The first dynamic regulatory system that prevents the build-up of toxic metabolites in engineered microbes has been reported by a team of researchers with the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI). The JBEI researchers used their system to double the production in Escherichia coli (E. coli) of amorphadiene, a precursor to the premier antimalarial drug artemisinin.
Using genome-wide transcriptional analysis, the JBEI researchers identified native regions of DNA – called “promoters” – in E. coli that respond to toxic metabolites by promoting the expression of protective genes. They then developed a system based on these promoters for regulating artificial metabolic pathways engineered into the E.coli to enable the bacterium to produce amorphadiene. (more…)
The human face is as unique as a fingerprint, no one else looks exactly like you. But what is it that makes facial morphology so distinct? Certainly genetics play a major role as evident in the similarities between parents and their children, but what is it in our DNA that fine-tunes the genetics so that siblings – especially identical twins – resemble one another but look different from unrelated individuals? A new study by researchers at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) has now shown that gene enhancers – regulatory sequences of DNA that act to turn-on or amplify the expression of a specific gene – are major players in craniofacial development. (more…)
Collaboration at Berkeley Lab’s Advanced Light Source Induces High Temperature Superconductivity in a Toplogical Insulator
Reliable quantum computing would make it possible to solve certain types of extremely complex technological problems millions of times faster than today’s most powerful supercomputers. Other types of problems that quantum computing could tackle would not even be feasible with today’s fastest machines. The key word is “reliable.” If the enormous potential of quantum computing is to be fully realized, scientists must learn to create “fault-tolerant” quantum computers. A small but important step toward this goal has been achieved by an international collaboration of researchers from China’s Tsinghua University and the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) working at the Advanced Light Source (ALS). (more…)
Daya Bay neutrino experiment releases high-precision measurement of subatomic shape shifting and new result on differences among neutrino masses
The international Daya Bay Collaboration has announced new results about the transformations of neutrinos – elusive, ghostlike particles that carry invaluable clues about the makeup of the early universe. The latest findings include the collaboration’s first data on how neutrino oscillation – in which neutrinos mix and change into other “flavors,” or types, as they travel – varies with neutrino energy, allowing the measurement of a key difference in neutrino masses known as mass splitting.
“Understanding the subtle details of neutrino oscillations and other properties of these shape-shifting particles may help resolve some of the deepest mysteries of our universe,” said Jim Siegrist, Associate Director of Science for High Energy Physics at the U.S. Department of Energy (DOE), the primary funder of U.S. participation in Daya Bay. (more…)
In the five years since the China Energy Group of the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) released its last edition of the China Energy Databook, China has achieved two dubious distinctions: it surpassed the United States in energy consumption and it surpassed the United States in energy-related emissions of carbon dioxide, becoming the world leader on both scores.
With these important shifts in the global energy landscape, the eighth edition of the China Energy Databook is being released this week. The Databook is the most comprehensive publicly available resource known to exist covering China’s energy and environmental statistics. The China Energy Group researchers have amassed an enormous trove of data from firsthand sources and organized much of it into a relational database, making it far more useful for research and analytical purposes. (more…)
Berkeley Lab experts contribute to IPCC 5th Assessment Report.
Over the next century, most of the continents are on track to become considerably warmer, with more hot extremes and fewer cold extremes. Precipitation will increase in some parts of the world but will decrease in other parts. These are some of the conclusions reached by Lawrence Berkeley National Laboratory (Berkeley Lab) scientist Michael Wehner and his co-authors on the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC).
Wehner, a climate scientist in Berkeley Lab’s Computational Research Division, and William Collins, head of the Lab’s Climate Sciences Department, were lead authors on the IPCC report’s chapters on long-term climate change projections and climate models, respectively. They are among more than 200 lead authors from more than 30 countries in IPCC’s Working Group I. Their report released today provides a comprehensive assessment of the physical science basis of climate change. (more…)
Berkeley Lab Researchers at Joint Center for Artificial Photosynthesis Make Unique Semiconductor/Catalyst Construct
In the search for clean, green sustainable energy sources to meet human needs for generations to come, perhaps no technology matches the ultimate potential of artificial photosynthesis. Bionic leaves that could produce energy-dense fuels from nothing more than sunlight, water and atmosphere-warming carbon dioxide, with no byproducts other than oxygen, represent an ideal alternative to fossil fuels but also pose numerous scientific challenges. A major step toward meeting at least one of these challenges has been achieved by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) working at the Joint Center for Artificial Photosynthesis (JCAP).
“We’ve developed a method by which molecular hydrogen-producing catalysts can be interfaced with a semiconductor that absorbs visible light,” says Gary Moore, a chemist with Berkeley Lab’s Physical Biosciences Division and principal investigator for JCAP. “Our experimental results indicate that the catalyst and the light-absorber are interfaced structurally as well as functionally.” (more…)
Question: “What did you do this summer?” Answer: “I built the Advanced Light Source.”
It’s the rare undergraduate who can say they spent their vacation building a third-generation synchrotron, but that’s exactly what Seno Rekawa did in the summer of 1991 as an intern at Lawrence Berkeley National Laboratory. It was an auspicious start to his career. Less than five years later, he was working as a full-time engineer at Berkeley Lab and now is a regular mentor to budding high school and college engineers.
Berkeley Lab’s Center for Science and Engineering Education (CSEE), with its range of internship offerings, helps to fulfill one of the Lab’s mandates, which is to inspire and prepare this country’s next generation of scientists, engineers and technicians. This year more than 70 current and recent college students and almost 20 high school and college instructors participated in a CSEE program, working with Berkeley Lab researchers on science projects spanning from cancer research to cosmology to biofuels. (more…)
