Using a specially designed facility, UCLA stem cell scientists have taken human skin cells, reprogrammed them into cells with the same unlimited property as embryonic stem cells, and then differentiated them into neurons while completely avoiding the use of animal-based reagents and feeder conditions throughout the process.
Generally, stem cells are grown using mouse “feeder” cells, which help the stem cells flourish and grow. But such animal-based products can lead to unwanted variations and contamination, and the cells must be thoroughly tested before they can be deemed safe for use in humans. (more…)
Beta oscillations are tightly linked to Parkinson’s disease and the ability to process sensory information, such as touch. Two neuroscientists have brought their collaboration to Brown University and won funding from the National Science Foundation to see if they can finally provide a definitive, if unorthodox, explanation for beta brainwaves.
Before she could seek to convince the world that her computer model of a key brain circuit explains a fundamental, 80-year-old mystery of neuroscience with potential relevance to Parkinson’s disease, Stephanie Jones sought to convince Christopher Moore. The new Brown neuroscience professors are now close collaborators, but when they first started talking about the beta oscillations of the cortex, Moore thought Jones was plain wrong, if not a bit nuts. (more…)
Obesity is growing at alarming rates worldwide, and the biggest culprit is overeating. In a study of brain circuits that control hunger and satiety, Yale School of Medicine researchers have found that molecular mechanisms controlling free radicals-molecules tied to aging and tissue damage-are at the heart of increased appetite in diet-induced obesity.
Published Aug. 28 in the advanced online issue of Nature Medicine, the study found that elevating free radical levels in the hypothalamus directly or indirectly suppresses appetite in obese mice by activating satiety-promoting melanocortin neurons. Free radicals, however, are also thought to drive the aging process. (more…)
Animal’s brains are only roughly aware of how high-up they are in space, meaning that in terms of altitude the brain’s ‘map’ of space is surprisingly flat, according to new research.
In a study published online in Nature Neuroscience, scientists studied cells in or near a part of the brain called the hippocampus, which forms the brain’s map of space, to see whether they were activated when rats climbed upwards. (more…)
Using a unique and relatively simple cell-based fluorescent assay they developed, scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC), Berkeley have identified a means by which fluoxetine, the active ingredient in Prozac, suppresses the activity of the TREK1 potassium channel. TREK1 activity has been implicated in mood regulation and could be an important target for fluoxetine and other antidepressant drugs. (more…)
Migraines are a chronic brain condition characterized by attacks of a throbbing headache, of medium or strong intensity, possibly associated with nausea, vomiting, photophobia and intolerance to sounds (phonophobia). In about a third of cases, seizures are accompanied by neurological symptoms, usually visual, known as auras. The disorder occurs in those who are genetically susceptible. The World Health Organization estimates that worldwide there are 324 million people who suffer from in this condition. (more…)
Mouse Stroke. An MRI of a mouse brain after stroke. The mouse section has been stained to show cell bodies. Image credit: University of California
A stroke wreaks havoc in the brain, destroying its cells and the connections between them. Depending on its severity and location, a stroke can impact someone’s life forever, affecting motor activity, speech, memories, and more.
The brain makes an attempt to rally by itself, sprouting a few new connections, called axons, that reconnect some areas of the brain. But the process is weak, and the older the brain, the poorer the repair. Still, understanding the cascade of molecular events that drive even this weak attempt could lead to developing drugs to boost and accelerate this healing process.
Now researchers at UCLA have achieved a promising first step. Reporting in the current online edition of the journal Nature Neuroscience, senior author Dr. S. Thomas Carmichael, a UCLA associate professor of neurology, and colleagues have, for the first time, identified in the mouse the molecular cascade that drives the process of reconnection or sprouting in the adult brain after stroke.(more…)
Until now it was believed that a person is unable to read the thoughts of fellow human beings. “Spying” on the dreams of another person appeared unrealistic. However, recent research by American scientists revealed that both these things are quite possible. Overly complex devices and paranormal abilities are not required to do so.
Recently, a respectable scientific journal Nature published an article that ten years ago would have been considered a fiction and would not have been publication at all. A group of American researchers led by Dr. Moran Cerf claims to have found a way to electronically records and decipher human dreams and thoughts. No complicated devices are required. The entire transcript can successfully go through an electroencephalograph – a device that for decades has been used by neuroscientists around the world. (more…)
