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Scientists Identify Novel Pathway for T Cell Activation in Leprosy

By Guest PostApril 2, 2012Sciencecell signaling molecule, delphine j lee, dendritic cells, immune cells, infection, interleukin 32, lepromatous leprosy, leprosy, leprosy pathogen, mirjam schenk, monocytes, mycobacteria, mycobacterium leprae, nod2, peter a sieling, protein, robert modlin, skin, stephan r krutzik, t cells, tlr2, tuberloid leprosy, white blood cell

*Findings may help lead to new treatments for infectious diseases, cancer*

UCLA researchers have pinpointed a new mechanism that potently activates T cells, the group of white blood cells that plays a major role in fighting infections.

The team specifically studied how dendritic cells, immune cells located at the site of an infection, become more specialized to fight the leprosy pathogen known as Mycobacterium leprae. Dendritic cells, like scouts in the field of a military operation, deliver key information about an invading pathogen that helps activate the T cells in launching a more effective attack. (more…)

Newly Found Protein Helps Cells Build Tissues

By Guest PostApril 2, 2012Scienceantibody, bmps, bone morphogenic proteins, brown university, enzyme, fruit flies, gbb, gbb38, glass bottom boat, guillermo marques, kristi wharton, molecule, protein, signaling molecule, takuya akiyama, wing tissue

University biologists have found a new molecule in fruit flies that is key to the information exchange needed to build wings properly. They have also uncovered evidence that an analogous protein may exist in people and may be associated with problems such as cleft lip, or premature ovarian failure.

PROVIDENCE, R.I. [Brown University] — As they work together to form body parts, cells in developing organisms communicate like workers at a construction site. The discovery of a new signaling molecule in flies by Brown University biologists not only helps explain how cells send many long-haul messages, but also provides new clues for researchers who study how human development goes awry, for instance in cases of cleft lip and palate. (more…)

Curcumin Shows Promise in Attacking Parkinson’s Disease

By Guest PostApril 1, 2012Healthalpha synuclein protein, amino acid, basir ahmad, body temperature, clumping, curcumin, disease, folding, lisa lapidus, parkinson's, protein, spice, technique, turmeric

EAST LANSING, Mich. — Curcumin, a compound found in the spice turmeric, is proving effective at preventing clumping of a protein involved in Parkinson’s disease, says a Michigan State University researcher.

A team of researchers led by Basir Ahmad, an MSU postdoctoral researcher, demonstrated earlier this year that slow-wriggling alpha-synuclein proteins are the cause of clumping, or aggregation, which is the first step of diseases such as Parkinson’s. A new study led by Ahmad, which appears in the current issue of the Journal of Biological Chemistry, shows that curcumin can help prevent clumping. (more…)

Tiny Reader Makes Fast, Cheap DNA Sequencing Feasible

By Guest PostMarch 29, 2012Scienceaddiction, adenine, andrew laszlo, cancer, cytosine, diabetes, dna molecule, dna sequencing, elizabeth manrao, enzyme, guanine, ian derrington, jens gundlach, kyle langford, matthew hopper, millisecond, molecular motor, mycobacterium, nanopore, nanoscale sensor, nathaniel gillgren, nucleotide, protein, thymine

Researchers have devised a nanoscale sensor to electronically read the sequence of a single DNA molecule, a technique that is fast and inexpensive and could make DNA sequencing widely available.

The technique could lead to affordable personalized medicine, potentially revealing predispositions for afflictions such as cancer, diabetes or addiction. (more…)

The Gene That Can Transform Mild Influenza in to a Life Threatening Disease

By Guest PostMarch 26, 2012Health, Scienceantiviral, cell, deenan pillay, disease, gene variant, genetic finding, greg towers, h1n1 pandemic influenza, hiv, ifitm3 gene, infection, influenza, life threatening, paul kellam, protein, sir mark walport, swine flu, ucl, variant, virus infection

A genetic finding could help to explain why influenza becomes a life-threatening disease for some people, and yet has only a mild effect on others. Collaborative research led by scientists at UCL and the Wellcome Trust Sanger Institute found that people who carry a particular variant of the IFITM3 gene are significantly more likely to be hospitalised when they fall ill with influenza than those who carry other variants.

The gene plays a critical role in protecting the body against infection with influenza and a rare version of it appears to make people more susceptible to severe forms of the disease. The results are published in the journal Nature. (more…)

‘Bed-of-Nails’ Breast Implant Deters Cancer Cells

By Guest PostMarch 26, 2012Healthbed of nails, blood vessel, breast cancer, brown university, cancer tumor, cell, cell function, chemical analysis, electron spectroscopy, lijuan zhang, malignant, michael platek, nanoscale, Nanotechnology, plga, protein, regrowth, thomas webster, tumor, united states, university of rhode island, vegf

Researchers at Brown University have created an implant that appears to deter breast cancer cell regrowth. Made from a common federally approved polymer, the implant is the first to be modified at the nanoscale in a way that causes a reduction in the blood-vessel architecture that breast cancer tumors depend upon, while also attracting healthy breast cells. Results are published in Nanotechnology.

PROVIDENCE, R.I. [Brown University] — One in eight women in the United States will develop breast cancer. Of those, many will undergo surgery to remove the tumor and will require some kind of breast reconstruction afterward, often involving implants. Cancer is an elusive target, though, and malignant cells return for as many as one-fifth of women originally diagnosed, according to the American Cancer Society. (more…)

How Megakaryocytes Get so Big — and The Bad Things That Happen When They Don’t

By Guest PostMarch 2, 2012Scienceblood cells, cell division, diane krause, DNA, ect2, ee chun cheng, elenoe smith, endomitosis, gef h1, gene, giant blood cells, guanine exchange factors, krause lab, leukemia, lin wang, malfunction, malignant leukemias, megakaryoblastic leukemias, megakaryocyte maturation, megakaryocytes, mkl1, mutant, platelets, process, protein, sharon lin, siying zou, stephanie halene, supernova, yuan gao

Yale researchers have discovered how megakaryocytes — giant blood cells that produce wound-healing platelets — manage to grow 10 to 15 times larger than other blood cells.

The findings, to be published March 13 in the journal Developmental Cell, also hint at how a malfunction in this process may cause a form of leukemia. (more…)

It Takes Two to Tango: Pairs of Entwined Proteins Handle The Stress

By Guest PostMarch 2, 2012Sciencebacterial protein, bleach, cell paper, dana reichmann, dance floor, function, helper protein, hsp33, jim erickson, michael fitzgerald, molecular chaperone, oxidants, protein, protein folding process, stress specific, tango, university of michigan, ursula jakob, ying xu

ANN ARBOR, Mich.— Imagine two tango dancers sweeping across the dance floor and suddenly encountering a slick spot. To avoid a slip or even a nasty tumble, the pair must work together to support one another and glide safely through the stressful moment.

In a similar way, a certain type of helper protein called a stress-specific molecular chaperone prevents its client proteins from collapsing during stressful situations by uncoiling a long, supportive arm that wraps around them, a University of Michigan-led research team has shown. (more…)

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