Berkeley Lab scientists lead broadest survey yet of RNA activity in any animal
A consortium led by scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) has conducted the largest survey yet of how information encoded in an animal genome is processed in different organs, stages of development, and environmental conditions. Their findings paint a new picture of how genes function in the nervous system and in response to environmental stress. (more…)
Berkeley Researchers Show Expanded Role for Guide RNA in Cas9 Interactions with DNA
The potential is there for bacteria and other microbes to be genetically engineered to perform a cornucopia of valuable goods and services, from the production of safer, more effective medicines and clean, green, sustainable fuels, to the clean-up and restoration of our air, water and land. Cells from eukaryotic organisms can also be modified for research or to fight disease. To achieve these and other worthy goals, the ability to precisely edit the instructions contained within a target’s genome is a must. A powerful new tool for genome editing and gene regulation has emerged in the form of a family of enzymes known as Cas9, which plays a critical role in the bacterial immune system. Cas9 should become an even more valuable tool with the creation of the first detailed picture of its three-dimensional shape by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley. (more…)
Berkeley Lab’s Advanced Light Source reveals inner-workings of essential protein found throughout life.
Maybe you’ve seen the movies or played with toy Transformers, those shape-shifting machines that morph in response to whatever challenge they face. It turns out that DNA-repair machines in your cells use a similar approach to fight cancer and other diseases, according to research led by scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab).
As reported in a pair of new studies, the scientists gained new insights into how a protein complex called Mre11-Rad50 reshapes itself to take on different DNA-repair tasks. (more…)
Technique From Berkeley Lab’s Molecular Foundry Could Also Work with Graphene
“Cool it!” That’s a prime directive for microprocessor chips and a promising new solution to meeting this imperative is in the offing. Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a “process friendly” technique that would enable the cooling of microprocessor chips through carbon nanotubes.
Frank Ogletree, a physicist with Berkeley Lab’s Materials Sciences Division, led a study in which organic molecules were used to form strong covalent bonds between carbon nanotubes and metal surfaces. This improved by six-fold the flow of heat from the metal to the carbon nanotubes, paving the way for faster, more efficient cooling of computer chips. The technique is done through gas vapor or liquid chemistry at low temperatures, making it suitable for the manufacturing of computer chips. (more…)
Researchers at Berkeley Lab’s Advanced Light Source Find New Form of Quantum Matter
The discovery of what is essentially a 3D version of graphene – the 2D sheets of carbon through which electrons race at many times the speed at which they move through silicon – promises exciting new things to come for the high-tech industry, including much faster transistors and far more compact hard drives. A collaboration of researchers at the U.S Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has discovered that sodium bismuthide can exist as a form of quantum matter called a three-dimensional topological Dirac semi-metal (3DTDS). This is the first experimental confirmation of 3D Dirac fermions in the interior or bulk of a material, a novel state that was only recently proposed by theorists. (more…)
How’s this for innovative: A Berkeley Lab-led team hopes to engineer a new enzyme that efficiently converts methane to liquid transportation fuel.
“There’s a lot of methane available, and we want to develop a new way to harness it as an energy source for vehicles,” says Christer Jansson, a biochemist in Berkeley Lab’s Earth Sciences Division who heads the effort. (more…)
Berkeley Lab Researchers Make a Powerful New Microscale Torsional Muscle/Motor from Vanadium Dioxide
Vanadium dioxide is poised to join the pantheon of superstars in the materials world. Already prized for its extraordinary ability to change size, shape and physical identity, vanadium dioxide can now add muscle power to its attributes. A team of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has demonstrated a micro-sized robotic torsional muscle/motor made from vanadium dioxide that for its size is a thousand times more powerful than a human muscle, able to catapult objects 50 times heavier than itself over a distance five times its length within 60 milliseconds – faster than the blink of an eye. (more…)
Researchers at Berkeley Lab’s Molecular Foundry Create First Soluble 2D Supramolecular Organic Frameworks
Supramolecular chemistry, aka chemistry beyond the molecule, in which molecules and molecular complexes are held together by non-covalent bonds, is just beginning to come into its own with the emergence of nanotechnology. Metal-organic frameworks (MOFs) are commanding much of the attention because of their appetite for greenhouse gases, but a new player has joined the field – supramolecular organic frameworks (SOFs). Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have unveiled the first two-dimensional SOFs that self-assemble in solution, an important breakthrough that holds implications for sensing and separation technologies, energy sciences, and, perhaps most importantly, biomimetics. (more…)
