The deep biosphere—the realm of sediments far below the seafloor—harbors a vast ecosystem of bacteria, archaea, and fungi that are actively metabolizing, proliferating, and moving, according a new study by scientists at Woods Hole Oceanographic Institution (WHOI) and the University of Delaware (UD).
“This is the first molecular evidence for active cell division in the deep biosphere,” says WHOI postdoctoral investigator Bill Orsi, who was the lead author on the study. Previous studies and models had suggested cells were alive, but whether the cells were actually dividing or not had remained elusive. (more…)
*By studying tumor cell behavior in a novel “scaffold-free” 3-D system, researchers have determined that the protein Pannexin1 may play an important biomechanical role in binding tissues together, an effect that is lost in cancerous cells.*
PROVIDENCE, R.I. [Brown University] — First there is the tumor and then there’s the horrible question of whether the cancerous cells will spread. Scientists increasingly believe that the structural properties of the tumor itself, such as how tightly the tumor cells are packed together, play a decisive role in the progression of the disease. In a new study, researchers show that the protein Pannexin1, known to have tumor-suppressive properties, plays an important role in keeping the cells within a tissue closely packed together, an effect that may be lost with cancer.
“In healthy tissues, the recently discovered protein Pannexin1 may be playing an important role in upholding the mechanical integrity of the tissue,” said first author and Brown University M.D./Ph.D. student Brian Bao. “When we develop cancer, we lose Pannexin1 and we lose this integrity.” (more…)
