Tag Archives: berkeley lab

Flawed Diamonds Promise Sensory Perfection

Berkeley Lab researchers and their colleagues extend electron spin in diamond for incredibly tiny magnetic detectors

From brain to heart to stomach, the bodies of humans and animals generate weak magnetic fields that a supersensitive detector could use to pinpoint illnesses, trace drugs – and maybe even read minds. Sensors no bigger than a thumbnail could map gas deposits underground, analyze chemicals, and pinpoint explosives that hide from other probes.

Now scientists at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley, working with colleagues from Harvard University, have improved the performance of one of the most potent possible sensors of magnetic fields on the nanoscale – a diamond defect no bigger than a pair of atoms, called a nitrogen vacancy (NV) center. (more…)

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Comparing Proteins at a Glance

Berkeley Lab Researchers Unveil Technique for Easy Comparisons of Proteins in Solution

A revolutionary X-ray analytical technique that enables researchers at a glance to identify structural similarities and differences between multiple proteins under a variety of conditions has been developed by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). As a demonstration, the researchers used this technique to gain valuable new insight into a protein that is a prime target for cancer chemotherapy.

“Proteins and other biological macromolecules are moving machines whose power is often derived from how their structural conformations change in response to their environment,” says Greg Hura, a scientist with Berkeley Lab’s Physical Biosciences Division. “Knowing what makes a protein change has incredible value, much like knowing that stepping on a gas pedal makes the wheels of a car spin.” (more…)

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Bold Move Forward in Molecular Analyses

Berkeley Lab Researchers Develop New Metrics for X-ray and Neutron Analysis of Flexible Macromolecules

A dramatic leap forward in the ability of scientists to study the structural states of macromolecules such as proteins and nanoparticles in solution has been achieved by a pair of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). The researchers have developed a new set of metrics for analyzing data acquired via small angle scattering (SAS) experiments with X-rays (SAXS) or neutrons (SANS). Among other advantages, this will reduce the time required to collect data by up to 20 times.

“SAS is the only technique that provides a complete snapshot of the thermodynamic state of macromolecules in a single image,” says Robert Rambo, a scientist with Berkeley Lab’s Physical Biosciences Division, who developed the new SAS metrics along with John Tainer of Berkeley Lab’s Life Sciences Division and the Scripps Research Institute. (more…)

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Berkeley Lab Startup Brings Fuel Cells to the Developing World

Point Source Power’s cheap, rugged fuel cells can provide electricity where none exists.

In some parts of the developing world, people may live in homes without electricity or toilets or running water but yet they own cell phones. To charge those phones, they may have to walk for miles to reach a town charging station—and possibly even have to leave their phones overnight. Now a startup company spun off technology developed at Lawrence Berkeley National Laboratory (Berkeley Lab) has created a simple, inexpensive way to provide electricity to the 2.5 billion people in the world who don’t get it reliably.

Point Source Power’s innovative device is based on a solid oxide fuel cell that is powered by burning charcoal, wood or other types of biomass—even cow dung—the types of fuel that many in the developing world use for cooking. The fuel cell sits in the fire and is attached to circuitry in a handle that is charged as the fuel cell heats up to temperatures of 700 to 800 degrees Celsius. The handle, which contains an LED bulb, can then be detached and used for lighting or to charge a phone. (more…)

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Hidden Dangers in the Air We Breathe

Berkeley Lab researchers work on new building standards after discovering previously unknown indoor air pollutants.

For decades, no one worried much about the air quality inside people’s homes unless there was secondhand smoke or radon present. Then scientists at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) made the discovery that the aggregate health consequences of poor indoor air quality are as significant as those from all traffic accidents or infectious diseases in the United States. One major source of indoor pollutants in the home is cooking.

The Berkeley Lab scientists are now working on turning those research findings into science-based solutions, including better standards for residential buildings and easier ways to test for the hazardous pollutants. These efforts are the result of a paper published in Environmental Health Perspectives in 2012 that described a new method for estimating the chronic health impact of indoor air pollutants. That research uncovered two pollutants that previously had not been recognized as a cause for concern—fine particles and a gas called acrolein. (more…)

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Sweet Success: Berkeley Lab Researchers Find Way to Catalyze More Sugars from Biomass

Catalysis may initiate almost all modern industrial manufacturing processes, but catalytic activity on solid surfaces is poorly understood. This is especially true for the cellulase enzymes used to release fermentable sugars from cellulosic biomass for the production of advanced biofuels. Now, researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) through support from the Energy Biosciences Institute (EBI) have literally shed new light on cellulase  catalysis.

Using an ultrahigh-precision visible light microscopy technique called PALM – for Photo-Activated Localization Microscopy – the researchers have found a way to improve the collective catalytic activity of enzyme cocktails that can boost the yields of sugars for making fuels. Increasing the sugar yields from cellulosic biomass to help bring down biofuel production costs is essential for the widespread commercial adoption of these fuels. (more…)

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Making Do with More: Joint BioEnergy Institute Researchers Engineer Plant Cell Walls to Boost Sugar Yields for Biofuels

When blessed with a resource in overwhelming abundance it’s generally a good idea to make valuable use of that resource. Lignocellulosic biomass is the most abundant organic material on Earth. For thousands of years it has been used as animal feed, and for the past two centuries has been a staple of the paper industry. This abundant resource, however, could also supply the sugars needed to produce advanced biofuels that can supplement or replace fossil fuels, providing several key technical challenges are met. One of these challenges is finding ways to more cost-effectively extract those sugars. Major steps towards achieving this breakthrough are being taken by researchers at the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI).

“Through the tools of synthetic biology, we have engineered healthy plants whose lignocellulosic biomass can more easily be broken down into simple sugars for biofuels,” says Dominique Loque, who directs the cell wall engineering program for JBEI’s Feedstocks Division. “Working with the model plant, Arabidopsis, as a demonstration tool, we have genetically manipulated secondary cell walls to reduce the production of lignin while increasing the yield of fuel sugars.” (more…)

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Berkeley Lab Researchers Use Metamaterials to Observe Giant Photonic Spin Hall Effect

Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have once again demonstrated the incredible capabilities of metamaterials – artificial nanoconstructs whose optical properties arise from their physical structure rather than their chemical composition. Engineering a unique two-dimensional sheet of gold nanoantennas, the researchers were able to obtain the strongest signal yet of the photonic spin Hall effect, an optical phenomenon of quantum mechanics that could play a prominent role in the future of computing.

“With metamaterial, we were able to greatly enhance a naturally weak effect to the point where it was directly observable with simple detection techniques,” said Xiang Zhang,  a faculty scientist with Berkeley Lab’s Materials Sciences Division who led this research. “We also demonstrated that metamaterials not only allow us to control the propagation of light but also allows control of circular polarization. This could have profound consequences for information encoding and processing.” (more…)

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