Tag Archives: rna

University of Toronto Study Demonstrates Impact of Adversity on Early Life Development

By Guest PostOctober 28, 2012Sciencebehavioural geneticist, biology, british columbia, childhood adversity, chris reaume, cifar, dna sequence, drosophila melanogaster, ebbd, Environment, enzyme, evidence, evolutionary biology, food, for, foraging gene, fruit fly, gene, gene robinson, human development, illinois, interaction, james burns, kindergartener, larvae, marla sokolowski, molecular genetics, Nature, neuroscience, pkg, pnas, pre programmed, protein, reproductive fitness, rna, rovers, sitters, tom boyce, toronto, transgenic manipulation, university

Study part of growing body of knowledge surrounding gene-environment interplay

TORONTO, ON – It is time to put the nature versus nurture debate to rest and embrace growing evidence that it is the interaction between biology and environment in early life that influences human development, according to a series of studies recently published in a special edition of the Proceedings of the National Academy of Sciences (PNAS).

“Biologists used to think that our differences are pre-programmed in our genes, while psychologists argued that babies are born with a blank slate and their experience writes on it to shape them into the adults they become. Instead, the important question to be asking is, ‘How is our experience in early life getting embedded in our biology?’” says University of Toronto behavioural geneticist Marla Sokolowski. She is co-editor of the PNAS special edition titled “Biological Embedding of Early Social Adversity: From Fruit Flies to Kindergarteners” along with professors Tom Boyce (University of British Columbia) and Gene Robinson (University of Illinois). (more…)

A Welcome Predictability

By Guest PostOctober 9, 2012Scienceadam arkin, adaptor, advanced phase, bacteria, bacterial, berkeley lab, carbon, cell, chang liu, code, composability, computer hardware, criteria, denise wang, dna nucleotides, element, energy fuel, Environment, escherichia coli, fluorescence microscopy, function, gene, genetic engineering, global cycle, higher order, image, julius lucks, lei qi, medical drug, microbial component, molecules, non coding, plasmid pair, radioactive waste, rna, sustainable production, synthesize protein, synthetic biology, synthetic circuit, thomas segall shapiro, toxic, transcriptional elongation, translational regulator, utrs, vivek mutalik

Berkeley Lab Researchers Develop New Tool for Making Genetic Engineering of Microbial Circuits Reliably Predictable

Synthetic biology is the latest and most advanced phase of genetic engineering, holding great promise for helping to solve some of the world’s most intractable problems, including the sustainable production of energy fuels and critical medical drugs, and the safe removal of toxic and radioactive waste from the environment. However, for synthetic biology to reach its promise, the design and construction of biological systems must be as predictable as the assembly of computer hardware.

An important step towards attaining a higher degree of predictability in synthetic biology has been taken by a group of researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) under the leadership of computational biologist Adam Arkin. Arkin and his team have developed an “adaptor” that makes the genetic engineering of microbial components substantially easier and more predictable by converting regulators of translation into regulators of transcription in Escherichia coli. Transcription and translation make up the two-step process by which the coded instructions of genes are used to synthesize proteins. (more…)

To Cap or Not to Cap: Scientists Find New RNA Phenomenon That Challenges Dogma

By Guest PostSeptember 2, 2012Sciencebaskar bakthavachalu, brian kennedy, cancer, cell, cell life, chandrama mukherjee, cytoplasm, daniel schoenberg, deepak patil, embryonic development, gene, hibernation, messenger rna, mitotic cell cycle, molecule, mrna, neurological activity, ohio state university, protein, rna

COLUMBUS, Ohio – Some RNA molecules spend time in a restful state akin to hibernation rather than automatically carrying out their established job of delivering protein-building instructions in cells, new research suggests.

And instead of being a fluke or a mistake, the research suggests that this restful period appears to be a programmed step for RNA produced by certain types of genes, including some that control cell division and decide where proteins will work in a cell to sustain the cell’s life.

This could mean that protein production in cells is not as clear-cut as biology textbooks suggest, scientists say. (more…)

Locked RNA Editing Yields Odd Fly Behavior

By Guest PostApril 26, 2012Scienceabiotic factor, als, arthur sugden, asli sahin, brown university, cell, charles lawrence, dadar, enzyme adar, epilepsy, factor, fruit fly, function, genetic, jacquelyn dorsky, james jepson, lauren alpert, locking down, lou gehrigs disease, nucleus, organism, phenomenon, protein, rna, robert reenan, suicidal depression, temperature, wallflowers, yiannis savva

At the level of proteins, organisms can adapt by editing their RNA — and an editor can even edit itself. Brown University scientists working with fruit flies found that “locking down” the self-editing process at two extremes created some strange behaviors. They also found that the process is significantly affected by temperature.

PROVIDENCE, R.I. [Brown University] — Because a function of RNA is to be translated as the genetic instructions for the protein-making machinery of cells, RNA editing is the body’s way of fine-tuning the proteins it produces, allowing us to adapt. The enzyme ADAR, which does this editing job in the nervous system of creatures ranging from mice to men, even edits itself. In a new study that examined the self-editing process and locked it down at two extremes in fruit flies, Brown University scientists found some surprising insights into how this “fine-tuning of the fine-tuner” happens, including bizarre behavioral effects that come about when the self-editor can’t edit. (more…)

Organics Probably Formed Easily in Early Solar System

By Guest PostApril 4, 2012Scienceamino acids, amphiphiles, bombard, building blocks, cellular membrane, cometary, computer simulation, DNA, dynamics, fred ciesla, life on earth, meteorite, nasa ames, nucleobases, organic compound, planet, proteins, rna, science express, scott sandford, solar nebula, uchicago, ultraviolet radiation, uv radiation

Complex organic compounds, including many important to life on Earth, were readily produced under conditions that likely prevailed in the primordial solar system. Scientists at the University of Chicago and NASA Ames Research Center came to this conclusion after linking computer simulations to laboratory experiments.

Fred Ciesla, assistant professor in geophysical sciences at UChicago, simulated the dynamics of the solar nebula, the cloud of gas and dust from which the sun and the planets formed. Although every dust particle within the nebula behaved differently, they all experienced the conditions needed for organics to form over a simulated million-year period. (more…)

Yale Study: How Mitochondrial DNA Defects Cause Inherited Deafness

By Guest PostFebruary 21, 2012Scienceapoptosis, cascade, cell, cellular power plants, cellular respiration, cellular structure, chemical modification, disease, dna mutation, energy, enzyme, gene, gerald s shadel, hearing loss, helen dodson, inherited deafness, justin cotney, lei song, methylation, mitochondria, mitochondrial dna mutation, mitochondrial ribosomes, molecular pathway, mouse model, overexpression, programmed cell death, protein, rna, sharen e mccay, timothy e shutt, yale scientist

Yale scientists have discovered the molecular pathway by which maternally inherited deafness appears to occur: Mitochondrial DNA mutations trigger a signaling cascade, resulting in programmed cell death. The study is in the Feb. 17 issue of Cell.

Mitochondria are cellular structures that function as “cellular power plants” because they generate most of the cell’s supply of energy. They contain DNA inherited from one’s mother. Mitochondria determine whether a cell lives or dies via the process of programmed cell death, or apoptosis. (more…)

New 3-D Model of RNA ‘Core Domain’ of Enzyme Telomerase May Offer Clues to Cancer, Aging

By Guest PostNovember 6, 2010Health, Scienceaging, cancer, cells, chromosomes, DNA, dna damage, enzyme, helical extension, juli feigon, medicine, nmr, nobel prize, nuclear magnetic resonance, physiology, proteins, pseudoknot, qi zhang, rna, spectroscopy, telomerase, telomeres, virus

A model representation of telomerase's RNA "core domain," determined by Juli Feigon, Qi Zhang and colleagues in Feigon's UCLA laboratory. Image credit: Juli Feigon, UCLA Chemistry and Biochemistry/PNAS

Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.

But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell.

UCLA biochemists have now produced a three-dimensional structural model of the RNA “core domain” of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say. (more…)

The Genetics of Self-Incompatibility

By Guest PostNovember 6, 2010Nature, Scienceantigens, female, fertilization, genes, genetic, immune response, inbreeding, male, offspring, organism, petunia, petunia pistil, petunia pollen, plant, pollen, proteins, rna, rna-destroying enzyme, seiji takayama, sexual organs, t-cell receptors, teh-hui kao

*Petunias show that the mechanisms behind inbreeding prevention are similar to immune response*

About the image: The female part of the petunia flower secretes an enzyme that is designed to deter pollen tube growth, thereby preventing fertilization. However, in the cases that the pollen has come from a genetically different plant, the pollen produces its own protein that combats the pistil’s enzyme. With the enzyme out of the way, the pollen tube can keep growing and fertilization can occur. Image credit: Zina Deretsky, National Science Foundation

Inbreeding is a bad strategy for any organism, producing weak and problematic offspring. So imagine the challenge of inbreeding prevention in a plant where male and female sexual organs grow right next to each other! Such is the genetic conundrum faced by the petunia. (more…)