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Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

By Guest PostNovember 11, 2012Healthalzheimers, antidepressants, bacterial membrane, berkeley lab, cells, cerebral cortex, chemist, coenzyme q, cognitive decline, compound, cynthia mcmurray, DNA, genetic disorder, genetic mutation, huntingtons disease, loss, mice, mitochondria, mitochondrial function, molecules, motor coordination, motor skills, muscle coordination, neurodegenerative diseases, neuron, organelle, oxidative damage, parkinson's, peter wipf, pittsburgh, power plant, reactive oxygen species, striatum, suppress, survival, symptoms, synthetic antioxidant, university, untreated neuronal cultures, vitamin e, xjb 5 131, xjb treated mice, zhiyin xun

Initial results in mice could lead to new way to fight neurodegenerative diseases

There’s new hope in the fight against Huntington’s disease. A group of researchers that includes scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell’s power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. (more…)

Neuro Researchers Sharpen Our Understanding of Memories

By Guest PostMay 11, 2012Sciencealzheimer's disease, cells, chemical receptor, creb, excitatory neurons, israeli ran, jean claude lacaille, neurodegenerative disorder, neuron interconnection, synapses, understanding of memories, university of montreal

Scientists now have a better understanding of how precise memories are formed thanks to research led by Prof. Jean-Claude Lacaille of the University of Montreal’s Department of Physiology. “In terms of human applications, these findings could help us to better understand memory impairments in neurodegenerative disorders like Alzheimer’s disease,” Lacaille said. The study looks at the cells in our brains, or neurons, and how they work together as a group to form memories.

Chemical receptors at neuron interconnections called synapses enable these cells to form electrical networks that encode memories, and neurons are classified into two groups according to the type of chemical they produce: excitatory, who produce chemicals that increase communication between neurons, and inhibitory, who have the opposite effect, decreasing communication. “Scientists knew that inhibitory cells enable us to refine our memories, to make them specific to a precise set of information,” Lacaille explained. “Our findings explain for the first time how this happens at the molecular and cell levels.” (more…)

When Cells Hit the Wall: UCLA Engineers Put The Squeeze on Cells to Diagnose Disease

By Guest PostMay 6, 2012Health, Scienceaids, amander clark, balloon, cancer, cells, chemical tags, chronic inflammation, cytopathologist, daniel gossett, deformability cytometer, diagnose disease, dino di carlo, dna arrangement, elastic properties, extract information, henry tse, honey, immune disorder, immune system, infection, jian yu rao, mesothelial cells, microfluidic chip, nuclei, rubber balloon, shape, software, steven chu, Technology, ucla engineers, viscous, white blood cells

If you throw a rubber balloon filled with water against a wall, it will spread out and deform on impact, while the same balloon filled with honey, which is more viscous, will deform much less. If the balloon’s elastic rubber was stiffer, an even smaller change in shape would be observed.

By simply analyzing how much a balloon changes shape upon hitting a wall, you can uncover information about its physical properties.

Although cells are not simple sacks of fluid, they also contain viscous and elastic properties related to the membranes that surround them; their internal structural elements, such as organelles; and the packed DNA arrangement in their nuclei. Because variations in these properties can provide information about cells’ state of activity and can be indicative of diseases such as cancer, they are important to measure. (more…)

Researchers Show Prebiotic Can Reduce Severity of Colitis

By Guest PostMay 4, 2012Healthbacterial infection, cells, colitis, colon cancer, elizabeth gardner, fiber supplements, galacto oligosaccharide, good bacteria, gos, gut, inflammation, inflammatory bowel disease, intestinal ailments, jenifer fenton, michigan state university, natural killer, prebiotic, probiotics, synthetic compound

EAST LANSING, Mich. — Researchers at Michigan State University have shown a prebiotic may help the body’s own natural killer cells fight bacterial infection and reduce inflammation, greatly decreasing the risk of colon cancer.

Prebiotics are fiber supplements that serve as food for the trillions of tiny bacteria living in the gut. When taken, they can stimulate the growth of the “good” bacteria. The evolution of prebiotic supplements (as well as probiotics, which are actual bacteria ingested into the system) provide new therapeutic targets for researchers and physicians. (more…)

U.S. Students Need New Way of Learning Science

By Guest PostApril 7, 2012Educationamerican students, atoms, cells, conservation of mass and energy, digital organisms, energy, forces, genomics, k 12 school, michigan state university, next generation, prom se, radiation, research project, Science, science standard, scientific fact, simon billinge, stephen pruitt, student assessment, synthetic biology, systems change, united states, variation, william schmidt

EAST LANSING, Mich. — American students need a dramatically new approach to improve how they learn science, says a noted group of scientists and educators led by Michigan State University professor William Schmidt.

After six years of work, the group has proposed a solution. The 8+1 Science concept calls for a radical overhaul in K-12 schools that moves away from memorizing scientific facts and focuses on helping students understand eight fundamental science concepts. The “plus one” is the importance of inquiry, the practice of asking why things happen around us – and a fundamental part of science. (more…)

Molecular Duo Dictate Weight and Energy Levels, Yale Researchers Find

By Guest PostFebruary 29, 2012Scienceanthony van den pol, bill hathaway, brain control, cells, cellular mechanism, energy, energy balance, hypothalamic neurons, hypothalamus, journal of neuroscience, mch, melanin concentrating hormone, nervous system, neurons, neurotransmitter, thyrotropin releasing hormone, trh, xiaobing zhang, yale university

Yale University researchers have discovered a key cellular mechanism that may help the brain control how much we eat, what we weigh, and how much energy we have.

The findings, published in the Feb. 28 issue of the Journal of Neuroscience, describe the regulation of a family of cells that project throughout the nervous system and originate in an area of the brain call the hypothalamus, which has been long known to control energy balances. (more…)

New Molecule Has Potential to Help Treat Genetic Diseases and HIV

By Guest PostFebruary 13, 2012Scienceamy rhoden smith, austin, base molecule, brent iverson, cells, chromosome, DNA, dna sequence, double helix, garen holman, georgetown, hiv, kenneth johnson, legos, maha zewail foote, molecule, naphthalenetetracarboxylic diimide, ndi, protease inhibitors, sequence of genes, southwestern university, spiral staircase, university of texas, viral dna

AUSTIN, Texas — Chemists at The University of Texas at Austin have created a molecule that’s so good at tangling itself inside the double helix of a DNA sequence that it can stay there for up to 16 days before the DNA liberates itself, much longer than any other molecule reported.

It’s an important step along the path to someday creating drugs that can go after rogue DNA directly. Such drugs would be revolutionary in the treatment of genetic diseases, cancer or retroviruses such as HIV, which incorporate viral DNA directly into the body’s DNA. (more…)

Why Bad Immunity Genes Survive

By Guest PostFebruary 10, 2012Health, Scienceankylosing spondylitis, antagonistic co evolution, antibiotics, arms race, autoimmune diseases, bacteria, cells, cornelius whitney hyzer, gene, genetics, george gilchrist, germs, immune system, infection, infectious diseases, james ruff, jason kubinak, major histocompatibility complex, mhc, mhc variants, mhcs, mice, national science foundation, parasite, pathogens, patricia slev, people, protein, university of utah, variant, vertebrate animals, virus, wayne potts

*Study implicates “arms race” between genes and germs*

Biologists have found new evidence of why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs–even though some of those genes make vertebrate animals susceptible to infections and to autoimmune diseases.

“Major histocompatibility complex” (MHC) proteins are found on the surfaces of most cells in vertebrate animals. They distinguish proteins like themselves from foreign proteins, and trigger an immune response against these foreign invaders. (more…)

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