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Subconscious mental categories help brain sort through everyday experiences

By Guest PostMay 2, 2013Health, Scienceanna schapiro, brain, brown university, chopping vegetables, computational model, dynamic, experiences, functional, magnetic resonance imaging, matthew botvinick, michael frank, natalia cordova, nature neuroscience, neural populations, nicholas turk browne, princeton university, similarity structure, subconscious mental, temporal relationship, timothy rogers

Your brain knows it’s time to cook when the stove is on, and the food and pots are out. When you rush away to calm a crying child, though, cooking is over and it’s time to be a parent. Your brain processes and responds to these occurrences as distinct, unrelated events.

But it remains unclear exactly how the brain breaks such experiences into “events,” or the related groups that help us mentally organize the day’s many situations. A dominant concept of event-perception known as prediction error says that our brain draws a line between the end of one event and the start of another when things take an unexpected turn (such as a suddenly distraught child). (more…)

Sleep consolidates memories for competing tasks

By Guest PostMarch 24, 2013Nature, Scienceavian, brain, brain function, consolidate learning, daniel margoliash, development in birds, excellent model, formation, howard nusbaum, mammalian brains, sleep, stable memories, starlings, timothy brawn, university of chicago

Sleep plays an important role in the brain’s ability to consolidate learning when two new potentially competing tasks are learned in the same day, research at the University of Chicago demonstrates.

Other studies have shown that sleep consolidates learning for a new task. The new study, which measured starlings’ ability to recognize new songs, shows that learning a second task can undermine the performance of a previously learned task. But this study is the first to show that a good night’s sleep helps the brain retain both new memories. (more…)

Green Tea Extract Interferes with the Formation of Amyloid Plaques in Alzheimer’s Disease

By Guest PostMarch 15, 2013Healthakiko kochi, alaina detoma, alzheimer's disease, ayyalusamy ramamoorthy, benefit, bing ye, brain, brandon ruotoloa, copper, egcg, epigallocatechin 3 gallate, green tea, iron, jung suk choi, life sciences institute, metal associated amyloids, mi hee lim, molecule, neurodegenerative conditions, powerful antioxidants, sanghyun lee, specific proteins, structure centric, subramanian vivekanandan, suk joon hyung, tweak, university of michigan, zinc

ANN ARBOR — Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain.

The aggregation of these proteins, called metal-associated amyloids, is associated with Alzheimer’s disease and other neurodegenerative conditions. (more…)

Ancient Lamprey DNA Decoded

By Guest PostMarch 6, 2013Environment, Natureadaptive immune system, ancient lamprey dna, backbones, brain, bygone eras, cambrian period, canadian government, chu yin yeh, chung davidson, data, decode, evolution, fossil records, great lakes, invasive species, jeramiah smith, kaben nanlohy, michigan state university, modern era, modern humans, multicelled creatures, nature genetics, nervous system, pathways, prehistoric species, salmon, scot libants, sea lamprey genome, single celled organisms, spinal cords, spine, titus brown, trout, US, vertebrates, weiming li, yu wen

When it comes to evolution, humans can learn a thing or two from primeval sea lampreys.

In the current issue of Nature Genetics, a team of scientists has presented an assembly of the sea lamprey genome – the first time the entire sequence has been decoded. The data is compelling as the sea lamprey is one of the few ancient, jawless species that has survived through the modern era.

The paper not only sheds light on how the venerable invasive species adapted and thrived, but it also provides many insights into the evolution of all vertebrates, species with backbones and spinal cords, which includes humans, said Weiming Li, Michigan State University fisheries and wildlife professor, who organized and coordinated the team. (more…)

Songbirds’ Brains Coordinate Singing with Intricate Timing, Study Shows

By Guest PostMarch 2, 2013Nature, Scienceactivity, ana amador, anatomy, aphasia, avian vocal organ, basic motor functions, brain, buenos aires, control vocalizations, coordinate singing, coordinating human speech, daniel margoliash, disorder, dynamics of movement, feedback, gabriel mindlin, highly skilled behavior, howard nusbaum, human brain, human speech production, model, neuroscientist, premotor cortical neurons, single neurons, song, song system, songbird, songs of birds, speech, speech problems, stroke, stuttering, syrinx, timing, university, university of chicago, vocal signals, yonatan sanz perl, zebra finches

Research may help explain how human brain governs speech

As a bird sings, some neurons in its brain prepare to make the next sounds while others are synchronized with the current notes—a coordination of physical actions and brain activity that is needed to produce complex movements, new research at the University of Chicago shows.

In an article in the current issue of Nature, neuroscientist Daniel Margoliash and colleagues show, for the first time, how the brain is organized to govern skilled performance—a finding that may lead to new ways of understanding human speech production. (more…)

Vitamin D, Omega-3 May Help Clear Amyloid Plaques Found in Alzheimer’s

By Guest PostFebruary 12, 2013Healthalzheimer, amyloid beta, amyloid beta absorption, amyloid plaques, avi siani, blood samples, brain, cell death, critical immune cells, dihydroxyvitamin d3, docosahexaenoic acid, eicosapentaenoic acid, fatty acid dha, fatty acid epa, fatty acids, guanghao liu, immune system, improve plaque clearance, inflammation, inflammatory genes, james sayre, larry magpantay, macrophages, mathew mizwicki, milan fiala, nutrition molecule, omega 3 dha, omega-3, oxidation, vitamin D, vitamin d3

A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system’s ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer’s disease.

In a small pilot study published in the Feb. 5 issue of the Journal of Alzheimer’s Disease, the scientists identified key genes and signaling networks regulated by vitamin D3 and the omega-3 fatty acid DHA (docosahexaenoic acid) that may help control inflammation and improve plaque clearance. (more…)

Right Target, but Missing the Bulls-Eye for Alzheimer’s

By Guest PostFebruary 3, 2013Health, Scienceabeta, abeta40, abeta42, abeta42 protein, aleksey lomakin, alzheimer's disease, america, amino acids, amyloid beta, atul deshpande, brain, bulls eye, causes of death, chemical synthesis, computer simulations, david teplow, destroy neurons, disorder, george b benedek, gregory cole, hairpin like structure, late life dementia, mingfeng yang, molecular biology, mutant abeta peptides, pearl necklace, plaques, protein, robin roychaudhuri, sally frautschy, sequence, toxic actions, toxic form, ucla

UCLA researchers discover new point of attack for drug therapy

Alzheimer’s disease is the most common cause of late-life dementia. The disorder is thought to be caused by a protein known as amyloid-beta, or Abeta, which clumps together in the brain, forming plaques that are thought to destroy neurons. This destruction starts early, too, and can presage clinical signs of the disease by up to 20 years.

For decades now, researchers have been trying, with limited success, to develop drugs that prevent this clumping. Such drugs require a “target” — a structure they can bind to, thereby preventing the toxic actions of Abeta. (more…)

Researchers Create Flexible, Nanoscale ‘Bed of Nails’ for Possible Drug Delivery

By Guest PostJanuary 27, 2013Sciencealuminum substrate, anatoli melechko, balloon, bed of nails, brain, bryan anderson, carbon nanofibers, drug delivery systems, elastic membrane, elastic silicone membrane, embedding carbon nanofibers, joseph tracy, justin railsback, liquid silicone polymer, mehmet sarac, nanofibers, nanoscale, needle like, north Carolina, ryan pearce, state university, technique, timothy mcknight

Researchers at North Carolina State University have come up with a technique to embed needle-like carbon nanofibers in an elastic membrane, creating a flexible “bed of nails” on the nanoscale that opens the door to development of new drug-delivery systems.

The research community is interested in finding new ways to deliver precise doses of drugs to specific targets, such as regions of the brain. One idea is to create balloons embedded with nanoscale spikes that are coated with the relevant drug. Theoretically, the deflated balloon could be inserted into the target area and then inflated, allowing the spikes on the balloon’s surface to pierce the surrounding cell walls and deliver the drug. The balloon could then be deflated and withdrawn. (more…)

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