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Comparing Proteins at a Glance

Berkeley Lab Researchers Unveil Technique for Easy Comparisons of Proteins in Solution

A revolutionary X-ray analytical technique that enables researchers at a glance to identify structural similarities and differences between multiple proteins under a variety of conditions has been developed by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). As a demonstration, the researchers used this technique to gain valuable new insight into a protein that is a prime target for cancer chemotherapy.

“Proteins and other biological macromolecules are moving machines whose power is often derived from how their structural conformations change in response to their environment,” says Greg Hura, a scientist with Berkeley Lab’s Physical Biosciences Division. “Knowing what makes a protein change has incredible value, much like knowing that stepping on a gas pedal makes the wheels of a car spin.” (more…)

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