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Berkeley Lab Scientists Create First 3-D Model of a Protein Critical to Embryo Development

By Guest PostSeptember 21, 2012Science3d model, aebp2, alessio maiolica, angstroms, arm1, arm2, berkeley lab, birth defect, cancer, chromatin environment, claudio ciferri, complex, complex 2, crystal structure, DNA, electron microscopy, eva nogales, franz herzog, function, gabriel lander, human, mass spectrometry, mechanism, model, molecular architecture, nucleosome, polycomb, prc2, progression, protein, protein biochemistry, repressive, ruedi aebersold, therapeutic drug

The first detailed and complete picture of a protein complex that is tied to human birth defects as well as the progression of many forms of cancer has been obtained by an international team of researchers led by scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). Knowing the architecture of this protein, PRC2, for Polycomb Repressive Complex 2, should be a boon to its future use in the development of new and improved therapeutic drugs.

“We present a complete molecular organization of human PRC2 that offers an invaluable structural context for understanding all of the previous biochemical and functional data that has been collected on this complex,” says Berkeley Lab biophysicist Eva Nogales, an electron microscopy expert who led this research. “Our model should also be an invaluable tool for the design of new experiments aimed at asking detailed questions about the mechanisms that enable PRC2 to function and how those mechanisms might be exploited.” (more…)

3-D Mapping of Isaac Water Levels

A new technology is being deployed by U.S. Geological Survey scientists this weekend to map urban flooding caused by Hurricane Isaac. Called “terrestrial lidar,” or “T-lidar”, this new capability will enable scientists to collect highly detailed information in select population areas in Louisiana, Mississippi, and Alabama where the hurricane had the greatest impact.

The portable instrument allows scientists to quickly generate 3-D maps of buildings, dams, levees and other structures, and can show areas of storm damage as well. In a four-to-five minute scan, the instrument collects millions of topographic data points in a full 360-degree view to quickly produce highly accurate topographic information and can map areas up to two-thirds of a mile away. (more…)

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Berkeley Lab Scientists Create First 3-D Model of a Protein Critical to Embryo Development

3-D Mapping of Isaac Water Levels