*Inhibiting a molecular process cells use to direct proteins to their proper destinations causes more than 90 percent of affected mosquitoes to die within 48 hours of blood feeding, a UA team of biochemists found.*
Mosquitoes die soon after a blood meal if certain protein components are experimentally disrupted, a team of biochemists at the University of Arizona has discovered.
The approach could be used as an additional strategy in the worldwide effort to curb mosquito-borne diseases like dengue fever, yellow fever and malaria. (more…)
A new advance by UCLA biochemists has brought scientists one step closer to developing treatments that could delay the onset of Alzheimer’s disease and prevent the sexual transmission of HIV.
The researchers report that they have designed molecular inhibitors that target specific proteins associated with Alzheimer’s disease and HIV to prevent them from forming amyloid fibers, the elongated chains of interlocking proteins that play a key role in more than two dozen degenerative and often fatal diseases.(more…)
*Cells at the tip of the slime mold’s fruiting body organize into an epithelial layer and secrete proteins as do some animals cells*
The so-called cellular slime mold, a unicellular organism that may transition into a multicellular organism under stress, has just been found to have a tissue structure that was previously thought to exist only in more sophisticated animals. What’s more, two proteins that are needed by the slime mold to form this structure are similar to those that perform the same function in more sophistical animals.
Shortly after an animal embryo forms, it develops a single layer of cells that, shaped like a hollow ball, is empty at its center. Acting as a kind of “man behind the curtain” that directs these cells to organize into this hollow formation are several proteins that help each cell touch its neighbors but keep its top surface exposed to the formation’s empty interior. (more…)
*New results indicate potential to reduce certain greenhouse gas emissions from oceans to atmosphere*
Increasing acidity in the sea’s waters may fundamentally change how nitrogen is cycled in them, say marine scientists who published their findings in this week’s issue of the journal Proceedings of the National Academy of Sciences (PNAS).
Nitrogen is one of the most important nutrients in the oceans. All organisms, from tiny microbes to blue whales, use nitrogen to make proteins and other important compounds.(more…)
*University of Missouri investigators’ discovery sheds light on how plants fight off bacterial infections*
Columbia, MO — Like us, plants rely on an immune system to fight off disease. Proteins that scout out malicious bacterial invaders in the cell and communicate their presence to the nucleus are important weapons in the plant’s disease resistance strategy. Researchers at the University of Missouri recently “tapped” into two proteins’ communications with the nucleus and discovered a previously unknown level of cross talk. The discovery adds important new information about how plant proteins mediate resistance to bacteria that cause disease and may ultimately lead to novel strategies for boosting a plant’s immune system.
Special proteins in the plant, called resistance proteins, can recognize highly specific features of proteins from pathogen, called effector proteins. When a pathogen is detected, a resistance protein triggers an “alarm” that communicates the danger to the cell’s nucleus. The communication between the resistance protein and nucleus occurs through a mechanism called a signaling pathway. (more…)
A model representation of telomerase's RNA "core domain," determined by Juli Feigon, Qi Zhang and colleagues in Feigon's UCLA laboratory. Image credit: Juli Feigon, UCLA Chemistry and Biochemistry/PNAS
Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.
But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell.
UCLA biochemists have now produced a three-dimensional structural model of the RNA “core domain” of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say.(more…)
*Petunias show that the mechanisms behind inbreeding prevention are similar to immune response*
About the image: The female part of the petunia flower secretes an enzyme that is designed to deter pollen tube growth, thereby preventing fertilization. However, in the cases that the pollen has come from a genetically different plant, the pollen produces its own protein that combats the pistil’s enzyme. With the enzyme out of the way, the pollen tube can keep growing and fertilization can occur. Image credit: Zina Deretsky, National Science Foundation
Inbreeding is a bad strategy for any organism, producing weak and problematic offspring. So imagine the challenge of inbreeding prevention in a plant where male and female sexual organs grow right next to each other! Such is the genetic conundrum faced by the petunia. (more…)
