Berkeley Lab scientists join an international collaboration to understand how archaea and bacteria work together deep in a cold sulfur spring
In the fall of 2010, Hoi-Ying Holman of the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) was approached by an international team researching a mysterious microbial community discovered deep in cold sulfur springs in southern Germany.
“They told me what they were doing and said, ‘We know what you contributed to the oil-spill research,’” recalls Holman, who heads the Chemical Ecology group in Berkeley Lab’s Earth Sciences Division. “They wondered if I could help them determine the biochemistry of their microbe samples.” (more…)
AMHERST, Mass. – Molecular chaperones have emerged as exciting new potential drug targets, because scientists want to learn how to stop cancer cells, for example, from using chaperones to enable their uncontrolled growth. Now a team of biochemists at the University of Massachusetts Amherst led by Lila Gierasch have deciphered key steps in the mechanism of the Hsp70 molecular machine by “trapping” this chaperone in action, providing a dynamic snapshot of its mechanism.
She and colleagues describe this work in the current issue of Cell. Gierasch’s research on Hsp70 chaperones is supported by a long-running grant to her lab from NIH’s National Institute for General Medical Sciences. (more…)
Microsoft Research develops biometric monitoring system to help patients complete tuberculosis treatment programs.
BANGALORE, India — Dec. 3, 2012 — Giri Prasad, a 33-year-old tailor who lives in Delhi, first noticed the pain below his ribs. He went to see a doctor, but when it didn’t subside, he traveled to the hospital where he eventually learned he had tuberculosis.
“There were many problems because first and foremost, I am the bread earner for the family,” he says. “If the bread earner falls ill, it is a real problem for those who are dependent on him. Here in the city the biggest problem is that if one falls sick, there is no other person who will come help.” (more…)
Some arid lands in the American West degraded by military exercises that date back to General George Patton’s Word War II maneuvers in the Mojave Desert should get a boost from an innovative research project led by the University of Colorado Boulder.
Headed up by CU-Boulder Assistant Professor Nichole Barger, the research team is focused on developing methods to restore biological soil crusts — microbial communities primarily concentrated on soil surfaces critical to decreasing erosion and increasing water retention and soil fertility. Such biological soil crusts, known as “biocrusts,” can cover up to 70 percent of the ground in some arid ecosystems and are dominated by cyanobacteria, lichens, mosses, fungi and bacteria, she said. (more…)
COLUMBUS, Ohio – A South American butterfly flapped its wings, and caused a flurry of nanotechnology research to happen in Ohio.
Researchers here have taken a new look at butterfly wings and rice leaves, and learned things about their microscopic texture that could improve a variety of products.
For example, the researchers were able to clean up to 85 percent of dust off a coated plastic surface that mimicked the texture of a butterfly wing, compared to only 70 percent off a flat surface. (more…)
ANN ARBOR — Nisin, a common food preservative, may slow or stop squamous cell head and neck cancers, a University of Michigan study found.
What makes this particularly good news is that the Food and Drug Administration and the World Health Organization approved nisin as safe for human consumption decades ago, says Yvonne Kapila, the study’s principal investigator and professor at the University of Michigan School of Dentistry. (more…)
Berkeley Lab Researchers Develop New Tool for Making Genetic Engineering of Microbial Circuits Reliably Predictable
Synthetic biology is the latest and most advanced phase of genetic engineering, holding great promise for helping to solve some of the world’s most intractable problems, including the sustainable production of energy fuels and critical medical drugs, and the safe removal of toxic and radioactive waste from the environment. However, for synthetic biology to reach its promise, the design and construction of biological systems must be as predictable as the assembly of computer hardware.
An important step towards attaining a higher degree of predictability in synthetic biology has been taken by a group of researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) under the leadership of computational biologist Adam Arkin. Arkin and his team have developed an “adaptor” that makes the genetic engineering of microbial components substantially easier and more predictable by converting regulators of translation into regulators of transcription in Escherichia coli. Transcription and translation make up the two-step process by which the coded instructions of genes are used to synthesize proteins. (more…)
GAINESVILLE, Fla. — By analyzing the genes of bacteria, University of Florida researchers have moved a step closer to pinpointing how two brain disorders common in small-breed dogs occur.
The researchers found that the bacteria, known as Mycoplasma canis, invade dog’s cells and suppress their immune system responses. (more…)
