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Latest JBEI Startup to Speed Up Biotech Industry

By Guest PostOctober 3, 2012Scienceautocad, berkeley lab, biofuels, biology, chemicals, cutting edge, design, DNA, dna manipulation, eduardo abeliuk, electrical engineering, expressing, inertia, iso27001, j5 software, jbei, majed abolfazli, medicine, metabolic pathway, mike fero, modern cloning, molecular biology, nathan hillson, organism, pharmchem, protocol, qb3, san francisco, Science, sequencing, splicing, stanford university, teselagen

TeselaGen’s DNA construction technology makes genetic engineering cheaper and faster.

Sequencing, splicing and expressing DNA may seem to be the quintessence of cutting-edge science—indeed DNA manipulation has revolutionized fields such as biofuels, chemicals and medicine. But in fact, the actual process can still be tedious and labor-intensive, something Lawrence Berkeley National Laboratory (Berkeley Lab) scientist Nathan Hillson learned the hard way.

After struggling for two days to design a protocol to put together a genetic circuit with 10 pieces of DNA—using a spreadsheet as his primary tool—he was dismayed to discover that an outside company could have done the whole thing, including parts and labor, for lower cost than him ordering the oligonucleotides himself. “I learned two things: one, I never wanted to go through that process again, and two, it’s extremely important to do the cost-effectiveness calculation,” said Hillson, a biochemist who also directs the synthetic biology program at the Berkeley Lab-led Joint BioEnergy Institute (JBEI). “So that was the genesis of the j5 software. This is the perfect thing to teach a computer to do.” (more…)

3-D Mapping of Isaac Water Levels

By Guest PostSeptember 1, 2012Environment, Science360 degree, 3d mapping, 3d model, alabama, athena clark, bounce back, data points, flood hazard, flood inundation, geological survey, gulf coast, hurricane isaac, isaac, louisiana, map, marcia mcnutt, Mississippi, objects, point clouds, Science, t lidar, terrestrial lidar, three dimensions, tls, toby minear, topographic data, urban flooding, US, view, water level

A new technology is being deployed by U.S. Geological Survey scientists this weekend to map urban flooding caused by Hurricane Isaac. Called “terrestrial lidar,” or “T-lidar”, this new capability will enable scientists to collect highly detailed information in select population areas in Louisiana, Mississippi, and Alabama where the hurricane had the greatest impact.

The portable instrument allows scientists to quickly generate 3-D maps of buildings, dams, levees and other structures, and can show areas of storm damage as well. In a four-to-five minute scan, the instrument collects millions of topographic data points in a full 360-degree view to quickly produce highly accurate topographic information and can map areas up to two-thirds of a mile away. (more…)

Doing Science to Teach Science

By Guest PostAugust 22, 2012Education, Scienceallen boltz, ashok gadgil, autumn chapman, berkeley darfur stove, berkeley lab, brito guedes, california, cookstove, dna repair, high school, iisme, jill fuss, monique, nigel quinn, particulate, pe teacher, polymerase chain reactions, san joaquin basin, Science, skin deformities, sophomore chemistry, teacher, thermodynamic

A summer of research at Berkeley Lab gives high school teachers a jump start on science.

High school science teachers face a perennial problem: how to make science real and exciting to their students. But for Berkeley High School teacher Allen Boltz, who spent eight weeks at Lawrence Berkeley National Laboratory working in a research lab, he will be returning to his classroom this fall a near rock star.

“This experience gives a lot of credibility to the teaching profession,” he said. “To my students, me doing research here would be the equivalent to their PE teacher being a professional athlete.” (more…)

Entropy Can Lead to Order, Paving The Route to Nanostructures

By Guest PostJuly 28, 2012Scienceaerodynamics, atoms, computer simulation, crystal structure, disorder, drifting particle, entropy, michael engel, nanoparticle, pablo damasceno, particle, Science, shape, sharon glotzer, university of michigan

ANN ARBOR, Mich.— Researchers trying to herd tiny particles into useful ordered formations have found an unlikely ally: entropy, a tendency generally described as “disorder.”

Computer simulations by University of Michigan scientists and engineers show that the property can nudge particles to form organized structures. By analyzing the shapes of the particles beforehand, they can even predict what kinds of structures will form.

The findings, published in this week’s edition of Science, help lay the ground rules for making designer materials with wild capabilities such as shape-shifting skins to camouflage a vehicle or optimize its aerodynamics. (more…)

Global Science: U.S. is Still in The Game

By Guest PostJune 19, 2012Sciencealexandra achen killewald, america today, american economy, american science, decline, globalization, harvard university, mathematics, new york times, newsweek, popular media, relative scale, Science, scientific achievement, united states, university of michigan, US, yu xie

ANN ARBOR, Mich.— Globalization is a benefit to U.S. scientific achievement, not a threat. That’s the conclusion of a new book that weighs the evidence from a number of recent surveys to answer its title question: “Is American Science in Decline?”

American science is in good health, according to the book’s authors, sociologists Yu Xie of the University of Michigan and Alexandra Achen Killewald of Harvard University.

Although there are areas of concern, they maintain that traditional American values will help the nation maintain its strength in science for the foreseeable future, and that globalization will promote efficiency in science through knowledge sharing. (more…)

Powerful New Approach to Attack Flu Virus

By Guest PostMay 29, 2012Scienceadaptable virus, avian flu, biopharmaceutical industry, dna deep sequencing, flu epidemics, flu virus, H1N1, H5N1, Israel, kurt stepnitz, la jolla, michigan state university, mutations, nature biotechnology, new approach, pandemic influenza viruses, protein, rehovot, san diego, Science, scripps research institute, smallpox, subtypes, swine flu, therapeutic proteins, tim whitehead, university of washington, weizmann institute

EAST LANSING, Mich. — An international research team has manufactured a new protein that can combat deadly flu epidemics.

The paper, featured on the cover of the current issue of Nature Biotechnology, demonstrates ways to use manufactured genes as antivirals, which disable key functions of the flu virus, said Tim Whitehead, assistant professor of chemical engineering and materials science at Michigan State University.

“Our most potent design has proven effective on the vulnerable sites on many pandemic influenza viruses, including several H1N1 (Spanish flu, Swine flu) and H5N1 (Avian flu) subtypes,” said Whitehead, the paper’s co-lead author. “These new therapeutics are urgently needed, so we were especially pleased to see that it neutralizes H1N1 viruses with potency.” (more…)

My Fair Physicist? Feminine Math, Science Role Models Do Not Motivate Girls

By Guest PostApril 26, 2012General, Sciencedenise sekaquaptewa, diana betz, engineering, excel, feminine qualities, field, jared wadley, mathematic, role model, Science, stem, stereotype, Technology, unfeminine, university of michigan, women

ANN ARBOR, Mich.— Women who excel in male-dominated science, technology, engineering and mathematic fields are often unjustly stereotyped as unfeminine.

However, if women are perceived as having feminine qualities, their success may actually decrease interest in these fields (usually referred to as “STEM”), particularly among young girls, according to a new University of Michigan study. (more…)

U.S. Students Need New Way of Learning Science

By Guest PostApril 7, 2012Educationamerican students, atoms, cells, conservation of mass and energy, digital organisms, energy, forces, genomics, k 12 school, michigan state university, next generation, prom se, radiation, research project, Science, science standard, scientific fact, simon billinge, stephen pruitt, student assessment, synthetic biology, systems change, united states, variation, william schmidt

EAST LANSING, Mich. — American students need a dramatically new approach to improve how they learn science, says a noted group of scientists and educators led by Michigan State University professor William Schmidt.

After six years of work, the group has proposed a solution. The 8+1 Science concept calls for a radical overhaul in K-12 schools that moves away from memorizing scientific facts and focuses on helping students understand eight fundamental science concepts. The “plus one” is the importance of inquiry, the practice of asking why things happen around us – and a fundamental part of science. (more…)

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