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Comparing Proteins at a Glance

By Guest PostMay 23, 2013Scienceatp hydrolysis, berkeley lab, big puzzle, cancer chemotherapy, car spin, comparing proteins, cynthia mcmurray, en masse, function follows form, glance, greg hura, helen budworth, imaging technique, kevin dyer, macromolecules, michal hammel, multiple proteins, mutation, problematic dna, protein structures, robert rambo, saxs, xray analytical technique

Berkeley Lab Researchers Unveil Technique for Easy Comparisons of Proteins in Solution

A revolutionary X-ray analytical technique that enables researchers at a glance to identify structural similarities and differences between multiple proteins under a variety of conditions has been developed by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). As a demonstration, the researchers used this technique to gain valuable new insight into a protein that is a prime target for cancer chemotherapy.

“Proteins and other biological macromolecules are moving machines whose power is often derived from how their structural conformations change in response to their environment,” says Greg Hura, a scientist with Berkeley Lab’s Physical Biosciences Division. “Knowing what makes a protein change has incredible value, much like knowing that stepping on a gas pedal makes the wheels of a car spin.” (more…)

Bold Move Forward in Molecular Analyses

By Guest PostMay 21, 2013Scienceabsolute scale, berkeley lab, cell biology, concentration, control, data collection, dataset, john tainer, macromolecules, molecular analyses, molecular machines, nanoparticle, neutrons, protein, robert rambo, sans, sas, sas analysis, sas based statistic, saxs, small angle scattering, solution, structural state, volume of correlation

Berkeley Lab Researchers Develop New Metrics for X-ray and Neutron Analysis of Flexible Macromolecules

A dramatic leap forward in the ability of scientists to study the structural states of macromolecules such as proteins and nanoparticles in solution has been achieved by a pair of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). The researchers have developed a new set of metrics for analyzing data acquired via small angle scattering (SAS) experiments with X-rays (SAXS) or neutrons (SANS). Among other advantages, this will reduce the time required to collect data by up to 20 times.

“SAS is the only technique that provides a complete snapshot of the thermodynamic state of macromolecules in a single image,” says Robert Rambo, a scientist with Berkeley Lab’s Physical Biosciences Division, who developed the new SAS metrics along with John Tainer of Berkeley Lab’s Life Sciences Division and the Scripps Research Institute. (more…)

Carbon from Martian Meteorites Not Evidence of Life

By Guest PostMay 25, 2012Sciencea j timothy jull, andrew steele, carbon, contamination, dead sea scrolls, evidence, geoscientist, keck foundation, life, life on earth, macromolecules, mars, martian basalts, martian history, martian life, martian meteorites, molecules, NASA, organic carbon, shroud of turin, university of arizona, viking

The findings provide insight into the chemical processes taking place on Mars and will help aid future quests for evidence of ancient or modern Martian life.

Carbon in some Martian meteorites came from Mars but not from life on Mars, according to new research from an international team that includes a University of Arizona geoscientist.

Molecules containing large chains of carbon and hydrogen – the building blocks of all life on Earth – have been the targets of missions to Mars from Viking to the present day.

Scientists have disagreed about how the organic carbon found in meteorites from Mars was formed and whether or not it came from Mars. (more…)

Correct Protein Folding:

By Guest PostFebruary 26, 2012Sciencealzheimers, amino acids, atp hydrolysis, atp molecules, biomolecular nanomachines, cancer, chain, chaperonin, corie ralston, crystal structure, diseases, eukaryotes, gold standard, jose pereira, light sources, macromolecules, Nanotechnology, nicholai douglas, nucleotide, parkinson's, paul adams, prokaryotes, protein, ramya kumar, xray beams

*Berkeley Lab Researchers Identify Structure of Key Control Element Behind Protein Misfolding That Can Lead to Disease*

The gold standard for nanotechnology is nature’s own proteins. These biomolecular nanomachines – macromolecules forged from peptide chains of amino acids – are able to fold themselves into a dazzling multitude of shapes and forms that enable them to carry out an equally dazzling multitude of functions fundamental to life. As important as protein folding is to virtually all biological systems, the mechanisms behind this process have remained a mystery. The fog, however, is being lifted.

A team of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab), using the exceptionally bright and powerful x-ray beams of the Advanced Light Source, have determined the crystal structure of a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins. The incorrect or “misfolding” of proteins has been linked to many diseases, including Alzheimer’s, Parkinson’s and some forms of cancer. (more…)

Tag Archives: macromolecules

Comparing Proteins at a Glance

Bold Move Forward in Molecular Analyses

Carbon from Martian Meteorites Not Evidence of Life

Correct Protein Folding: