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‘Bed-of-Nails’ Breast Implant Deters Cancer Cells

By Guest PostMarch 26, 2012Healthbed of nails, blood vessel, breast cancer, brown university, cancer tumor, cell, cell function, chemical analysis, electron spectroscopy, lijuan zhang, malignant, michael platek, nanoscale, Nanotechnology, plga, protein, regrowth, thomas webster, tumor, united states, university of rhode island, vegf

Researchers at Brown University have created an implant that appears to deter breast cancer cell regrowth. Made from a common federally approved polymer, the implant is the first to be modified at the nanoscale in a way that causes a reduction in the blood-vessel architecture that breast cancer tumors depend upon, while also attracting healthy breast cells. Results are published in Nanotechnology.

PROVIDENCE, R.I. [Brown University] — One in eight women in the United States will develop breast cancer. Of those, many will undergo surgery to remove the tumor and will require some kind of breast reconstruction afterward, often involving implants. Cancer is an elusive target, though, and malignant cells return for as many as one-fifth of women originally diagnosed, according to the American Cancer Society. (more…)

Surgical Treatment for Epilepsy Should Not be Viewed As a Last Resort, Study Shows

By Guest PostMarch 13, 2012Healthamerican, anti epileptic drug, brain surgery, breast cancer, cognitive problems, disability, epilepsy, harry vinters, itzhak fried, jerome engel, john stern, karl kieburtz, lung cancer, mesial temporal lobe epilepsy, sandra dewar, seizure, treatment

*Most patients wait until it’s too late to prevent serious disability*

While the thought of any type of surgery can be disconcerting, the thought of brain surgery can be downright frightening. But for people with a particular form of epilepsy, surgical intervention can literally be life-restoring.

Yet among people who suffer from what’s known as medically intractable epilepsy, in which seizures are resistant to drugs, only a small fraction will seek surgery, seeing it only as a last resort. As a result, they continue to suffer seizures year after year. They can’t drive, they can’t work and they lose cognitive function as the years pass. Premature death is not uncommon. (more…)

Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

By Guest PostFebruary 19, 2012Healthbreast cancer, cancer cell, chemotherapy, dna damage, frank pajonk, ibcsc, induced pluripotent stem cells, ips, kim irwin, oncologist, radiation therapy, radiation treatment, regenerative medicine, stem cell, tumor, tumor recurrence

Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)

Berkeley Lab Researchers Discover a Rotational Motion of Cells that Plays a Critical Role in Their Normal Development

By Guest PostJanuary 29, 2012Science3d gel, acini, actomyosin, alexandre bruni cardoso, berkeley lab, breast cancer, breast feeding, camo, cell biology, cellular motion, coherent angular motion, component, counterclockwise, cytoskeleton, ecm, embryogenesis, evolutionary phenomena, extracellular matrix, function, hidetoshi mori, human epithelial cell, kandice tanner, laminin, mammary cell, mammary gland, microenvironment, mina bissell, multicellular organism, phenotypic reversion, protein, rana mroue, rotation, spherical structure, tissue polarity

In a study that holds major implications for breast cancer research as well as basic cell biology, scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered a rotational motion that plays a critical role in the ability of breast cells to form the spherical structures in the mammary gland known as acini. This rotation, which the researchers call “CAMo,” for coherent angular motion, is necessary for the cells to form spheres. Without CAMo, the cells do not form spheres, which can lead to random motion, loss of structure and malignancy.

”What is most exciting to me about this stunning discovery is that it may finally give us a handle by which to discover the physical laws of cellular motion as they apply to biology,” says Mina Bissell, a leading authority on breast cancer and Distinguished Scientist with Berkeley Lab’s Life Sciences Division. (more…)

Young Breast Cancer Survivors Face Serious Quality-of-Life Challenges

By Guest PostJanuary 26, 2012Healthanxiety level, breast cancer, breast cancer patients, breast cancer survivor, cancer, cancer prevention, cancer progression, cytotoxic therapy, infertility, kim irwin, los angeles, patricia ganz, premature menopause, psychological distress, psychosocial needs, quality of life, stress and anxiety, susan g komen, women, younger

*Researchers seek ways to address long-term effects of treatment*

Quality of life in younger patients treated for breast cancer is seriously compromised, and these women face more physical and mental health issues than women their age who haven’t had cancer and women over 50 who have, according to a study by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

The study, published Jan. 20 in the peer-reviewed Journal of the National Cancer Institute, found that younger breast cancer survivors suffer from a slew of problems, including severe psychological distress, infertility, premature menopause, a decrease in physical activity and weight gain. (more…)

Gene Research Sheds Light on Timing of Menopause

By Guest PostJanuary 23, 2012Healthanna murray, breast cancer, cardiovascular disease, damage, early menopause, genes, genetic studies, genome, heart disease, hormonal change, hormonal regulation, immune system, joanne murabito, john perry, kathryn lunetta, menopause, menopause onset, oestrogen exposure, post menopausal women, pre menopausal, repair, reproductive disorders, reproductive lifespan, timing of menopause, university of exeter, university of oxford

An international team of researchers has discovered 13 new regions of the genome associated with the timing of menopause.

These genes shed light on the biological pathways involved in reproductive lifespan and will provide insights into conditions connected to menopause, such as breast cancer and heart disease.

Menopause is a major hormonal change that affects most women when they are in their early 50s. The timing of menopause can have a huge impact on fertility, as well as influencing the risk of a range of common diseases such as breast cancer. It has been known for some time that genetic factors influenced the onset of menopause, however until recently very few genes had been identified.

In the new study, published in the journal Nature Genetics on 22 January 2012, Dr Anna Murray, University of Exeter, Peninsula College of Medicine and Dentistry (PCMD) Dr John Perry, PCMD and WTCHG, University of Oxford, and dozens of international collaborators, examined the genomes of over 50,000 women. They identified 13 novel gene regions associated with menopause onset, and confirmed four previously identified. Most of the 17 regions include genes related to DNA damage/repair or the immune system, whilst others are linked to hormonal regulation. (more…)

Breast Cancer Survivors Benefit From Practicing Mindfulness-Based Stress Reduction, MU Researchers Find

By Guest PostDecember 31, 2011Healthamerican cancer society, breast cancer, health challenges, jane armer, lifestyles and belief, mbsr, meditation, meditation technique, mindfulness, mindfulness based stress reduction, physical awareness, positive effects, post diagnosis, survivors, university of missouri, women, yaowarat matchim, yoga

*Survivors’ psychological and physiological health improved after training*

COLUMBIA, Mo. – Women recently diagnosed with breast cancer have higher survival rates than those diagnosed in previous decades, according to the American Cancer Society. However, survivors continue to face health challenges after their treatments end. Previous research reports as many as 50 percent of breast cancer survivors are depressed. Now, University of Missouri researchers in the Sinclair School of Nursing say a meditation technique can help breast cancer survivors improve their emotional and physical well-being. (more…)

Diabetes Drug Shows Promise in Reducing Risk of Cancer

By Guest PostNovember 26, 2011Healthbreast cancer, breast tumor, diabetes associated cancers, diabetes drug, risk of cancer

EAST LANSING, Mich. — An inexpensive drug that treats Type-2 diabetes has been shown to prevent a number of natural and man-made chemicals from stimulating the growth of breast cancer cells, according to a newly published study by a Michigan State University researcher. (more…)

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