Tag Archives: protein

Pistil leads pollen in life-and-death dance

By Guest PostJuly 17, 2013Nature, Sciencealexander leydon, biomolecular tango, brown university, cross breeding, female ovule, fertilization, flowers, karolina woroniecka, kristin beale, life on earth, male pollen tube, mark johnson, pistil, pollination, protein, reproduce, reproductive system, sex lives, sperm carrying pollen, stigma, thionin

Pollination, essential to much of life on earth, requires the explosive death of the male pollen tube in the female ovule. In new research, Brown University scientists describe the genetic and regulatory factors that compel the male’s role in the process. Finding a way to tweak that performance could expand crop cross-breeding possibilities.

PROVIDENCE, R.I. [Brown University] — Millions of times on a spring day there is a dramatic biomolecular tango where the flower, rather than adorning a dancer’s teeth, is the performer. In this dance, the female pistil leads, the male pollen tubes follow, and at the finish, the tubes explode and die. A new paper in Current Biology describes the genetically prescribed dance steps of the pollen tube and how their expression destines the tube for self-sacrifice, allowing flowering plants to reproduce. (more…)

Bold Move Forward in Molecular Analyses

By Guest PostMay 21, 2013Scienceabsolute scale, berkeley lab, cell biology, concentration, control, data collection, dataset, john tainer, macromolecules, molecular analyses, molecular machines, nanoparticle, neutrons, protein, robert rambo, sans, sas, sas analysis, sas based statistic, saxs, small angle scattering, solution, structural state, volume of correlation

Berkeley Lab Researchers Develop New Metrics for X-ray and Neutron Analysis of Flexible Macromolecules

A dramatic leap forward in the ability of scientists to study the structural states of macromolecules such as proteins and nanoparticles in solution has been achieved by a pair of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). The researchers have developed a new set of metrics for analyzing data acquired via small angle scattering (SAS) experiments with X-rays (SAXS) or neutrons (SANS). Among other advantages, this will reduce the time required to collect data by up to 20 times.

“SAS is the only technique that provides a complete snapshot of the thermodynamic state of macromolecules in a single image,” says Robert Rambo, a scientist with Berkeley Lab’s Physical Biosciences Division, who developed the new SAS metrics along with John Tainer of Berkeley Lab’s Life Sciences Division and the Scripps Research Institute. (more…)

One-two punch could be key in treating blindness

By Guest PostMay 1, 2013Scienceachromatopsia, andras komaromy, blindness, central nervous system, cntf, fido, humans, michigan state university, model disease, molecular therapy, most younger dogs, photoreceptors, protein, treatment, university of miami, veterinary ophthalmologist

Researchers have discovered that using two kinds of therapy in tandem may be a knockout combo against inherited disorders that cause blindness. While their study focused on man’s best friend, the treatment could help restore vision in people, too.

Published in the journal Molecular Therapy, the study builds on earlier work by Michigan State University veterinary ophthalmologist András Komáromy and colleagues. In 2010, they restored day vision in dogs suffering from achromatopsia, an inherited form of total color blindness, by replacing the mutant gene associated with the condition. (more…)

A new approach to spinal muscular atrophy?

By Guest PostMay 1, 2013Healthals drug, amyotrophic lateral sclerosis, anne hart, boston, brown university, caenorhabditis elegans worm, children hospital, doctors for riluzole, maria dimitriadi, model of sma, neuromuscular disease, new therapy, normal cells, protein, riluzole, sk2 channels, sk2 potassium channels, sma treatment, smn, spinal muscular atrophy, survival motor neuron, united states, worm neurons

Spinal muscular atrophy is a debilitating neuromuscular disease that in its most severe form is the leading genetic cause of infant death. By experimenting with an ALS drug in two very different animal models, researchers at Brown University and Boston Children’s Hospital have identified a new potential mechanism for developing an SMA treatment.

PROVIDENCE, R.I. [Brown University] — There is no specific drug to treat spinal muscular atrophy (SMA), a family of motor neuron diseases that in its most severe form is the leading genetic cause of infant death in the United States and affects one in 6,000 people overall. But a new multispecies study involving a drug that treats amyotrophic lateral sclerosis (ALS) has pinpointed a mechanism of SMA that drug developers might be able to exploit for a new therapy. (more…)

Study Shows How Vitamin E Can Help Prevent Cancer

By Guest PostMarch 30, 2013Healthakt, anti cancer effect, anti cancer property, cancer cell survival, cancer prevention, chemical analysis, ching shih chen, enzyme, formulation, gujarat, hao chieh chiu, India, mutation, naval kapuriya, optimize, phlpp1, prevent cancer, protein, pten gene, saurashtra university, tocopherols, treatment, tumor cell death, vitamin e

COLUMBUS, Ohio – Researchers have identified an elusive anti-cancer property of vitamin E that has long been presumed to exist, but difficult to find.

Many animal studies have suggested that vitamin E could prevent cancer, but human clinical trials following up on those findings have not shown the same benefits. (more…)

Zinc Helps against Infection by Tapping Brakes in Immune Response

By Guest PostFebruary 13, 2013Healthaction, against infection, andrew rudawsky, animal studies, beans, bug, cell culture, charlie pyle, collateral damage, dairy products, daren knoell, excessive inflammation, fortified cereals, human monocytes, ikkb, immune response, inflammatory pathway, invading pathogen, key cells, mark wewers, ming jie liu, nf kb pathway, nuts, ohio state university, protein, shengying bao, some shellfish, sustain human life, tapping brakes, toxic levels, united states, vulnerability to infection, whole grains, zinc, zinc deficiency, zinc deficient mice, zinc supplementation, zinc transporter, zip8

COLUMBUS, Ohio – New research suggests that zinc helps control infections by gently tapping the brakes on the immune response in a way that prevents out-of-control inflammation that can be damaging and even deadly.

Scientists determined in human cell culture and animal studies that a protein lures zinc into key cells that are first-responders against infection. The zinc then interacts with a process that is vital to the fight against infection and by doing so helps balance the immune response. (more…)

Right Target, but Missing the Bulls-Eye for Alzheimer’s

By Guest PostFebruary 3, 2013Health, Scienceabeta, abeta40, abeta42, abeta42 protein, aleksey lomakin, alzheimer's disease, america, amino acids, amyloid beta, atul deshpande, brain, bulls eye, causes of death, chemical synthesis, computer simulations, david teplow, destroy neurons, disorder, george b benedek, gregory cole, hairpin like structure, late life dementia, mingfeng yang, molecular biology, mutant abeta peptides, pearl necklace, plaques, protein, robin roychaudhuri, sally frautschy, sequence, toxic actions, toxic form, ucla

UCLA researchers discover new point of attack for drug therapy

Alzheimer’s disease is the most common cause of late-life dementia. The disorder is thought to be caused by a protein known as amyloid-beta, or Abeta, which clumps together in the brain, forming plaques that are thought to destroy neurons. This destruction starts early, too, and can presage clinical signs of the disease by up to 20 years.

For decades now, researchers have been trying, with limited success, to develop drugs that prevent this clumping. Such drugs require a “target” — a structure they can bind to, thereby preventing the toxic actions of Abeta. (more…)

UCLA Study First to Image Concussion-Related Abnormal Brain Proteins in Retired NFL Players

By Guest PostJanuary 24, 2013Healthabnormal gait, abnormal tau proteins, alzheimer's disease, american journal, amyloid beta plaques, athletes, autopsy, body mass index, brain imaging tool, brain injury, brain pathology, centers, chemical marker, chronic traumatic encephalopathy, clinical assessment, cognitive, cognitive ability, confusion, cte, degenerative condition, degree of depression, dementia, depression, disease control, early detection, early symptoms, family history, fddnp, fran, gary small, gauge, geriatric psychiatry, hallmarks of alzheimers, ham d, hamilton rating scale, intravenous injections, jorge r barrio, julian bailes, linda m ercoli, memory loss, mental state examination, mild, mini, mmse, mood symptoms, national football league, neurofibrillary tau tangles, personality changes, PET, player, positron emission tomography, prabha siddarth, prevention, progression in cte, progressive dementia, protein, ray stark foundation, repair damage, risk, sports related concussions, suicidal behavior, traumatic brain injuries, traumatic brain injury, tremors, vladimir kepe, wayne clark

Technique may lead to earlier diagnosis, tracking of brain disorders in athletes

Sports-related concussions and mild traumatic brain injuries have grabbed headlines in recent months, as the long-term damage they can cause becomes increasingly evident among both current and former athletes. The Centers for Disease Control and Prevention estimates that millions of these injuries occur each year.

Despite the devastating consequences of traumatic brain injury and the large number of athletes playing contact sports who are at risk, no method has been developed for early detection or tracking of the brain pathology associated with these injuries. (more…)