Tag Archives: medicine

Human Cognition Depends Upon Slow-Firing Neurons

Good mental health and clear thinking depend upon our ability to store and manipulate thoughts on a sort of “mental sketch pad.” In a new study, Yale School of Medicine researchers describe the molecular basis of this ability — the hallmark of human cognition — and describe how a breakdown of the system contributes to diseases such as schizophrenia and Alzheimer’s disease.

“Insults to these highly evolved cortical circuits impair the ability to create and maintain our mental representations of the world, which is the basis of higher cognition,” said Amy Arnsten, professor of neurobiology and senior author of the paper published in the Feb. 20 issue of the journal Neuron. (more…)

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Costly Breast Cancer Screenings Don’t Add up to Better Outcomes

Even though Medicare spends over $1 billion per year on breast cancer screenings such as a mammography, there is no evidence that higher spending benefits older women, researchers at Yale School of Medicine found in a study published Online First by JAMA Internal Medicine, a JAMA Network publication.

Led by Dr. Cary Gross, associate professor of internal medicine at Yale School of Medicine and director of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, the study sought to provide a comprehensive understanding of breast cancer expenditures that incorporate the cost of screening and associated work-up, as well as treatment. They assessed overall national costs, as well as variation in costs across geographic regions. (more…)

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Biodiversity: The most common issues

Biodiversity can be considered as an imperative factor that plays a crucial role in poverty reduction owing to its basic goods and the ecosystem services it provides. Over three billion people rely on coastal and marine biodiversity and about 1.7 billion people depend upon non-timber forest products and forests for biodiversity.

Common issues relating to biodiversity can be classified as:

Biodiversity as a source of income and food

World’s poor population, especially living in rural areas are dependent on biological resources for meeting most of their needs. At least, 90 percent of their needs relating to fuel, shelter, medicines and food come from biological resources. (more…)

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Battling Tuberculosis through Microsoft Technology

Microsoft Research develops biometric monitoring system to help patients complete tuberculosis treatment programs.

BANGALORE, India — Dec. 3, 2012 — Giri Prasad, a 33-year-old tailor who lives in Delhi, first noticed the pain below his ribs. He went to see a doctor, but when it didn’t subside, he traveled to the hospital where he eventually learned he had tuberculosis.

“There were many problems because first and foremost, I am the bread earner for the family,” he says. “If the bread earner falls ill, it is a real problem for those who are dependent on him. Here in the city the biggest problem is that if one falls sick, there is no other person who will come help.” (more…)

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First Digital Resource Explores 1918 Flu Epidemic

ANN ARBOR — The University of Michigan has established the largest digital collection of materials relating to the 1918 influenza epidemic in the United States.

“The American Influenza Epidemic of 1918: A Digital Encyclopedia,” created by the Center for the History of Medicine in partnership with the U-M Library’s MPublishing, documents 50 diverse communities in the United States during fall 1918 and winter 1919—a period when the effects of influenza caused the deaths of an estimated 650,000 Americans (and 50 million people worldwide). (more…)

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Latest JBEI Startup to Speed Up Biotech Industry

TeselaGen’s DNA construction technology makes genetic engineering cheaper and faster.

Sequencing, splicing and expressing DNA may seem to be the quintessence of cutting-edge science—indeed DNA manipulation has revolutionized fields such as biofuels, chemicals and medicine. But in fact, the actual process can still be tedious and labor-intensive, something Lawrence Berkeley National Laboratory (Berkeley Lab) scientist Nathan Hillson learned the hard way.

After struggling for two days to design a protocol to put together a genetic circuit with 10 pieces of DNA—using a spreadsheet as his primary tool—he was dismayed to discover that an outside company could have done the whole thing, including parts and labor, for lower cost than him ordering the oligonucleotides himself. “I learned two things: one, I never wanted to go through that process again, and two, it’s extremely important to do the cost-effectiveness calculation,” said Hillson, a biochemist who also directs the synthetic biology program at the Berkeley Lab-led Joint BioEnergy Institute (JBEI). “So that was the genesis of the j5 software. This is the perfect thing to teach a computer to do.” (more…)

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Teens Who Smoke and Drink May be More Likely to Abuse Prescription Opioids Later

Adolescents who smoke cigarettes or use alcohol or marijuana may be at greater risk for subsequent abuse of prescription opioids as young adults, according to a new study by Yale School of Medicine.

The researchers believe their findings are the first to demonstrate that early alcohol, cigarette, and marijuana use are all associated, to varying degrees, with a two- to-three times greater likelihood of subsequent abuse of prescription opioids. The study appears online in the Journal of Adolescent Health. (more…)

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Building Molecular ‘Cages’ to Fight Disease

UCLA-created nanoscale protein containers could aid drug, vaccine delivery

UCLA biochemists have designed specialized proteins that assemble themselves to form tiny molecular cages hundreds of times smaller than a single cell. The creation of these miniature structures may be the first step toward developing new methods of drug delivery or even designing artificial vaccines.

“This is the first decisive demonstration of an approach that can be used to combine protein molecules together to create a whole array of nanoscale materials,” said Todd Yeates, a UCLA professor of chemistry and biochemistry and a member of the UCLA–DOE Institute of Genomics and Proteomics and the California NanoSystems Institute at UCLA. (more…)

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