Tag Archives: university of california

Sweet Success: Berkeley Lab Researchers Find Way to Catalyze More Sugars from Biomass

By Guest PostMay 4, 2013Scienceachilles heel, advanced biofuels, amorphous, berkeley lab, biofuel production, biomass of grasses, carbon into atmosphere, catalysis, catalytic activity, cellulase enzymes, cellulose classification system, cellulosic biomass, crystalline, douglas clark, enzyme cocktails, enzyme synergy, fermentable sugars, fossil fuels, harvey blanch, industrial manufacturing processes, jan liphardt, jerome fox, light microscopy technique, localization microscopy, palm, palm technology, photo activated, solid surfaces, substrate heterogeneity, sweet success, synergistic activity, ultrahigh precision, united states, university of california

Catalysis may initiate almost all modern industrial manufacturing processes, but catalytic activity on solid surfaces is poorly understood. This is especially true for the cellulase enzymes used to release fermentable sugars from cellulosic biomass for the production of advanced biofuels. Now, researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) through support from the Energy Biosciences Institute (EBI) have literally shed new light on cellulase catalysis.

Using an ultrahigh-precision visible light microscopy technique called PALM – for Photo-Activated Localization Microscopy – the researchers have found a way to improve the collective catalytic activity of enzyme cocktails that can boost the yields of sugars for making fuels. Increasing the sugar yields from cellulosic biomass to help bring down biofuel production costs is essential for the widespread commercial adoption of these fuels. (more…)

Diversity programs give illusion of corporate fairness, study shows

By Guest PostApril 12, 2013Economybrenda major, cheryl kaiser, civil rights law, discrimination complaints, diversity programs, diversity statement, diversity training programs, jenessa shapiro, laura brady, rational assumptions, santa barbara, tessa dover, university of california, university of washington, work environments, workplace diversity programs

Diversity training programs lead people to believe that work environments are fair even when given evidence of hiring, promotion or salary inequities, according to new findings by psychologists at the University of Washington and other universities.

The study also revealed that participants, all of whom were white, were less likely to take discrimination complaints seriously against companies who had diversity programs. (more…)

Misregulated genes may have big autism role

By Guest PostApril 1, 2013Healthautism, autism cerebral cortex, bank, biochemical exchanges, brain tissue, brains of children, brown university, christianson syndrome, daniel geschwind, endosomes of cells, epilepsy, eric morrow, genetic pathway, human behavior, irinia voineagu, karoly mirnics, key molecular player, krassimira garbett, los angeles, messenger rna, misregulated genes, mutations, nhe6, nhe9, proteins, raw data, statistical analysis, university of california, vanderbilt university

A genetic pathway involving proteins in the endosomes of cells appears to be misregulated in the brains of children with autism, according to a newly published statistical analysis in the journal Molecular Psychiatry. Previously the genes were shown to cause rare forms of the disease but the new study suggests they have a wider role.

PROVIDENCE, R.I. [Brown University] — A new study finds that two genes individually associated with rare autism-related disorders are also jointly linked to more general forms of autism. The finding suggests a new genetic pathway to investigate in general autism research. (more…)

Surprising Control over Photoelectrons from a Topological Insulator

By Guest PostMarch 24, 2013Science3d topological insulators, alessandra lanzara, als, angle resolved, arpes, atoms, berkeley lab, chris jozwiak, data collection, dirac point, dung hai lee, electronic states, energy momentum diagrams, field of spintronics, flight analyzer, german, graphene, incident light, laser beam, magnetic surface, momentum space, p polarized, photoelectrons, photoemission spectroscopy, quantum computing, s polarization, s polarized, senkrecht, spin polarized, spin time, steve louie, strange crystalline materials, tis, topological insulator, university of california, zahid hussain

Berkeley Lab scientists discover how a photon beam can flip the spin polarization of electrons emitted from an exciting new material

Plain-looking but inherently strange crystalline materials called 3D topological insulators (TIs) are all the rage in materials science. Even at room temperature, a single chunk of TI is a good insulator in the bulk, yet behaves like a metal on its surface.

Researchers find TIs exciting partly because the electrons that flow swiftly across their surfaces are “spin polarized”: the electron’s spin is locked to its momentum, perpendicular to the direction of travel. These interesting electronic states promise many uses – some exotic, like observing never-before-seen fundamental particles, but many practical, including building more versatile and efficient high-tech gadgets, or, further into the future, platforms for quantum computing. (more…)

Engineering Bacterial Live Wires

By Guest PostMarch 13, 2013Sciencebacterial species, berkeley lab, bioelectronic systems, biological wire, caroline ajo franklin, cell membranes, cheryl goldbeck, common language, e coli, electron, electronic communication systems, energy, energy conversion techniques, guillaume cambray, heather jensen, information transfer, largus angenent, living cell, matt hepler, metabolic pathways, michaela teravest, molecular foundry, mr 1, mtrcab pathway, nanocrystalline iron oxide, nicole beedle, protein complex, shewanella oneidensis, strain, synthesis, university of california, vivek mutalik, yancey appling

Berkeley Lab scientists discover the balance that allows electricity to flow between cells and electronics

Just like electronics, living cells use electrons for energy and information transfer. Despite electrons being a common “language” of the living and electronic worlds, living cells cannot speak to our largely technological realm. Cell membranes are largely to blame for this inability to plug cells into our computers: they form a greasy barrier that tightly controls charge balance in a cell. Thus, giving a cell the ability to communicate directly with an electrode would lead to enormous opportunities in the development of new energy conversion techniques, fuel production, biological reporters, or new forms of bioelectronic systems. (more…)

Searching for the Solar System’s Chemical Recipe

By Guest PostMarch 4, 2013Scienceasteroids, basic ingredients, beams of vuv, carbon monoxide, clouds, comets, dust, elements, gas molecules, gas phase photodynamics, genesis mission, hydrogen sulfide, interplanetary ice, isotope ratios, isotopic differences, john heidenreich, mark thiemens, mass spectrometry, mean ocean water, moons, musahid musa ahmed, nanometer wavelength range, NASA, nitrogen, one extra neutron, origin, oxygen 17, oxygen isotope puzzle, photochemistry, physical factors, planets, primitive solar nebula, raindrops, san diego, smow, solar system recipe, standard, subrata chakraborty, teresa jackson, ultraclean aluminum foil, university of california, vacuum ultraviolet light, vuv wavelengths, x axis, y axis

Berkeley Lab’s Chemical Dynamics Beamline points to why isotope ratios in interplanetary dust and meteorites differ from Earth’s

By studying the origins of different isotope ratios among the elements that make up today’s smorgasbord of planets, moons, comets, asteroids, and interplanetary ice and dust, Mark Thiemens and his colleagues hope to learn how our solar system evolved. Thiemens, Dean of the Division of Physical Sciences at the University of California, San Diego, has worked on this problem for over three decades.

In recent years his team has found the Chemical Dynamics Beamline of the Advanced Light Source (ALS) at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) to be an invaluable tool for examining how photochemistry determines the basic ingredients in the solar system recipe. (more…)

A Cyclotron’s Long Journey Home

By Guest PostMarch 2, 2013Scienceamerican science, atom smashers, atomic energy commission, aundra richards, berkeley hills, berkeley lab, brass cyclotron, circular particle accelerator, cyclotrons, david shirley, diameter, electron volts, ernest o lawrence, hall of science, hydrogen atoms, invention, kinetic energy, lab history, Large Hadron Collider, light, london science museum, merry go round, modern particle physics, natalie roe, nobel prize, nuclei, pamela patterson, paul alivisatos, protons, secret, Smithsonian, speed, the royal society, uk museum, university of california, Washington, yale university

One of the world’s first working circular particle accelerators returns to Berkeley Lab—75 years later.

Seventy-five years after one of the world’s first working cyclotrons was handed to the London Science Museum, it has returned to its birthplace in the Berkeley hills, where the man who invented it, Ernest O. Lawrence, helped launch the field of modern particle physics as well as the national laboratory that would bear his name, Lawrence Berkeley National Laboratory.

On Jan. 9, 1932 the brass cyclotron—which measures 26 inches from end to end and whose accelerating chamber measures just 11 inches in diameter—was successfully used to boost protons to energies of 1.22 million electron volts. Its return to Berkeley Lab caps a decades-long saga in which various parties endeavored to secure the cyclotron’s return from London, but the persistence of Pamela Patterson, who chronicles Berkeley Lab’s history as managing editor of its website, finally paid off. (more…)

New Details on the Molecular Machinery of Cancer

By Guest PostFebruary 17, 2013Scienceactivation, adam smith, addition of phosphate, anton arkhipov, autophosphorylation, berkeley lab, cancer, cancer therapies, cancers, cell surface protein, cellular functions, computational modeling, egf ligand, egfr, epidermal growth factor, fluorescence spectroscopy, gene, immune system, jay groves, john kuriyan, ligand induced dimerization, living cells, molecular machinery, nicholas endres, nuclear magnetic resonance, photon, post translational process, protein activation, quantitative approach, quantitative biology techniques, rahul das, receptor, receptor tyrosine kinases, single compound molecule, specific proteins, t-cell receptors, time resolved, uc, university of california

Berkeley Lab Researchers Resolve EGFR Activation Mystery

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

“The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer,” says chemist Jay Groves, one of the leaders of this research. “Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we’ve determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand.” (more…)