Discovery could help lead to prevention of radical surgery for rare childhood disease
Hemimegalencephaly is a rare but dramatic condition of infancy in which half the brain is malformed and much larger than the other half. Its cause is unknown, but the current treatment is radical: the surgical disconnection and removal of the diseased half of the brain.
In a paper published in the June 24 online issue of the journal Nature Genetics, a team of doctors and scientists says mutations in a trio of genes that help regulate cell size and proliferation are likely culprits in causing the disorder, though perhaps not the only ones.
These mutations, known as de novo somatic mutations, are genetic changes in the cells of the brain. Because they are in non-sex organs, the mutations are not transmitted to the child by either parent. (more…)
UD’s Schmidt studies genome of crocodile family in evolution research
University of Delaware scientist Carl Schmidt is working to identify genes in crocodiles, alligators and gharials as he searches for links between the creatures that could give clues as to how they evolved over the years in relation to one another.
Schmidt’s effort is part of a National Science Foundation-funded project being conducted by a team of researchers assembled by David Ray, an evolutionary biologist at Mississippi State University. (more…)
Discovery ends UCLA scientist’s 20-year quest for cause of IMAGe syndrome
The Caterpillar got down off the mushroom … remarking as it went, ‘One side will make you grow taller, and the other side will make you grow shorter.’
—Lewis Carroll, “Alice’s Adventures in Wonderland”
UCLA geneticists have identified the mutation responsible for IMAGe syndrome, a rare disorder that stunts infants’ growth. The twist? The mutation occurs on the same gene that causes Beckwith–Wiedemann syndrome, which makes cells grow too fast, leading to very large children.
Published in the May 27 edition of the journal Nature Genetics, the UCLA findings could lead to new ways of blocking the rapid cell division that allows tumors to grow unchecked. The discovery also offers a new tool for diagnosing children with IMAGe syndrome, which until now has been difficult to identify accurately. (more…)
Data Driven Best-in-Class Technology Uncovers Optimal Targeted Audiences at Scale in a Premium Media Ecosystem
NEW YORK — At Internet Week New York, Yahoo!, the premier digital media company, today announces Genome from Yahoo! (www.genomeplatform.com), an online advertising solution that combines Yahoo! data with interclick’s third party data and advertisers’ first party data along with a premium media footprint to provide marketers with the most complete, custom audience solution in the industry. Anticipated to be available in July 2012, Genome is the culmination of a strategy that was put in place last year with the display ad agreement with Microsoft and AOL as well as the acquisition of interclick, which Yahoo! acquired in December 2011, to create a next generation audience buying solution with greater targeting and personalization capabilities.
Genome, designed to leverage data to improve advertiser ROI, can provide marketers with actionable insights enabling them to conduct campaigns that help meet their objectives, and overcome an ever-evolving set of industry challenges that include the proliferation of data, fragmentation of technology, and outdated planning and buying techniques. Genome can help marketers organize and navigate the chaos of the data ecosystem while delivering results that can build brand value, increase conversion rates, and grow revenue. Genome combines the best of the technology, data, analytics and media from Yahoo! and interclick; from Yahoo! — premium media and unmatched user data with proven targeting capabilities— and interclick — unified technology stack, third-party data partnerships and expertise in analytics and audiences. (more…)
Taking a sample from just one part of a tumour may not give a full picture of its‘genetic landscape’, according to a study published in the New England Journal of Medicine.
The findings could help explain why attempts at using single biopsies to identify biomarkers to which personalised cancer treatments can be targeted have not been more successful. (more…)
Researchers led by Matt Sullivan at the UA are among the first to dive into the world of viruses drifting through the world’s oceans.
Surrounded by the deep blue of the Pacific Ocean stretching from horizon to horizon, a lonely dot is glinting in the sun. It is the aluminum hull of a sailboat, a 118-foot schooner with white sails billowing from two masts.
On the deck, crewmembers and scientists are milling about. Commands are flying back and forth, and soon a strange contraption consisting of tubes clustered around an array of sensors dangling from a crane is lowered into the water, until it disappears in the clear blue depths. (more…)
An international team of researchers has discovered 13 new regions of the genome associated with the timing of menopause.
These genes shed light on the biological pathways involved in reproductive lifespan and will provide insights into conditions connected to menopause, such as breast cancer and heart disease.
Menopause is a major hormonal change that affects most women when they are in their early 50s. The timing of menopause can have a huge impact on fertility, as well as influencing the risk of a range of common diseases such as breast cancer. It has been known for some time that genetic factors influenced the onset of menopause, however until recently very few genes had been identified.
In the new study, published in the journal Nature Genetics on 22 January 2012, Dr Anna Murray, University of Exeter, Peninsula College of Medicine and Dentistry (PCMD) Dr John Perry, PCMD and WTCHG, University of Oxford, and dozens of international collaborators, examined the genomes of over 50,000 women. They identified 13 novel gene regions associated with menopause onset, and confirmed four previously identified. Most of the 17 regions include genes related to DNA damage/repair or the immune system, whilst others are linked to hormonal regulation. (more…)
*Anatomically modern humans interbred with more archaic hominin forms even before they migrated out of Africa, a UA-led team of researchers has found.*
It is now widely accepted that anatomically modern humans of the species Homo sapiens originated in Africa and eventually spread throughout the world. Ancient DNA recovered from fossil Neanderthal bones suggests they interbred with more archaic hominin forms once they had left their evolutionary cradle for the cooler climates of Eurasia, but whether they exchanged genetic material with other, now extinct archaic hominin varieties in Africa remained unclear.
