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New Insights into How Genetic Differences among Individuals Influence Breast Cancer Risk from Low-Dose Radiation

By Guest PostOctober 17, 2012Health, Scienceandy wyrobek, antoine snijders, berkeley lab, breast cancer, cancer risk, cellular, cellular proliferation, chemical therapy, ct scan, department, dna repair, energy, gene, genetic makeup, gland cancer, immune response, ionizing radiation, joe gray, low dose, mammary tissue, mechanism, mice, non radiation, radiotherapy, resistance, risk, scientist, strain, survival outcome, therapy, tissue mechanism, tissue stress, woman

Berkeley Lab research could lead to new ways to ID women who have higher risk of breast cancer from low-dose radiation

Scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified tissue mechanisms that may influence a woman’s susceptibility or resistance to breast cancer after exposure to low-dose ionizing radiation, such as the levels used in full-body CT scans and radiotherapy.

The research could lead to new ways to identify women who have higher or lower risks of breast cancer from low-dose radiation. Such a predictive tool could help guide the treatment of cancer patients who may be better served by non-radiation therapies. (more…)

Protein Linked to Therapy Resistance in Breast Cancer

By Guest PostSeptember 17, 2012Healthbreast cancer, breast cancer patients, future therapies, invasion of tumors, resistant to treatment, therapy resistance

Berkeley Lab Researchers Identify Possible New Oncogene and Future Therapy Target

A gene that may possibly belong to an entire new family of oncogenes has been linked by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) with breast cancer resistance to a well-regarded and widely used cancer therapy. (more…)

Study: Heart Damage after Chemo Linked to Stress in Cardiac Cells

By Guest PostMay 22, 2012Healthblocking, breast cancer, cancer cell, cardiac damage, cardiomyocytes, cellular level, chemotherapy, doxorubicin, drug, gene, govindasamy ilangovan, heart, heart muscle cells, heat shock factor 1, hsf 1, karthikeyan krishnamurthy, kaushik vedam, mdr1, multidrug resistance 1, nf kb, ohio state university, protein, ragu kanagasabai

COLUMBUS, Ohio – Blocking a protein in the heart that is produced under stressful conditions could be a strategy to prevent cardiac damage that results from chemotherapy, a new study suggests.

Previous research has suggested that up to a quarter of patients who receive the common chemotherapy drug doxorubicin are at risk of developing heart failure later in life. Exactly how that heart damage is done remains unclear.

In this study, scientists identified a protein called heat shock factor-1 (HSF-1) as a likely source of chemotherapy-related heart damage in mice and cell cultures. Heat shock factor-1 is known to be induced by stress – in this case, the chemotherapy treatment itself. (more…)

New Findings in Breast Cancer

By Guest PostApril 20, 2012Healthbreast cancer, breast cancer research, invasive tumors, treatment design, tumorigenic cells, tumorigenicity

Results from Berkeley Lab and University of Copenhagen Collaboration Contradict Current Views on Cancer Stem Cells

New findings in breast cancer research by an international team of scientists contradict the prevailing belief that only basal-like cells with stem cell qualities can form invasive tumors. Research led by Ole William Petersen at the University of Copenhagen (CU) and Mina Bissell of the Lawrence Berkeley National Laboratory (Berkeley Lab) and has shown that luminal-like cells with no detectable stem cell qualities can generate larger tumors than their basal-like counterparts. This may hold important implications for the diagnosis and the treatment of breast cancer as well as future personalized cancer medicine. (more…)

Stress About Wife’s Breast Cancer Can Harm A Man’s Health

By Guest PostApril 18, 2012Healthbreast cancer, cancer diagnosis, caroline dorfman, coughing, disease, gastrointestinal problems, hae chung yang, headaches, Health, immune dysregulation, kristen carpenter, laura simonelli, men, nausea, negative effect, ohio state, ohio state university, physical symptom, sharla wells di gregorio, stress assessment, stress symptom, symptom, treatment, weaker immune, william carson, wive

COLUMBUS, Ohio – Caring for a wife with breast cancer can have a measurable negative effect on men’s health, even years after the cancer diagnosis and completion of treatment, according to recent research.

Men who reported the highest levels of stress in relation to their wives’ cancer were at the highest risk for physical symptoms and weaker immune responses, the study showed. (more…)

‘Bed-of-Nails’ Breast Implant Deters Cancer Cells

By Guest PostMarch 26, 2012Healthbed of nails, blood vessel, breast cancer, brown university, cancer tumor, cell, cell function, chemical analysis, electron spectroscopy, lijuan zhang, malignant, michael platek, nanoscale, Nanotechnology, plga, protein, regrowth, thomas webster, tumor, united states, university of rhode island, vegf

Researchers at Brown University have created an implant that appears to deter breast cancer cell regrowth. Made from a common federally approved polymer, the implant is the first to be modified at the nanoscale in a way that causes a reduction in the blood-vessel architecture that breast cancer tumors depend upon, while also attracting healthy breast cells. Results are published in Nanotechnology.

PROVIDENCE, R.I. [Brown University] — One in eight women in the United States will develop breast cancer. Of those, many will undergo surgery to remove the tumor and will require some kind of breast reconstruction afterward, often involving implants. Cancer is an elusive target, though, and malignant cells return for as many as one-fifth of women originally diagnosed, according to the American Cancer Society. (more…)

Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

By Guest PostFebruary 19, 2012Healthbreast cancer, cancer cell, chemotherapy, dna damage, frank pajonk, ibcsc, induced pluripotent stem cells, ips, kim irwin, oncologist, radiation therapy, radiation treatment, regenerative medicine, stem cell, tumor, tumor recurrence

Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)

Berkeley Lab Researchers Discover a Rotational Motion of Cells that Plays a Critical Role in Their Normal Development

By Guest PostJanuary 29, 2012Science3d gel, acini, actomyosin, alexandre bruni cardoso, berkeley lab, breast cancer, breast feeding, camo, cell biology, cellular motion, coherent angular motion, component, counterclockwise, cytoskeleton, ecm, embryogenesis, evolutionary phenomena, extracellular matrix, function, hidetoshi mori, human epithelial cell, kandice tanner, laminin, mammary cell, mammary gland, microenvironment, mina bissell, multicellular organism, phenotypic reversion, protein, rana mroue, rotation, spherical structure, tissue polarity

In a study that holds major implications for breast cancer research as well as basic cell biology, scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered a rotational motion that plays a critical role in the ability of breast cells to form the spherical structures in the mammary gland known as acini. This rotation, which the researchers call “CAMo,” for coherent angular motion, is necessary for the cells to form spheres. Without CAMo, the cells do not form spheres, which can lead to random motion, loss of structure and malignancy.

”What is most exciting to me about this stunning discovery is that it may finally give us a handle by which to discover the physical laws of cellular motion as they apply to biology,” says Mina Bissell, a leading authority on breast cancer and Distinguished Scientist with Berkeley Lab’s Life Sciences Division. (more…)

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