Scientists have discovered a physiological chain of events in animal models in which motor neurons and their communication with muscle become disrupted by the mutation that causes spinal muscular atrophy. (more…)
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Brown University researchers may have discovered what’s responsible for discrepant findings between dozens of fundamental studies of the biology of aging. A drug commonly used in research with C. elegans worms, they report, has had unanticipated effects on lifespan. (more…)
Spinal muscular atrophy is a debilitating neuromuscular disease that in its most severe form is the leading genetic cause of infant death. By experimenting with an ALS drug in two very different animal models, researchers at Brown University and Boston Children’s Hospital have identified a new potential mechanism for developing an SMA treatment.
PROVIDENCE, R.I. [Brown University] — There is no specific drug to treat spinal muscular atrophy (SMA), a family of motor neuron diseases that in its most severe form is the leading genetic cause of infant death in the United States and affects one in 6,000 people overall. But a new multispecies study involving a drug that treats amyotrophic lateral sclerosis (ALS) has pinpointed a mechanism of SMA that drug developers might be able to exploit for a new therapy. (more…)