*Findings may help lead to new treatments for infectious diseases, cancer*
UCLA researchers have pinpointed a new mechanism that potently activates T cells, the group of white blood cells that plays a major role in fighting infections.
The team specifically studied how dendritic cells, immune cells located at the site of an infection, become more specialized to fight the leprosy pathogen known as Mycobacterium leprae. Dendritic cells, like scouts in the field of a military operation, deliver key information about an invading pathogen that helps activate the T cells in launching a more effective attack. (more…)
University biologists have found a new molecule in fruit flies that is key to the information exchange needed to build wings properly. They have also uncovered evidence that an analogous protein may exist in people and may be associated with problems such as cleft lip, or premature ovarian failure.
PROVIDENCE, R.I. [Brown University] — As they work together to form body parts, cells in developing organisms communicate like workers at a construction site. The discovery of a new signaling molecule in flies by Brown University biologists not only helps explain how cells send many long-haul messages, but also provides new clues for researchers who study how human development goes awry, for instance in cases of cleft lip and palate. (more…)
EAST LANSING, Mich. — Curcumin, a compound found in the spice turmeric, is proving effective at preventing clumping of a protein involved in Parkinson’s disease, says a Michigan State University researcher.
A team of researchers led by Basir Ahmad, an MSU postdoctoral researcher, demonstrated earlier this year that slow-wriggling alpha-synuclein proteins are the cause of clumping, or aggregation, which is the first step of diseases such as Parkinson’s. A new study led by Ahmad, which appears in the current issue of the Journal of Biological Chemistry, shows that curcumin can help prevent clumping. (more…)
Researchers have devised a nanoscale sensor to electronically read the sequence of a single DNA molecule, a technique that is fast and inexpensive and could make DNA sequencing widely available.
The technique could lead to affordable personalized medicine, potentially revealing predispositions for afflictions such as cancer, diabetes or addiction. (more…)
Researchers at Brown University have created an implant that appears to deter breast cancer cell regrowth. Made from a common federally approved polymer, the implant is the first to be modified at the nanoscale in a way that causes a reduction in the blood-vessel architecture that breast cancer tumors depend upon, while also attracting healthy breast cells. Results are published in Nanotechnology.
PROVIDENCE, R.I. [Brown University] — One in eight women in the United States will develop breast cancer. Of those, many will undergo surgery to remove the tumor and will require some kind of breast reconstruction afterward, often involving implants. Cancer is an elusive target, though, and malignant cells return for as many as one-fifth of women originally diagnosed, according to the American Cancer Society. (more…)
Yale researchers have discovered how megakaryocytes — giant blood cells that produce wound-healing platelets — manage to grow 10 to 15 times larger than other blood cells.
The findings, to be published March 13 in the journal Developmental Cell, also hint at how a malfunction in this process may cause a form of leukemia. (more…)
ANN ARBOR, Mich.— Imagine two tango dancers sweeping across the dance floor and suddenly encountering a slick spot. To avoid a slip or even a nasty tumble, the pair must work together to support one another and glide safely through the stressful moment.
In a similar way, a certain type of helper protein called a stress-specific molecular chaperone prevents its client proteins from collapsing during stressful situations by uncoiling a long, supportive arm that wraps around them, a University of Michigan-led research team has shown. (more…)
*Berkeley Lab Researchers Identify Structure of Key Control Element Behind Protein Misfolding That Can Lead to Disease*
The gold standard for nanotechnology is nature’s own proteins. These biomolecular nanomachines – macromolecules forged from peptide chains of amino acids – are able to fold themselves into a dazzling multitude of shapes and forms that enable them to carry out an equally dazzling multitude of functions fundamental to life. As important as protein folding is to virtually all biological systems, the mechanisms behind this process have remained a mystery. The fog, however, is being lifted.
A team of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab), using the exceptionally bright and powerful x-ray beams of the Advanced Light Source, have determined the crystal structure of a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins. The incorrect or “misfolding” of proteins has been linked to many diseases, including Alzheimer’s, Parkinson’s and some forms of cancer. (more…)
