Tag Archives: medicine

Costly Breast Cancer Screenings Don’t Add up to Better Outcomes

By Guest PostJanuary 22, 2013Healthanees chagpar, breast cancer, breast cancer incidence, brigid killelea, cary gross, copper team, cost of screening, geographic regions, heather gold, jama network publication, jessica long, joseph ross, mammography, maysa abu khalaf, medicine, rong wang, screenings, treatment, united states, variation, xiaomei ma, yale cancer center, yale school

Even though Medicare spends over $1 billion per year on breast cancer screenings such as a mammography, there is no evidence that higher spending benefits older women, researchers at Yale School of Medicine found in a study published Online First by JAMA Internal Medicine, a JAMA Network publication.

Led by Dr. Cary Gross, associate professor of internal medicine at Yale School of Medicine and director of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, the study sought to provide a comprehensive understanding of breast cancer expenditures that incorporate the cost of screening and associated work-up, as well as treatment. They assessed overall national costs, as well as variation in costs across geographic regions. (more…)

Biodiversity: The most common issues

By Guest PostJanuary 5, 2013Environmentbiodiversity, biodiversity management, biological resources, coastal, common issues, ecological loss, ecosystem service, edward o wilson, evolutionary biologist, extinction, food, fuel, grassland, human interference, imperative factor, key issue, lincoln navigator suv, luxury cars, marine biodiversity, medicine, Nature, nutrient cycle, pacific northwest, poverty, rural area, shelter, soil formation, spotted owl, tropical forest

Biodiversity can be considered as an imperative factor that plays a crucial role in poverty reduction owing to its basic goods and the ecosystem services it provides. Over three billion people rely on coastal and marine biodiversity and about 1.7 billion people depend upon non-timber forest products and forests for biodiversity.

Common issues relating to biodiversity can be classified as:

Biodiversity as a source of income and food

World’s poor population, especially living in rural areas are dependent on biological resources for meeting most of their needs. At least, 90 percent of their needs relating to fuel, shelter, medicines and food come from biological resources. (more…)

Battling Tuberculosis through Microsoft Technology

By Guest PostDecember 3, 2012Health, Technologyaakar gupta, abhishek sinha, aids, anti viral drugs, bacille calmette guerin, bacteria, bangalore, battling tuberculosis, bcg, bill thies, biometric monitoring system, computer, fingerprint, giri prasad, great killer, gsm modem, hiv, mdr tb, medicine, michal paik, microsoft research india, microsoft technology, multidrug resistant tuberculosis, navkar samdaria, nupur bhatnagar, operation asha, shelly batra, software, sql server database, tb, treatment, tuberculosis, uganda health ministry, vaccine

Microsoft Research develops biometric monitoring system to help patients complete tuberculosis treatment programs.

BANGALORE, India — Dec. 3, 2012 — Giri Prasad, a 33-year-old tailor who lives in Delhi, first noticed the pain below his ribs. He went to see a doctor, but when it didn’t subside, he traveled to the hospital where he eventually learned he had tuberculosis.

“There were many problems because first and foremost, I am the bread earner for the family,” he says. “If the bread earner falls ill, it is a real problem for those who are dependent on him. Here in the city the biggest problem is that if one falls sick, there is no other person who will come help.” (more…)

Latest JBEI Startup to Speed Up Biotech Industry

By Guest PostOctober 3, 2012Scienceautocad, berkeley lab, biofuels, biology, chemicals, cutting edge, design, DNA, dna manipulation, eduardo abeliuk, electrical engineering, expressing, inertia, iso27001, j5 software, jbei, majed abolfazli, medicine, metabolic pathway, mike fero, modern cloning, molecular biology, nathan hillson, organism, pharmchem, protocol, qb3, san francisco, Science, sequencing, splicing, stanford university, teselagen

TeselaGen’s DNA construction technology makes genetic engineering cheaper and faster.

Sequencing, splicing and expressing DNA may seem to be the quintessence of cutting-edge science—indeed DNA manipulation has revolutionized fields such as biofuels, chemicals and medicine. But in fact, the actual process can still be tedious and labor-intensive, something Lawrence Berkeley National Laboratory (Berkeley Lab) scientist Nathan Hillson learned the hard way.

After struggling for two days to design a protocol to put together a genetic circuit with 10 pieces of DNA—using a spreadsheet as his primary tool—he was dismayed to discover that an outside company could have done the whole thing, including parts and labor, for lower cost than him ordering the oligonucleotides himself. “I learned two things: one, I never wanted to go through that process again, and two, it’s extremely important to do the cost-effectiveness calculation,” said Hillson, a biochemist who also directs the synthetic biology program at the Berkeley Lab-led Joint BioEnergy Institute (JBEI). “So that was the genesis of the j5 software. This is the perfect thing to teach a computer to do.” (more…)

Teens Who Smoke and Drink May be More Likely to Abuse Prescription Opioids Later

By Guest PostAugust 27, 2012Culture, Healthabuse, adolescents, alcohol, cigarette, david fiellin, drink, drug use, gateway hypothesis, jeanette tetrault, lynn fiellin, marijuana, medicine, national survey, opioid abuse, prescription opioids, rani hoff, smoke, teens, william becker, yale school, young men, young women

Adolescents who smoke cigarettes or use alcohol or marijuana may be at greater risk for subsequent abuse of prescription opioids as young adults, according to a new study by Yale School of Medicine.

The researchers believe their findings are the first to demonstrate that early alcohol, cigarette, and marijuana use are all associated, to varying degrees, with a two- to-three times greater likelihood of subsequent abuse of prescription opioids. The study appears online in the Journal of Adolescent Health. (more…)

Building Molecular ‘Cages’ to Fight Disease

By Guest PostJune 9, 2012Scienceartificial vaccines, bioinformatics, biomedical engineering, building blocks, circulation, david baker, drug, drug delivery, duilio cascio, human like proteins, lego blocks, medicine, michael sawaya, molecular biology, molecular cages, molecular structure, nanoscale materials, neil king, puzzle pieces, specialized proteins, tangles of ribbon, three-dimensional, tiny structures, todd yeates, traditional vaccine, tumor cells, ucla, university of washington, virus derived proteins, yen ting lai

UCLA-created nanoscale protein containers could aid drug, vaccine delivery

UCLA biochemists have designed specialized proteins that assemble themselves to form tiny molecular cages hundreds of times smaller than a single cell. The creation of these miniature structures may be the first step toward developing new methods of drug delivery or even designing artificial vaccines.

“This is the first decisive demonstration of an approach that can be used to combine protein molecules together to create a whole array of nanoscale materials,” said Todd Yeates, a UCLA professor of chemistry and biochemistry and a member of the UCLA–DOE Institute of Genomics and Proteomics and the California NanoSystems Institute at UCLA. (more…)

New Twist on Ancient Math Problem Could Improve Medicine, Microelectronics

By Guest PostMay 15, 2012Scienceancient math problem, carolyn phillips, filling problem, hidden facet, medicine, microelectronics, microprocessor, Nanotechnology, pentagon, protein, radiation beam, sanskrit manuscript, sharon glotzer, silicon chip, solution, starfish, three dimensions, traps, treating tumor, two dimensions, university of connecticut, university of michigan

ANN ARBOR, Mich.— A hidden facet of a math problem that goes back to timeworn Sanskrit manuscripts has just been exposed by nanotechnology researchers at the University of Michigan and the University of Connecticut.

It turns out we’ve been missing a version of the famous “packing problem,” and its new guise could have implications for cancer treatment, secure wireless networks, microelectronics and demolitions, the researchers say.

Called the “filling problem,” it seeks the best way to cover the inside of an object with a particular shape, such as filling a triangle with discs of varying sizes. Unlike the traditional packing problem, the discs can overlap. It also differs from the “covering problem” because the discs can’t extend beyond the triangle’s boundaries. (more…)

New 3-D Model of RNA ‘Core Domain’ of Enzyme Telomerase May Offer Clues to Cancer, Aging

By Guest PostNovember 6, 2010Health, Scienceaging, cancer, cells, chromosomes, DNA, dna damage, enzyme, helical extension, juli feigon, medicine, nmr, nobel prize, nuclear magnetic resonance, physiology, proteins, pseudoknot, qi zhang, rna, spectroscopy, telomerase, telomeres, virus

A model representation of telomerase's RNA "core domain," determined by Juli Feigon, Qi Zhang and colleagues in Feigon's UCLA laboratory. Image credit: Juli Feigon, UCLA Chemistry and Biochemistry/PNAS

Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.

But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell.

UCLA biochemists have now produced a three-dimensional structural model of the RNA “core domain” of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say. (more…)