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A promising step toward controlling Zika virus and dengue fever

UCLA scientists and colleagues identify structure of a molecule that kills mosquitoes carrying malaria and West Nile

Five UCLA researchers were part of an international team that has used X-rays to reveal the structure of a molecule that is toxic to disease-carrying mosquitoes. The findings move the scientific world one step closer to genetically engineering a toxin that would be lethal to species that carry dengue fever and the Zika virus. (more…)

Building Molecular ‘Cages’ to Fight Disease

By Guest PostJune 9, 2012Scienceartificial vaccines, bioinformatics, biomedical engineering, building blocks, circulation, david baker, drug, drug delivery, duilio cascio, human like proteins, lego blocks, medicine, michael sawaya, molecular biology, molecular cages, molecular structure, nanoscale materials, neil king, puzzle pieces, specialized proteins, tangles of ribbon, three-dimensional, tiny structures, todd yeates, traditional vaccine, tumor cells, ucla, university of washington, virus derived proteins, yen ting lai

UCLA-created nanoscale protein containers could aid drug, vaccine delivery

UCLA biochemists have designed specialized proteins that assemble themselves to form tiny molecular cages hundreds of times smaller than a single cell. The creation of these miniature structures may be the first step toward developing new methods of drug delivery or even designing artificial vaccines.

“This is the first decisive demonstration of an approach that can be used to combine protein molecules together to create a whole array of nanoscale materials,” said Todd Yeates, a UCLA professor of chemistry and biochemistry and a member of the UCLA–DOE Institute of Genomics and Proteomics and the California NanoSystems Institute at UCLA. (more…)

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A promising step toward controlling Zika virus and dengue fever

Building Molecular ‘Cages’ to Fight Disease