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Protein interplay in muscle tied to life span

By Guest PostDecember 1, 2013Health, Scienceactivin equivalent, alzheimer's disease, ana maria hernandez, atg8a, autophagy, brain, brown university biologists, central culprit, chain, dawdle, dfoxo, female reproductive system, fly version, fruit flies, gene, hua bai, human aging biology, insulin producing cells, ipcs, life span, mammalian protein, marc tatar, menstrual cycle, misfolded proteins, molecular event, muscle, muscle fibers, muscle tissue, natural mechanism, ping kang, protein degradation, protein interplay, rolf bodmer

Brown University biologists have uncovered a complicated chain of molecular events that leads from insulin to protein degradation in muscles and significantly diminished life span in fruit flies. The new study in PLoS Genetics, which may have broad implications across species, identifies the fly version of the mammalian protein activin as the central culprit in the process.

PROVIDENCE, R.I. [Brown University] — Fruit flies are notoriously short-lived but scientists interested in the biology of aging in all animals have begun to understand why some fruit flies live longer than others. They have documented a direct association between insulin and life span, for example, and have observed a tradeoff between prolific reproduction and longevity. A new study, which may have broad implications across species, ties those findings more closely together by tracing an insulin signaling cascade through to protein quality control in muscle tissue and shortened life span. (more…)

U.S. Manufacturers Bringing Work Home from Overseas

By Guest PostOctober 3, 2012Economyaerospace, chain, China, cultural barrier, defense, domestic soil, Economy, electronics, erosion, expert, factor, firm, global risk, India, industry, intellectual property, kenneth petersen, labor cost, language, lisa ellram, manufacturing operation, medical, michigan, oil price, overseas, political instability, problem, product quality, state university, supply, surgical supplies, time zone, tobias schoenherr, transportation cost, united states, US, wendy tate

EAST LANSING, Mich. — Increasingly, U.S. firms are moving or considering moving their manufacturing operations back to domestic soil from overseas, finds a new study co-authored by a Michigan State University supply chain expert.

Fueling the trend are rising labor costs in emerging countries, high oil prices and increasing transportation costs, global risks such as political instability and other factors, said Tobias Schoenherr.

“Going overseas is not the panacea that it was thought of just a decade or so ago,” said Schoenherr, assistant professor in MSU’s top-ranked Department of Supply Chain Management. “Companies have realized the challenges and thus are moving back to the United States.” (more…)

Correct Protein Folding:

By Guest PostFebruary 26, 2012Sciencealzheimers, amino acids, atp hydrolysis, atp molecules, biomolecular nanomachines, cancer, chain, chaperonin, corie ralston, crystal structure, diseases, eukaryotes, gold standard, jose pereira, light sources, macromolecules, Nanotechnology, nicholai douglas, nucleotide, parkinson's, paul adams, prokaryotes, protein, ramya kumar, xray beams

*Berkeley Lab Researchers Identify Structure of Key Control Element Behind Protein Misfolding That Can Lead to Disease*

The gold standard for nanotechnology is nature’s own proteins. These biomolecular nanomachines – macromolecules forged from peptide chains of amino acids – are able to fold themselves into a dazzling multitude of shapes and forms that enable them to carry out an equally dazzling multitude of functions fundamental to life. As important as protein folding is to virtually all biological systems, the mechanisms behind this process have remained a mystery. The fog, however, is being lifted.

A team of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab), using the exceptionally bright and powerful x-ray beams of the Advanced Light Source, have determined the crystal structure of a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins. The incorrect or “misfolding” of proteins has been linked to many diseases, including Alzheimer’s, Parkinson’s and some forms of cancer. (more…)

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Protein interplay in muscle tied to life span

U.S. Manufacturers Bringing Work Home from Overseas

Correct Protein Folding: