratory.
On Jan. 9, 1932 the brass cyclotron—which measures 26 inches from end to end and whose accelerating chamber measures just 11 inches in diameter—was successfully used to boost protons to energies of 1.22 million electron volts. Its return to Berkeley Lab caps a decades-long saga in which various parties endeavored to secure the cyclotron’s return from London, but the persistence of Pamela Patterson, who chronicles Berkeley Lab’s history as managing editor of its website, finally paid off. (more…)
Berkeley Lab and SLAC Researchers Demonstrate Room Temperature Simultaneous Diffraction/Spectroscopy of Metalloenzymes
From providing living cells with energy, to nitrogen fixation, to the splitting of water molecules, the catalytic activities of metalloenzymes – proteins that contain a metal ion – are vital to life on Earth. A better understanding of the chemistry behind these catalytic activities could pave the way for exciting new technologies, most prominently artificial photosynthesis systems that would provide clean, green and renewable energy. Now, researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the SLAC National Accelerator Laboratory have taken a major step towards achieving this goal.
Using ultrafast, intensely bright pulses of X-rays from SLAC’s Linac Coherent Light Source (LCLS), the world’s most powerful X-ray laser, the researchers were able to simultaneously image at room temperature the atomic and electronic structures of photosystem II, a metalloenzyme critical to photosynthesis. (more…)
Scientists from Berkeley Lab and the Max Planck Institute for Terrestrial Microbiology analyze a unique microbial motor
The protein structure of the motor that propels archaea has been characterized for the first time by a team of scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and Germany’s Max Planck Institute (MPI) for Terrestrial Microbiology.
The motility structure of this third domain of life has long been called a flagellum, a whip-like filament that, like the well-studied bacterial flagellum, rotates like a propeller. But although the archaeal structure has a similar function, it is so profoundly different in structure, genetics, and evolution that the researchers argue it deserves its own name: archaellum. (more…)
Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.
“The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer,” says chemist Jay Groves, one of the leaders of this research. “Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we’ve determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand.” (more…)
Collaboration Led by Berkeley Lab Researchers Creates High-Resolution Map of Gene Regulatory Elements in the Brain
Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas, developed by a team led by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) is a publicly accessible Web-based collection of data that identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.
“Understanding how the brain develops and functions, and how it malfunctions in neurological disorders, remains one of the most daunting challenges in contemporary science,” says Axel Visel, a geneticist with Berkeley Lab’s Genomics Division. “We’ve created a genome-wide digital atlas of gene enhancers in the human brain – the switches that tell genes when and where they need to be switched on or off. This enhancer atlas will enable other scientists to study in more detail how individual genes are regulated during development of the brain, and how genetic mutations may impact human neurological disorders.” (more…)
Berkeley Lab scientists devise new tools for detecting previously unknown tree mortality.
The Earth’s forests perform a well-known service to the planet, absorbing a great deal of the carbon dioxide pollution emitted into the atmosphere from human activities. But when trees are killed by natural disturbances, such as fire, drought or wind, their decay also releases carbon back into the atmosphere, making it critical to quantify tree mortality in order to understand the role of forests in the global climate system. Tropical old-growth forests may play a large role in this absorption service, yet tree mortality patterns for these forests are not well understood.
Now scientist Jeffrey Chambers and colleagues at the U.S. Department of Energy’s (DOE) Lawrence Berkeley National Laboratory (Berkeley Lab) have devised an analytical method that combines satellite images, simulation modeling and painstaking fieldwork to help researchers detect forest mortality patterns and trends. This new tool will enhance understanding of the role of forests in carbon sequestration and the impact of climate change on such disturbances. (more…)
Berkeley Lab scientists join an international collaboration to understand how archaea and bacteria work together deep in a cold sulfur spring
In the fall of 2010, Hoi-Ying Holman of the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) was approached by an international team researching a mysterious microbial community discovered deep in cold sulfur springs in southern Germany.
“They told me what they were doing and said, ‘We know what you contributed to the oil-spill research,’” recalls Holman, who heads the Chemical Ecology group in Berkeley Lab’s Earth Sciences Division. “They wondered if I could help them determine the biochemistry of their microbe samples.” (more…)
