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Immune Systems of ‘Bubble Babies’ Restored by Gene Therapy, UCLA Researchers Find

By Guest PostSeptember 14, 2012Healthada deficient, adenosine deaminase, bone marrow, bubble boy, chemotherapy, chronic diarrhea, denise carbonaro sarracino, disease, donald kohn, ear infections, enzyme, gene therapy, immune system, immunology, microbiology, molecular genetics, oral candidiasis, recurrent pneumonia, researcher, scid, stem cell, sterile environment, treatment, ucla, virus

UCLA stem cell researchers have found that a gene therapy regimen can safely restore immune systems to children with so-called “bubble boy” disease, a life-threatening condition that if left untreated can be fatal within one to two years.

In the 11-year study, researchers were able to test two therapy regimens for 10 children with ADA-deficient severe combined immunodeficiency (SCID), which has come to be known as “bubble boy” disease because some of its victims have been forced to live in sterile environments. (more…)

Study: Heart Damage after Chemo Linked to Stress in Cardiac Cells

By Guest PostMay 22, 2012Healthblocking, breast cancer, cancer cell, cardiac damage, cardiomyocytes, cellular level, chemotherapy, doxorubicin, drug, gene, govindasamy ilangovan, heart, heart muscle cells, heat shock factor 1, hsf 1, karthikeyan krishnamurthy, kaushik vedam, mdr1, multidrug resistance 1, nf kb, ohio state university, protein, ragu kanagasabai

COLUMBUS, Ohio – Blocking a protein in the heart that is produced under stressful conditions could be a strategy to prevent cardiac damage that results from chemotherapy, a new study suggests.

Previous research has suggested that up to a quarter of patients who receive the common chemotherapy drug doxorubicin are at risk of developing heart failure later in life. Exactly how that heart damage is done remains unclear.

In this study, scientists identified a protein called heat shock factor-1 (HSF-1) as a likely source of chemotherapy-related heart damage in mice and cell cultures. Heat shock factor-1 is known to be induced by stress – in this case, the chemotherapy treatment itself. (more…)

Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

By Guest PostFebruary 19, 2012Healthbreast cancer, cancer cell, chemotherapy, dna damage, frank pajonk, ibcsc, induced pluripotent stem cells, ips, kim irwin, oncologist, radiation therapy, radiation treatment, regenerative medicine, stem cell, tumor, tumor recurrence

Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)

Targeting Protein Critical To Cell Division Stops Cancer Cells From Proliferating And Kills Them

By Guest PostDecember 18, 2011Scienceanti cancer therapies, apoptosis, biology and metabolism, cancers, cell death, cell division, chemotherapy, chromosome transmission, combination therapy, computational analyses, daughter cells, DNA, drug taxol, dynamic structure, formation of a tumor, function, genetic screen, jorge torres, kinesin like protein, malignant cells, mitosis, mitotic spindle, molecular motor, normal cells, novel strategy, protein, spindle function, stard9, toxic

Suppressing a newly identified protein involved in regulating cell division could be a novel strategy for fighting certain cancers because it stops the malignant cells from dividing and causes them to die quickly, according to a study by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

During the five-year study, designed to seek new targets for anti-cancer therapies, researchers discovered that depleting the protein, called STARD9, also helped the commonly used chemotherapy drug Taxol work more effectively against certain cancers. (more…)

Researcher Aims to Improve Effectiveness of Radiation Therapy for Cancer

By Guest PostMarch 7, 20112 commentsHealth, Scienceanticancer drugs, biology of tumor cells, cancer therapy, cancer treatment, characterize the tumors, chemotherapy, ct, diabetes, heart attacks, hypoxia, hypoxia induced pathways, hypoxic cells, localiz, malignant cells, methods for imaging tumors, microscopic tumors, mri, oxygen deficiency, oxygen deficiency in tissues, PET, pharmacology, radiation, sara rockwell, stroke, therapeutic radiology, yale

Sara Rockwell is a leader in her field. A professor of therapeutic radiology and pharmacology at the School of Medicine, Rockwell was among the first researchers to study the effects of oxygen deficiency on the response of malignant cells to radiation and anticancer drugs, and was among the first to consider the implications of this deficiency in microscopic tumors for the development of solid malignancies.

Rockwell, who is also associate dean for scientific affairs, joined the faculty of Yale School of Medicine in 1974, and teaches radiation biology, pharmacology, cancer biology, ethics and career development skills. She earned her bachelor’s degree in physics from Penn State University in 1965. She went on to earn her doctorate degree in biophysics from Stanford University in 1971. (more…)

Women Fight the Effects of Chemotherapy Long After Treatment Ends, MU Researchers Find

By Guest PostOctober 19, 2010Healthbody-image issues, breast cancer, breast cancer treatment, chemotherapy, depression, mental health, quality of life, rural areas, stephanie reid arndt, symptoms, university of missouri, urban areas, women

COLUMBIA, Mo. – For some women, the effects of breast cancer, the most common cancer affecting women, do not end when they leave the hospital. Now, researchers in the University of Missouri School of Health Professions have studied the lives of breast cancer patients following chemotherapy and found that their environments and available support systems help determine the quality of their lives.

“A lot of times people get mentally and emotionally ready to deal with chemotherapy and they receive a lot of support during that time,” said Stephanie Reid-Arndt, an assistant professor of health psychology in the School of Health Professions. “Then they go home and everyone feels like it’s over, but the patients still have worries and fears about the changes they’ve been through and what it means for the future.” (more…)

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