Tag Archives: bacterium

What Makes Ticks Tick?

By Guest PostMarch 11, 2012Healthanaplasmosis, antibiotic therapy, apple, arthritis, babesiosis, bacterium, climate change, dengue fever, disease, durland fish, european ancestry, evolution, infectious diseases, iPhone, lyme disease, maine, malaria, michigan, minnesota, neurological problems, North America, Pennsylvania, placebo, ticks, united states, virginia, west nile virus, wisconsin

Durland Fish has researched ticks and their associated diseases for decades. A professor in the Division of Epidemiology of Microbial Diseases at the Yale School of Public Health, he has, among other things, contributed to the discovery that the bacterium that causes Lyme disease has European ancestry and that the disease, once nearly eradicated in North America, roared back with reforestation. More recently he helped develop a Lyme disease “app” for the iPhone and other Apple devices that provides users with detailed information about tick populations in any given area in the United States and even comes with a video on how to safely remove a tick. He has also worked on mosquito-borne West Nile virus and dengue fever. Students selected Fish as the school’s mentor of the year in 2010. (more…)

Russian Dolls of the Bug World

By Guest PostMarch 1, 2012Scienceacyrthosiphon pisum, aphid alarm pheromone, aphidius ervi, aphids, apse, bacteriophage, bacterium, battle for survival, environmental sciences, Europe, hamiltonella defense, hemolymph, insect, kerry oliver, martha molly hunter, North America, parasite and host, parasitic wasps, pea aphid, russian dolls, symbiont, trans b farnesene, university of arizona, virus, wasp larva

Parasitic wasps using tiny insects known as aphids as living nurseries for their brood can sniff out whether the host insect is protected by symbiotic bacteria, researchers have discovered.

A research team including Martha (Molly) Hunter from the department of entomology in the University of Arizona’s College of Agriculture of Life Sciences has disentangled relationships in an assembly of players that resemble Russian dolls: a bacterium that lives inside a tiny insect, a virus that infects those bacteria, and a parasitic wasp that lays its eggs in the insect.

In a war between parasite and host, the parasitic wasp, Aphidius ervi, and the pea aphid, Acyrthosiphon pisum, are locked in a battle for survival. (more…)

Studying The Evolution of Life’s Building Blocks

By Guest PostFebruary 20, 2012Sciencealbert szent gyorgyi, ancient life, bacterium, basic module, beginning of life, beginning of time, british columbia, building block, chemical building block, chemical reactions, evolution, evolution of life, geneticists, michigan state university, molecular complementarity, molecular paleontology, origin of life, paleontologists, physiologist, robert root bernstein, species, vancouver, vitamin c

VANCOUVER, British Columbia — Studying the origin of life at its building blocks offers a unique perspective on evolution, says a researcher at Michigan State University.

Robert Root-Bernstein, MSU physiology professor, will answer the question of why a physiologist studies the origin of life at the annual meeting of the American Association for the Advancement of Science Feb. 16-20 in Vancouver, British Columbia. (more…)

New U-M Computer Model Predicts Cholera Outbreaks Up To 11 Months in Advance

By Guest PostJanuary 23, 2012Environment, Scienceaaron king, annual monsoon flooding, attack rates, bacterium, Bangladesh, capital city, cholera cases, cholera outbreaks, climate change, climate factors, climate sensitive urban core, climate variability, computer model, cycles of cholera, dhaka, diarrheal disease, disease transmission, ecology, el niño southern oscillation, enso episode, fecal oral diseases, mercedes pascual, michael emch, mohammad yunus, pathogen, post monsoon, prediction, risk factors, robert reiner, sanitary conditions, space and time, spatial location, university of michigan, urban periphery, vaccination, vibrio cholera, warning system

ANN ARBOR, Mich.— A new University of Michigan computer model of disease transmission in space and time can predict cholera outbreaks in Bangladesh up to 11 months in advance, providing an early warning system that could help public health officials there.

The new forecast model applies specifically to the capital city of Dhaka and incorporates data on both year-to-year climate variability and the spatial location of cholera cases at the district level. This allowed the researchers to study both local variation in disease transmission and response to climate factors within the megacity of 14 million people. (more…)

Scientists Defuse the Vietnam Time Bomb

By Guest PostNovember 11, 2011Health, Sciencebacterial pathogen, bacterium, burkholderia, burkholderia pseudomallei, cancer, david rice, deadly tropical disease, diseases, drugs, endemic areas, esrf, european synchrotron radiation facility, france, grenoble, hiv and tuberculosis, kevin van cauter, key mechanism, melioidosis, northern australia, pmi2 funding, protein synthesis, rick titball, south east asia, structure of a protein, stuart wilson, therapies to prevent the proliferation of cancer cells, university of exeter, university of sheffield, us military personnel, vietnam time bomb, xrays at diamond light source

A key mechanism by which a bacterial pathogen causes the deadly tropical disease melioidosis has been discovered by an international team, including a University of Exeter scientist.

The findings are published in the journal Science and show how a toxin produced by the bacterium Burkholderia pseudomallei kills cells by preventing protein synthesis.

The study, led by the University of Sheffield, paves the way for the development of novel therapies to combat the bacterium which infects millions of people across South East Asia and Northern Australia.

Using intense X-rays at Diamond Light Source, the UK’s national synchrotron facility, and at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France, the research team solved the structure of a protein from Burkholderia, the function of which was initially unknown. (more…)

Smarter Toxins Help Crops Fight Resistant Pests

By Guest PostOctober 11, 2011Scienceb rogers leonard, bacillus thuringiensis, bacterium, beneficial insects, bruce tabashnik, bt, bt cotton, bt toxins, cadherin, cadherin mutations, caterpillars, change in molecular structure, crop protecting proteins, david heckel, fangneng huang, genetic engineering, Germany, jena, lady bugs, manduca sexta, max planck institute for chemical ecology, mukti ghimire, pectinophora gossypiella, pests, pink bollworm, rna interference, tobacco hornworm

*A slight change in molecular structure introduced by genetic engineering gives crop-protecting proteins called Bt toxins a new edge in overcoming resistance of certain pests, a UA-led team of researchers reports in Nature Biotechnology.*

One of the most successful strategies in pest control is to endow crop plants with genes from the bacterium Bacillus thuringiensis, or Bt for short, which code for proteins that kill pests attempting to eat them.

But insect pests are evolving resistance to Bt toxins, which threatens the continued success of this approach. In the current issue of Nature Biotechnology, a research team led by UA Professor Bruce Tabashnik reports the discovery that a small modification of the toxins’ structure overcomes the defenses of some major pests that are resistant to the natural, unmodified Bt toxins. (more…)

Close Up Look at a Microbial Vaccination Program

By Guest PostOctober 3, 2011Health, Sciencebacterium, berkeley lab, blake wiedenheft, casa, casb, case, cells, clustered regularly interspaced short palindromic repea, complex of proteins, crispr, cryo electron microscopy, e coli, escherichia coli, eva nogales, gabriel lander, human pathogens, immune system, infections by bacteria, invading pathogens, jennifer doudna, john van der oost, kaihong zhou, microbe, microbial, microbial immune systems, microbiome, perturbations, protein complex called cascade, seahorse, short interfering rnas, sirnas, symbioses, toxins, unit of dna, viruses

*Berkeley Lab Researchers Resolve Sub-nanometer Structure of Cascade, an Ally for Human Immune System*

A complex of proteins in the bacterium E.coli that plays a critical role in defending the microbe from viruses and other invaders has been discovered to have the shape of a seahorse by researchers with the U.S Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). This discovery holds far more implications for your own health than you might think.

In its never-ending battle to protect you from infections by bacteria, viruses, toxins and other invasive elements, your immune system has an important ally – many allies in fact. By the time you reach adulthood, some 90-percent of the cells in your body are microbial. These microbes – collectively known as the microbiome – play a critical role in preserving the health of their human host. (more…)

A Bug Like a Russian Doll

By Guest PostAugust 20, 2011Scienceanimal metabolism, bacteria, bacterial symbiont, bacterium, carol von dohlen, cytoplasm, dual symbiont systems, human gut, immune system, john mccutcheon, lyle buss, metabolic pathways, moranella, nested symbiosis of mealybugs, relationships between bacteria and citrus mealybugs, relationships between organisms, tremblaya

*A former UA postdoctoral fellow has discovered amazing relationships between organisms: a bacterium living inside a bacterium living inside an insect. Evolving together, the organisms depend on each other for survival, and each contributes a subset of the enzymes needed in shared metabolic pathways.*

Sure, many bacteria cause disease, but most people don’t realize how beneficial they can be. The human gut, for example, brims with bacteria that play critical roles in everything from immune system development and extracting energy from food to providing necessary nutrients.

They get a nice comfy home living inside people, and in return they help us. It’s a symbiotic relationship. However, these beneficial partnerships are nothing compared to the complex relationships between bacteria and citrus mealybugs recently discovered by a team of biologists led by former UA researcher John McCutcheon, who recently took a position as an assistant professor at the University of Montana. (more…)